SARS-CoV-2 Orf6 Triggers MTCH1-Dependent Mitochondrial Dysfunction and Necroptosis in Human Neurons | Research Square
A new preprint study shows that the SARS-CoV-2 protein ORF6 directly kills human neurons. Not by accident, but through necroptosis - a kind of cell death where neurons burst and fuel inflammation. This may underlie the long-term brain symptoms of Long COVID.