Investigating the Neuroimmune, Cerebrovascular, and Cognitive Disturbances Associated with SARS‑CoV‑2 Infection: A Systematic Review of Post‑Acute Outcomes | Research Square
“A systematic review of 73,435 COVID-19 survivors found that 42% had persistent neuroinflammation, 22% had cerebrovascular injury, and 58% had cognitive impairment.”
Association between COVID-19 infection and new-onset dementia in older adults: a systematic review and meta-analysis - BMC Geriatrics
“11 studies (involving 939,824 post-COVID-19 survivors and 6,765,117 controls) were included in the review. Across a median observation period of 12 months post-COVID, the overall incidence of NOD was about 1.82% in the COVID-infected group, compared to 0.35% in the non-COVID-infected group. The overall pooled meta-analysis showed a significantly increased NOD risk among COVID-19 older adult survivors compared to non-COVID-19 controls”
11 studies (involving 939,824 post-COVID-19 survivors and 6,765,117 controls) were included in the review. Across a median observation period of 12 months post-COVID, the overall incidence of NOD was about 1.82% in the COVID-infected group, compared to 0.35% in the non-COVID-infected group. The overall pooled meta-analysis showed a significantly increased NOD risk among COVID-19 older adult survivors compared to non-COVID-19 controls
Long COVID: SARS-CoV-2 spike protein accumulation linked to long-lasting brain effects
“The study shows that the SARS-CoV-2 spike protein remains in the brain's protective layers, the meninges, and the skull's bone marrow for up to four years after infection. This persistent presence of the spike protein could trigger chronic inflammation in affected individuals and increase the risk of neurodegenerative diseases.”
The study shows that the SARS-CoV-2 spike protein remains in the brain's protective layers, the meninges, and the skull's bone marrow for up to four years after infection. This persistent presence of the spike protein could trigger chronic inflammation in affected individuals and increase the risk of neurodegenerative diseases.
