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Thread by @IntegralAnswers on Thread Reader App
Thread by @IntegralAnswers on Thread Reader App

“Thread: A molecular clue to Long COVID “brain fog”

1/ New study from Yokohama City Univ used PET imaging of AMPA receptors. Long COVID patients showed elevated AMPAR levels, linked to both cognitive impairment and inflammation. A molecular biomarker emerges.”

Thread: A molecular clue to Long COVID “brain fog” 1/ New study from Yokohama City Univ used PET imaging of AMPA receptors. Long COVID patients showed elevated AMPAR levels, linked to both cognitive impairment and inflammation. A molecular biomarker emerges.
#brain fog#Cognitive Impairment#Long Covid#Post-Acute Conditions#molecular#molecular changes
·threadreaderapp.com·
Thread by @IntegralAnswers on Thread Reader App
Systemic increase of AMPA receptors associated with cognitive impairment of long COVID | Brain Communications | Oxford Academic
Systemic increase of AMPA receptors associated with cognitive impairment of long COVID | Brain Communications | Oxford Academic
“Long COVID primarily presents with persistent cognitive impairment (Cog-LC), imposing a substantial and lasting global burden. Even after the pandemic, there remains a critical global need for diagnostic and therapeutic strategies targeting Cog-LC.”
Long COVID primarily presents with persistent cognitive impairment (Cog-LC), imposing a substantial and lasting global burden. Even after the pandemic, there remains a critical global need for diagnostic and therapeutic strategies targeting Cog-LC.
#Cognitive Impairment#Long Covid#brain#brain fog#Post-Acute Conditions
·academic.oup.com·
Systemic increase of AMPA receptors associated with cognitive impairment of long COVID | Brain Communications | Oxford Academic
New study reveals molecular basis of Long COVID brain fog
New study reveals molecular basis of Long COVID brain fog
“the researchers found a notable and widespread increase in the density of AMPARs across the brains of patients. This elevated receptor density was directly correlated with the severity of their cognitive impairment, suggesting a clear link between these molecular changes and the symptoms. Additionally, the concentrations of various inflammatory markers were also correlated with AMPAR levels, indicating a possible interaction between inflammation and receptor expression.”
#Long Covid#brain fog#Cognitive Impairment#cognition#brain#AMPARS#molecular#molecular changes#inflammation#Post-Acute Conditions
·news-medical.net·
New study reveals molecular basis of Long COVID brain fog
Human challenge study reveals lasting cognitive decline after mild COVID-19
Human challenge study reveals lasting cognitive decline after mild COVID-19

“significant memory and executive function decline lasting up to a year, despite no reported subjective symptoms, prompting new questions about the virus’s long-term cognitive effects.”

Unvaccinated volunteers who contracted COVID-19 in a human challenge study showed
#cognitive decline#memory#long covid#cognition#Cognitive Impairment#Brain Fog#Long Covid#Post-Acute Conditions#Brain#neurological
·news-medical.net·
Human challenge study reveals lasting cognitive decline after mild COVID-19
Lacking focus, tired always? Could be brain fog
Lacking focus, tired always? Could be brain fog

“Brain fog may gradually evolve into a slight memory problem, difficulty finding the right word for things, objects, situations and then registering new information.”

A widely held notion is that SARS2 activates our immune systems, causing an inflammatory response in the brain.

#Memory#cognition#Long Covid#brain fog#Cognitive Decline#Post-Acute Conditions#Cognitive Impairment#cognitive decline#Neuroinflammation
·newindianexpress.com·
Lacking focus, tired always? Could be brain fog
Cognitive Slowing, Dysfunction in Verbal Working Memory, Divided Attention and Response Inhibition in Post COVID-19 Condition in Young Adults
Cognitive Slowing, Dysfunction in Verbal Working Memory, Divided Attention and Response Inhibition in Post COVID-19 Condition in Young Adults

The present study revealed that in YOUNG adults, university students, without other comorbidities, there can be significant long-lasting cognitive impairments TWO YEARS after COVID-19 infection."

➡️"Specifically, verbal working memory was significantly impaired, and a lower performance was detected in divided attention and response inhibition.”

#Long Covid#cognition#Covid-19 Cognitive Impairment#executive function#young people#Memory#Brain Fog#Cognitive Impairment#Cognition
·mdpi.com·
Cognitive Slowing, Dysfunction in Verbal Working Memory, Divided Attention and Response Inhibition in Post COVID-19 Condition in Young Adults
Scientists find two brain biomarkers in long COVID sufferers that may be causing cognitive issues
Scientists find two brain biomarkers in long COVID sufferers that may be causing cognitive issues
“A new study that is the first to compare inflammation and brain stress responses in long COVID-19 patients with individuals who have fully recovered shows that those with continued brain fog and other cognitive issues have a lower ability to adapt to stress and higher levels of inflammation in their brains.”
A new study that is the first to compare inflammation and brain stress responses in long COVID-19 patients with individuals who have fully recovered shows that those with continued brain fog and other cognitive issues have a lower ability to adapt to stress and higher levels of inflammation in their brains.
#Neuroinflammation#brain inflammation#brain fog#cognition#Brain#Cognition#Cognitive Impairment#Long Covid
·medicalxpress.com·
Scientists find two brain biomarkers in long COVID sufferers that may be causing cognitive issues
Clinic evaluation of cognitive impairment in post-COVID syndrome: Performance on legacy pen-and-paper and new digital cognitive tests
Clinic evaluation of cognitive impairment in post-COVID syndrome: Performance on legacy pen-and-paper and new digital cognitive tests

“Post-Covid cognitive impairment affects daily function and quality of life. • ACE-III fails to detect cognitive impairment in most post-Covid patients. • 89% of patients have impaired attention, executive function, processing speed on novel tests. • New tests are needed for post-Covid cognitive assessment in clinical practice.”

Post-Covid cognitive impairment affects daily function and quality of life.•ACE-III fails to detect cognitive impairment in most post-Covid patients.•89% of patients have impaired attention, executive function, processing speed on novel tests.•New tests are needed for post-Covid cognitive assessment in clinical practice.
#Cognitive Impairment#Brain Fog#Long Covid#cognition#Cognitive decline#Cognitive Fatigue#Covid-19 Cognitive Impairment#post-covid testing#Post Covid Testing
·sciencedirect.com·
Clinic evaluation of cognitive impairment in post-COVID syndrome: Performance on legacy pen-and-paper and new digital cognitive tests