COVID & the BRAIN… a thread 🧵
SARS-CoV-2 infection in microglia and its sequelae: What do we know so far?
“SARS-CoV-2 may infect CNS, affecting microglia and brain cells. • Neuroinflammation from SARS-CoV-2 could lead to long COVID memory issues.”
SARS-CoV-2 may infect CNS, affecting microglia and brain cells.•Neuroinflammation from SARS-CoV-2 could lead to long COVID memory issues.
Cognition and Memory after Covid-19 in a Large Community Sample | NEJM
Cognition and Memory after Covid-19 in a Large Community Sample
Cognition and Memory after Covid-19 in a Large Community Sample
Mounting research shows that COVID-19 leaves its mark on the brain, including significant drops in IQ scores : r/news
“Mounting research shows that COVID-19 leaves its mark on the brain, including significant drops in IQ scores"
From COVID to Cognition | Kentucky researchers find COVID-19 could lead to Alzheimer's
“From COVID to Cognition | Kentucky researchers find COVID-19 could lead to Alzheimer's”
From COVID to Cognition | Kentucky researchers find COVID-19 could lead to Alzheimer's
Serotonin reduction in post-acute sequelae of viral infection
Long COVID is linked to reduced serotonin levels, which are driven by viral RNA-induced type I interferons (IFNs).
Peripheral serotonin deficiency impairs cognition by reducing vagal nerve signaling, affecting hippocampal responses and memory.
The buddy from college I talk about every now and again.
“The buddy from college I talk about every now and again.
He’s prolly 50 or so. He posted this a few days ago. He has already had a rough go of it, he has a daughter he is devoted to, and who loves him immensely.
I am as sad as I am angry. “
Worse, most people don’t even notice it has happened to themselves.
“Worse, most people don’t even notice it has happened to themselves.
But I can tell you we who continue to mask and have many fewer COVID infections can see the growing cognitive damage in more and more people around us.
Memory problems, like recall and word finding delays. Weakness and fatigue and motor control impairment. Growing executive function and emotional regulation deficits.
More and more friends disables and forced out of work or school by Long COVID symptoms.
It’s scary to witness the broad societal decline, and dispiriting to see so many governments and Public Health agencies persist in minimizing the growing problem.”
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COVID Linked to Lower IQ, Poor Memory and Other Negative Impacts on Brain Health
“COVID-19 poses a serious risk to brain health, even in mild cases, and the effects are now being revealed at the population level,"
COVID-19 poses a serious risk to brain health, even in mild cases, and the effects are now being revealed at the population level,"
A 43% increase since 2019.
A 43% increase cognitive disabilities since 2019.
“This is tragic and horrifying. And it’s going to get progressively worse as we’re all systematically reinfected.”
Whoopi Goldberg Commiserates With Fellow-Covid Sufferer Joe Biden: “Sometimes I Go For A Word And It’s Not There”
Whoopi Goldberg, who just had her 4th COVID infection, joked about her post infection brain damage on TV.
“I’m just getting over COVID – again – and I can barely remember anybody’s name. There are times when I go for a word and it’s not there.”
Emerging signs of Alzheimer‐like tau hyperphosphorylation and neuroinflammation in the brain post recovery from COVID‐19
Emerging signs of Alzheimer’s-like pathology in brains if people recovered from COVID-19, even though no direct SARS-CoV-2 invasion was detected
Study shows that COVID-19 causes cognitive decline among those without long COVID symptoms
“A new study in eClinicalMedicine has found that healthy volunteers infected with SARS-CoV-2 had measurably worse cognitive function for up to a year after infection when compared to uninfected controls. Significantly, infected controls did not report any symptoms related to these cognitive deficits, indicating that they were unaware of them.”
A new study in eClinicalMedicine has found that healthy volunteers infected with SARS-CoV-2 had measurably worse cognitive function for up to a year after infection when compared to uninfected controls. Significantly, infected controls did not report any symptoms related to these cognitive deficits, indicating that they were unaware of them. The net effect is that potentially billions of people worldwide with a his
Covid Brain
“But this week 2 new publications have substantially added to our understanding of the extent that Covid can impair cognitive function across the full gamut— from young, healthy individuals with mild infections to older, hospitalized patients with severe Covid.”
Long COVID is not the same for everyone: a hierarchical cluster analysis of Long COVID symptoms 9 and 12 months after SARS-CoV-2 test - BMC Infectious Diseases
“Our results suggest that Long COVID is not the same for everyone.”
Our results suggest that Long COVID is not the same for everyone.
Research Shows Severe COVID-19 Contributes to Long-Lasting Cognitive Impairment - InventUM
“We found persistent subjective and objective cognitive issues even two years after infection, including brain fog, word-finding problems, working memory deficits and reduced processing speed.” “Most Patients Have Never Fully Recovered”
“We found persistent subjective and objective cognitive issues even two years after infection, including brain fog, word-finding problems, working memory deficits and reduced processing speed.”
“Most Patients Have Never Fully Recovered”
One infection in ‘22, took Paxlovid. Still got TBI. Not recovered. Was ultra marathon runner, cyclist, executive. Fit, active. Everyone is at risk of poor outcome, even infants. Thanks for raising awareness.
“One infection in ‘22, took Paxlovid. Still got TBI. Not recovered. Was ultra marathon runner, cyclist, executive. Fit, active. Everyone is at risk of poor outcome, even infants.”
BLOOMBERG TWEETING OUT COVID has all sorts of cognitive issues and of a coming SURGE OF DEMENTIA?
Does Covid Lead to Dementia? Here's What the Virus May Have Done to Y…
Non paywall version of catalogued Bloomberg article
Scientists are worried that persisting cognitive issues may signal a coming surge of dementia and other mental conditions
What We Know About Covid’s Impact on Your Brain
“Scientists are worried that persisting cognitive issues may signal a coming surge of dementia and other mental conditions”
Parallel electrophysiological abnormalities due to COVID‐19 infection and to Alzheimer's disease and related dementia
“Resting-state EEG abnormalities include EEG slowing (reduced alpha rhythm; increased slow waves) and epileptiform activity. An expert panel conducted a systematic review to present compelling evidence that cognitive deficits due to COVID-19 and to Alzheimer's disease and related dementia (ADRD) are driven by overlapping pathologies and neurophysiological abnormalities. EEG abnormalities seen in COVID-19 patients resemble those observed in early stages of neurodegenerative diseases, particularly ADRD”
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Loss of IQ from Covid
‘Brain fog’ from long Covid has measurable impact, study suggests
“Researchers found that deficits equivalent to six IQ points were detectable a year or more after infection”
A groundbreaking study aims to determine if long COVID-19 could lead to another type of dementia
“‘…there is evidence of fragments or an inflammatory kind of a massive inflammatory response that occurs triggered by COVID. And those inflammatory markers we tend to notice in the brain.’
And that could cause something called COVID-19 Cognitive Impairment.
‘And we are going to compare people with COVID cognitive impairment. To be clear on this, I think that COVID can cause cognitive impairment and maybe even dementia…’”
Prevalence and co-occurrence of cognitive impairment in children and young people up to 12-months post infection with SARS-CoV-2 (Omicron variant) - PubMed
Prevalence and co-occurrence of cognitive impairment in children and young people up to 12-months post infection with SARS-CoV-2
Study uncovers the basis of COVID-19-related brain fog | University of Minnesota
EXTREME and incomplete oversimplification of the many complex neurological issues caused by SarsCov2, but important facet of the vaguely defined “brain fog” of Long Covid and post-acute Covid lingering symptoms.
“Neurological symptoms have been widely observed in COVID-19 patients, with many survivors exhibiting persistent neurological and cognitive impairment. New research from the University of Minnesota found that COVID-19 triggers inflammation in the brain, which is linked to many COVID-related symptoms such as fatigue and ‘brain fog.’”
Dutch Survey Data Shows Significant Increase In Memory And Concentration Problems Among Adults Since Start Of Covid-19 Pandemic
"Dutch Survey Data Shows Significant Increase In Memory And Concentration Problems Among Adults Since Start Of Covid-19 Pandemic"
COVID-19 could put us at a greater risk of neurodegenerative diseases and stroke
"Analysis of nearly one million Danish health records has found patients who tested positive for COVID-19 were subsequently more likely to be diagnosed with Alzheimer’s disease, Parkinson’s disease and stroke."
Cerebral hypoperfusion in post-COVID-19 cognitively impaired subjects revealed by arterial spin labeling MRI
Study examining patients at a long COVID neurology clinic showing deficits in executive, attention, language and memory functions. MRIs showed reduced blood flow to frontal, parietal and temporal regions of the brain compared to age & sex matched controls
Long Covid changes the human brain. We may finally know how
"Long Covid changes the human brain. We may finally know how
Lost connections between nerve cells in the brain may explain cognitive symptoms such as brain fog and memory lapses."