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Molecular Imaging Findings on Acute and Long-Term Effects of COVID-19 on the Brain: A Systematic Review
Molecular Imaging Findings on Acute and Long-Term Effects of COVID-19 on the Brain: A Systematic Review
“Molecular imaging techniques such as PET and SPECT have been used to shed light on how coronavirus disease 2019 (COVID-19) affects the human brain. We provide a systematic review that summarizes the current literature according to 5 predominant topics.”
Molecular imaging techniques such as PET and SPECT have been used to shed light on how coronavirus disease 2019 (COVID-19) affects the human brain. We provide a systematic review that summarizes the current literature according to 5 predominant topics.
#Cognitive Impairment#Post-Acute Conditions#brain changes#brain#molecular changes#molecular
·pmc.ncbi.nlm.nih.gov·
Molecular Imaging Findings on Acute and Long-Term Effects of COVID-19 on the Brain: A Systematic Review
Systemic increase of AMPA receptors associated with cognitive impairment of long COVID | Brain Communications | Oxford Academic
Systemic increase of AMPA receptors associated with cognitive impairment of long COVID | Brain Communications | Oxford Academic
“Long COVID primarily presents with persistent cognitive impairment (Cog-LC), imposing a substantial and lasting global burden. Even after the pandemic, there remains a critical global need for diagnostic and therapeutic strategies targeting Cog-LC.”
Long COVID primarily presents with persistent cognitive impairment (Cog-LC), imposing a substantial and lasting global burden. Even after the pandemic, there remains a critical global need for diagnostic and therapeutic strategies targeting Cog-LC.
#Cognitive Impairment#Long Covid#brain#brain fog#Post-Acute Conditions
·academic.oup.com·
Systemic increase of AMPA receptors associated with cognitive impairment of long COVID | Brain Communications | Oxford Academic
New study reveals molecular basis of Long COVID brain fog
New study reveals molecular basis of Long COVID brain fog
“the researchers found a notable and widespread increase in the density of AMPARs across the brains of patients. This elevated receptor density was directly correlated with the severity of their cognitive impairment, suggesting a clear link between these molecular changes and the symptoms. Additionally, the concentrations of various inflammatory markers were also correlated with AMPAR levels, indicating a possible interaction between inflammation and receptor expression.”
#Long Covid#brain fog#Cognitive Impairment#cognition#brain#AMPARS#molecular#molecular changes#inflammation#Post-Acute Conditions
·news-medical.net·
New study reveals molecular basis of Long COVID brain fog
Thread by @JamesThrot on Thread Reader App
Thread by @JamesThrot on Thread Reader App

“Covid damages the part of your brain (frontal lobe) which is responsible for empathy, emotional regulation & overcoming self-centeredness.

This will facilitate immorality.

Each & every infection you have causes damage.

Many are on infection 4 (or more).

Signed, a neurologist.”

#Brain#Covid Isn't Over#Post-Acute Conditions#empathy#frontal lobe#Cognitive Impairment#brain dysfunction#cognition#James Throt#analysis#Discussion#compilations
·threadreaderapp.com·
Thread by @JamesThrot on Thread Reader App
It’s very frightening for many to even consider that #COVID infections are causing neurological damage but there are scans now. It’s impacting the frontal lobe. This is going to change society. The sooner we confront this the better or the damage will continue.🧵
It’s very frightening for many to even consider that #COVID infections are causing neurological damage but there are scans now. It’s impacting the frontal lobe. This is going to change society. The sooner we confront this the better or the damage will continue.🧵
“It’s very frightening for many to even consider that #COVID infections are causing neurological damage but there are scans now. It’s impacting the frontal lobe. This is going to change society. The sooner we confront this the better or the damage will continue.🧵”
#Brain#Post-Acute Conditions#frontal lobe injury#Cognitive Impairment#Covid Isn't Over#risks#Long Covid#Post-Acute Sequelae of COVID-19#brain dysfunction#cognitive decline#analysis#compilations#Discussion
·x.com·
It’s very frightening for many to even consider that #COVID infections are causing neurological damage but there are scans now. It’s impacting the frontal lobe. This is going to change society. The sooner we confront this the better or the damage will continue.🧵
Thread by @JamesThrot on Thread Reader App
Thread by @JamesThrot on Thread Reader App

“Let’s talk about COVID, brain damage & society.

Specifically, what happens when a neurotropic virus repeatedly infects the population, targeting the frontal lobe & almost nobody talks about the consequences?

This thread is for the skeptics.

I’m a neurologist, stay with me 🧵”

Let’s talk about COVID, brain damage & society. Specifically, what happens when a neurotropic virus repeatedly infects the population, targeting the frontal lobe & almost nobody talks about the consequences? This thread is for the skeptics. I’m a neurologist, stay with me 🧵
#Brain#Covid Isn't Over#Post-Acute Conditions#consequences#frontal lobe#brain dysfunction#cognition#cognitive decline#Long Covid#neurological#Post-Acute Sequelae of COVID-19#Cognitive Impairment#white matter#grey matter shrinkage#olfactory damage#working memory#Discussion#analysis#James Throt
·threadreaderapp.com·
Thread by @JamesThrot on Thread Reader App
Human challenge study reveals lasting cognitive decline after mild COVID-19
Human challenge study reveals lasting cognitive decline after mild COVID-19

“significant memory and executive function decline lasting up to a year, despite no reported subjective symptoms, prompting new questions about the virus’s long-term cognitive effects.”

Unvaccinated volunteers who contracted COVID-19 in a human challenge study showed
#cognitive decline#memory#long covid#cognition#Cognitive Impairment#Brain Fog#Long Covid#Post-Acute Conditions#Brain#neurological
·news-medical.net·
Human challenge study reveals lasting cognitive decline after mild COVID-19
Mapping brain changes in post-COVID-19 cognitive decline via FDG PET hypometabolism and EEG slowing
Mapping brain changes in post-COVID-19 cognitive decline via FDG PET hypometabolism and EEG slowing
Cognitive decline is a common symptom of post-COVID-19 syndrome. However, the mechanisms underlying this deficit remain poorly understood. This study aims to investigate the relationship between brain metabolic and neurophysiological alteration patterns in patients with persistent subjective cognitive decline after mild COVID-19 using joint FDG-PET and EEG analyses.
Cognitive decline is a common symptom of post-COVID-19 syndrome. However, the mechanisms underlying this deficit remain poorly understood. This study aims to investigate the relationship between brain metabolic and neurophysiological alteration patterns in patients with persistent subjective cognitive decline after mild COVID-19 using joint FDG-PET and EEG analyses.
#Cognitive Impairment#brain changes#cognitive decline#hypometabolism#Post-Acute Conditions#brain dysfunction#brain#neuroimaging#EEG slowing#cognition
·nature.com·
Mapping brain changes in post-COVID-19 cognitive decline via FDG PET hypometabolism and EEG slowing
Scientists find two brain biomarkers in long COVID sufferers that may be causing cognitive issues
Scientists find two brain biomarkers in long COVID sufferers that may be causing cognitive issues
“A new study that is the first to compare inflammation and brain stress responses in long COVID-19 patients with individuals who have fully recovered shows that those with continued brain fog and other cognitive issues have a lower ability to adapt to stress and higher levels of inflammation in their brains.”
A new study that is the first to compare inflammation and brain stress responses in long COVID-19 patients with individuals who have fully recovered shows that those with continued brain fog and other cognitive issues have a lower ability to adapt to stress and higher levels of inflammation in their brains.
#Neuroinflammation#brain inflammation#brain fog#cognition#Brain#Cognition#Cognitive Impairment#Long Covid
·medicalxpress.com·
Scientists find two brain biomarkers in long COVID sufferers that may be causing cognitive issues
Brain 18F-FDG PET imaging in outpatients with post-COVID-19 conditions: findings and associations with clinical characteristics
Brain 18F-FDG PET imaging in outpatients with post-COVID-19 conditions: findings and associations with clinical characteristics
“Outpatients with post-COVID-19 conditions exhibited extensive hypometabolic right fronto-temporal clusters. Patients with more numerous symptoms during the initial phase and with a longer duration of symptoms were at higher risk of persistent brain involvement.”
Outpatients with post-COVID-19 conditions exhibited extensive hypometabolic right fronto-temporal clusters. Patients with more numerous symptoms during the initial phase and with a longer duration of symptoms were at higher risk of persistent brain involvement.
#Long Covid#Post-Acute Conditions#brain#neuroimaging#hypometabolism#Cognitive Impairment#neurological
·link.springer.com·
Brain 18F-FDG PET imaging in outpatients with post-COVID-19 conditions: findings and associations with clinical characteristics
WTF DID SAM GET HIMSELF INTO?? | Hasanabi & Noah Kulwin React
WTF DID SAM GET HIMSELF INTO?? | Hasanabi & Noah Kulwin React
Starting at 4:15: “I’m becoming a bit of a Covid truther. I think we genuinely saw like an IQ drop across the board just of all the people who got hit with Covid. People’s brains I don’t think work as much or as well as they used to.”
#Discussion#Video#Brain#Covid History#brain injury#cognitive decline#cognitive disability#Cognitive Fatigue#Cognitive Impairment#cognition#working memory#IQ#anecdote
·youtube.com·
WTF DID SAM GET HIMSELF INTO?? | Hasanabi & Noah Kulwin React
Investigating the Neuroimmune, Cerebrovascular, and Cognitive Disturbances Associated with SARS‑CoV‑2 Infection: A Systematic Review of Post‑Acute Outcomes | Research Square
Investigating the Neuroimmune, Cerebrovascular, and Cognitive Disturbances Associated with SARS‑CoV‑2 Infection: A Systematic Review of Post‑Acute Outcomes | Research Square
“A systematic review of 73,435 COVID-19 survivors found that 42% had persistent neuroinflammation, 22% had cerebrovascular injury, and 58% had cognitive impairment.”
#Neuroinflammation#Post-Acute Conditions#neurological#Brain#Covid-19 Cognitive Impairment#Cognitive Impairment#cognition#cerebrovascular disease#vascular#cerebral blood flow#cerebrovascular injury
·researchsquare.com·
Investigating the Neuroimmune, Cerebrovascular, and Cognitive Disturbances Associated with SARS‑CoV‑2 Infection: A Systematic Review of Post‑Acute Outcomes | Research Square
COVID-19 may Enduringly Impact cognitive performance and brain haemodynamics in undergraduate students
COVID-19 may Enduringly Impact cognitive performance and brain haemodynamics in undergraduate students

“COVID-19 may Enduringly Impact cognitive performance and brain haemodynamics in undergraduate students”

“37 % of the undergraduates exhibited impaired cognition up to 17 months post-infection.”

#Brain#cognition#brain injury#Long Covid#Memory#cognitive decline#Cognitive Impairment#brain haemodynamics#young people#undergraduate students
·sciencedirect.com·
COVID-19 may Enduringly Impact cognitive performance and brain haemodynamics in undergraduate students
Association between COVID-19 infection and new-onset dementia in older adults: a systematic review and meta-analysis - BMC Geriatrics
Association between COVID-19 infection and new-onset dementia in older adults: a systematic review and meta-analysis - BMC Geriatrics
“11 studies (involving 939,824 post-COVID-19 survivors and 6,765,117 controls) were included in the review. Across a median observation period of 12 months post-COVID, the overall incidence of NOD was about 1.82% in the COVID-infected group, compared to 0.35% in the non-COVID-infected group. The overall pooled meta-analysis showed a significantly increased NOD risk among COVID-19 older adult survivors compared to non-COVID-19 controls”
11 studies (involving 939,824 post-COVID-19 survivors and 6,765,117 controls) were included in the review. Across a median observation period of 12 months post-COVID, the overall incidence of NOD was about 1.82% in the COVID-infected group, compared to 0.35% in the non-COVID-infected group. The overall pooled meta-analysis showed a significantly increased NOD risk among COVID-19 older adult survivors compared to non-COVID-19 controls
#Dementia#Cognitive Impairment#Neurological Complications#Brain#Covid-19 Cognitive Impairment#cognitive decline
·bmcgeriatr.biomedcentral.com·
Association between COVID-19 infection and new-onset dementia in older adults: a systematic review and meta-analysis - BMC Geriatrics
Long COVID: SARS-CoV-2 spike protein accumulation linked to long-lasting brain effects
Long COVID: SARS-CoV-2 spike protein accumulation linked to long-lasting brain effects
“The study shows that the SARS-CoV-2 spike protein remains in the brain's protective layers, the meninges, and the skull's bone marrow for up to four years after infection. This persistent presence of the spike protein could trigger chronic inflammation in affected individuals and increase the risk of neurodegenerative diseases.”
The study shows that the SARS-CoV-2 spike protein remains in the brain's protective layers, the meninges, and the skull's bone marrow for up to four years after infection. This persistent presence of the spike protein could trigger chronic inflammation in affected individuals and increase the risk of neurodegenerative diseases.
#Long Covid#Brain#Neuroinflammation#Cognitive Impairment#Viral Persistence#Post-Acute Sequelae of COVID-19#spike protein#meninges#cognition
·medicalxpress.com·
Long COVID: SARS-CoV-2 spike protein accumulation linked to long-lasting brain effects