Clinical and CSF single-cell profiling of post-COVID-19 cognitive impairment
we found that cognitive dysfunction is common; is not influenced by mood, fatigue, or sleepiness; and is correlated with MRI changes in very few people. In a subgroup that
Thread by @JamesThrot on Thread Reader App
“Let’s talk about COVID, brain damage & society.
Specifically, what happens when a neurotropic virus repeatedly infects the population, targeting the frontal lobe & almost nobody talks about the consequences?
This thread is for the skeptics.
I’m a neurologist, stay with me 🧵”
Let’s talk about COVID, brain damage & society.
Specifically, what happens when a neurotropic virus repeatedly infects the population, targeting the frontal lobe & almost nobody talks about the consequences?
This thread is for the skeptics.
I’m a neurologist, stay with me 🧵
Human challenge study reveals lasting cognitive decline after mild COVID-19
“significant memory and executive function decline lasting up to a year, despite no reported subjective symptoms, prompting new questions about the virus’s long-term cognitive effects.”
Unvaccinated volunteers who contracted COVID-19 in a human challenge study showed
Harry Spoelstra (@HarrySpoelstra) on X
Long-term neurological and cognitive impact of COVID-19: a systematic review and meta-analysis in over 4 million patients
The Molecular Mechanisms of Cognitive Dysfunction in Long COVID: A Narrative Review
The molecular mechanisms of cognitive dysfunction in Long COVID: A Narrative Review
Brain 18F-FDG PET imaging in outpatients with post-COVID-19 conditions: findings and associations with clinical characteristics
“Outpatients with post-COVID-19 conditions exhibited extensive hypometabolic right fronto-temporal clusters. Patients with more numerous symptoms during the initial phase and with a longer duration of symptoms were at higher risk of persistent brain involvement.”
Outpatients with post-COVID-19 conditions exhibited extensive hypometabolic right fronto-temporal clusters. Patients with more numerous symptoms during the initial phase and with a longer duration of symptoms were at higher risk of persistent brain involvement.
Investigating the Neuroimmune, Cerebrovascular, and Cognitive Disturbances Associated with SARS‑CoV‑2 Infection: A Systematic Review of Post‑Acute Outcomes | Research Square
“A systematic review of 73,435 COVID-19 survivors found that 42% had persistent neuroinflammation, 22% had cerebrovascular injury, and 58% had cognitive impairment.”