Cognitive decline is a common symptom of post-COVID-19 syndrome. However, the mechanisms underlying this deficit remain poorly understood. This study aims to investigate the relationship between brain metabolic and neurophysiological alteration patterns in patients with persistent subjective cognitive decline after mild COVID-19 using joint FDG-PET and EEG analyses.

Outpatients with post-COVID-19 conditions exhibited extensive hypometabolic right fronto-temporal clusters. Patients with more numerous symptoms during the initial phase and with a longer duration of symptoms were at higher risk of persistent brain involvement.