Found 19 bookmarks
Custom sorting
Thread by @JamesThrot on Thread Reader App
Thread by @JamesThrot on Thread Reader App

“Let’s talk about COVID, brain damage & society.

Specifically, what happens when a neurotropic virus repeatedly infects the population, targeting the frontal lobe & almost nobody talks about the consequences?

This thread is for the skeptics.

I’m a neurologist, stay with me 🧵”

Let’s talk about COVID, brain damage & society. Specifically, what happens when a neurotropic virus repeatedly infects the population, targeting the frontal lobe & almost nobody talks about the consequences? This thread is for the skeptics. I’m a neurologist, stay with me 🧵
·threadreaderapp.com·
Thread by @JamesThrot on Thread Reader App
Human challenge study reveals lasting cognitive decline after mild COVID-19
Human challenge study reveals lasting cognitive decline after mild COVID-19

“significant memory and executive function decline lasting up to a year, despite no reported subjective symptoms, prompting new questions about the virus’s long-term cognitive effects.”

Unvaccinated volunteers who contracted COVID-19 in a human challenge study showed
·news-medical.net·
Human challenge study reveals lasting cognitive decline after mild COVID-19
Frontiers | Serum angiotensin type-1 receptor autoantibodies and neurofilament light chain as markers of neuroaxonal damage in post-COVID patients
Frontiers | Serum angiotensin type-1 receptor autoantibodies and neurofilament light chain as markers of neuroaxonal damage in post-COVID patients
“Dysregulation of autoimmune responses and the presence of autoantibodies (AA), particularly those related to the renin-angiotensin system (RAS), have been implicated in the acute phase of COVID-19, and persistent dysregulation of brain RAS by RAS-related autoantibodies may also contribute to neurological symptoms of post-COVID.”
Dysregulation of autoimmune responses and the presence of autoantibodies (AA), particularly those related to the renin-angiotensin system (RAS), have been implicated in the acute phase of COVID-19, and persistent dysregulation of brain RAS by RAS-related autoantibodies may also contribute to neurological symptoms of post-COVID.
·frontiersin.org·
Frontiers | Serum angiotensin type-1 receptor autoantibodies and neurofilament light chain as markers of neuroaxonal damage in post-COVID patients
Brain 18F-FDG PET imaging in outpatients with post-COVID-19 conditions: findings and associations with clinical characteristics
Brain 18F-FDG PET imaging in outpatients with post-COVID-19 conditions: findings and associations with clinical characteristics
“Outpatients with post-COVID-19 conditions exhibited extensive hypometabolic right fronto-temporal clusters. Patients with more numerous symptoms during the initial phase and with a longer duration of symptoms were at higher risk of persistent brain involvement.”
Outpatients with post-COVID-19 conditions exhibited extensive hypometabolic right fronto-temporal clusters. Patients with more numerous symptoms during the initial phase and with a longer duration of symptoms were at higher risk of persistent brain involvement.
·link.springer.com·
Brain 18F-FDG PET imaging in outpatients with post-COVID-19 conditions: findings and associations with clinical characteristics
Altered auditory brainstem responses are post-acute sequela of SARS-CoV-2 (PASC)
Altered auditory brainstem responses are post-acute sequela of SARS-CoV-2 (PASC)
“PASC subjects showed an increased prevalence of tinnitus and more perceived hearing handicaps despite matched peripheral hearing ability, in addition to increased cognitive fatigue, anxiety, and depression.”
PASC subjects showed an increased prevalence of tinnitus and more perceived hearing handicaps despite matched peripheral hearing ability, in addition to increased cognitive fatigue, anxiety, and depression. ABR wave V latency differences between the slow and fast click r
·nature.com·
Altered auditory brainstem responses are post-acute sequela of SARS-CoV-2 (PASC)
Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19
Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19

Exploring the Persistence of the Spike Protein along the Skull-Meninges-Brain Axis and the Neurological Effects of COVID-19

This analysis is supported by numerous videos and illustrations.

·cell.com·
Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19
Neurological syndromes associated with COVID-19: a multicenter study in Brazil - BMC Infectious Diseases
Neurological syndromes associated with COVID-19: a multicenter study in Brazil - BMC Infectious Diseases
“197 patients were included, presenting with vascular syndromes (81), encephalopathy (68), encephalitis (19), Guillain-Barré syndrome (13), other neuropathies (12), and myelitis (4). The incidence curve of neurocovid mirrored that of COVID-19. Neurological syndromes were present regardless of COVID-19 severity. The median time from COVID-19 to onset of neurological symptoms was 14 days, suggesting a post-infectious immune-mediated mechanism.”
·flip.it·
Neurological syndromes associated with COVID-19: a multicenter study in Brazil - BMC Infectious Diseases
Long COVID Breakthrough: Spike Proteins Persist in Brain for Years
Long COVID Breakthrough: Spike Proteins Persist in Brain for Years
“A study reveals that the spike protein of SARS-CoV-2 remains in the brain long after infection, causing potential neurological issues and accelerated brain aging. mRNA vaccines help lower this risk but are not completely effective in eliminating the protein.”
A study reveals that the spike protein of SARS-CoV-2 remains in the brain long after infection, causing potential neurological issues and accelerated brain aging. mRNA vaccines help lower this risk but are not completely effective in eliminating the protein.
·scitechdaily.com·
Long COVID Breakthrough: Spike Proteins Persist in Brain for Years
Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19
Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19

Evidence that a COVID-19 infection can induce neurological sequelae.

The SARSCoV2 spike protein can persist in the brain—skull bone marrow and meninges—to induce neurologic damage

SARS-CoV-2 spike protein accumulates & persists in the body for years after infection, especially in the skull-meninges-brain axis, potentially driving long COVID. mRNA vaccines help but cannot stop it.

In mice, it caused inflammation, anxiety, and worsened brain injuries. Vaccines reduced but did not fully eliminate it.

SARS-CoV-2 spike protein persists in the skull-meninges-brain axis in COVID-19 patients•Spike protein is sufficient to induce brain pathological and behavioral changes in mice•Spike protein enhances brain vulnerability and exacerbates neurological damage in mice•mRNA vaccines reduce, but do not eliminate, the spike burden
·cell.com·
Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19
Cross-Section of Neurological Manifestations Among SARS-CoV-2 Omicron Subvariants—Single-Center Study
Cross-Section of Neurological Manifestations Among SARS-CoV-2 Omicron Subvariants—Single-Center Study

“The Omicron variant of SARS-CoV-2 presents a wide spectrum of neurological manifestations."

"Although there is an improvement in the survival rate of patients with COVID-19, the frequency of neurological manifestations increases."

"The occurrence of delirium, cerebrovascular diseases, and ischemic stroke results in higher mortality."

·mdpi.com·
Cross-Section of Neurological Manifestations Among SARS-CoV-2 Omicron Subvariants—Single-Center Study
SARS-CoV-2 Invasion and Pathological Links to Prion Disease
SARS-CoV-2 Invasion and Pathological Links to Prion Disease

Nearly half of those infected with SARS-CoV-2 experience long-term neurological problems, including brain fog and memory issues.

An infection may accelerate or exacerbate prion diseases like Creutzfeldt–Jakob disease, leading to rapid neurodegeneration.

·mdpi.com·
SARS-CoV-2 Invasion and Pathological Links to Prion Disease
Cognitive profile following COVID-19 infection: Clinical predictors leading to neuropsychological impairment
Cognitive profile following COVID-19 infection: Clinical predictors leading to neuropsychological impairment

Covid itself causes cognitive impairment. From 2020, prior to Covid vaccination of any kind:

“In our cohort of COVID-19 patients neurologic manifestations were frequent, including cognitive impairment.”

·sciencedirect.com·
Cognitive profile following COVID-19 infection: Clinical predictors leading to neuropsychological impairment
Driving Under the Cognitive Influence of COVID-19: Exploring the Impact of Acute SARS-CoV-2 Infection on Road Safety | Neurology
Driving Under the Cognitive Influence of COVID-19: Exploring the Impact of Acute SARS-CoV-2 Infection on Road Safety | Neurology
"The study suggests that acute COVID-19, regardless of Long COVID status, is linked to an increased risk of car crashes presumably due to neurologic changes caused by SARS-CoV-2."
·neurology.org·
Driving Under the Cognitive Influence of COVID-19: Exploring the Impact of Acute SARS-CoV-2 Infection on Road Safety | Neurology
Long COVID is not the same for everyone: a hierarchical cluster analysis of Long COVID symptoms 9 and 12 months after SARS-CoV-2 test - BMC Infectious Diseases
Long COVID is not the same for everyone: a hierarchical cluster analysis of Long COVID symptoms 9 and 12 months after SARS-CoV-2 test - BMC Infectious Diseases
“Our results suggest that Long COVID is not the same for everyone.”
Our results suggest that Long COVID is not the same for everyone.
·bmcinfectdis.biomedcentral.com·
Long COVID is not the same for everyone: a hierarchical cluster analysis of Long COVID symptoms 9 and 12 months after SARS-CoV-2 test - BMC Infectious Diseases
Low Cortisol Levels May Be Key to Long COVID Symptoms
Low Cortisol Levels May Be Key to Long COVID Symptoms

Yet another stretch for one size fits all explanation of a multifaceted condition. Still, important finding:

“A groundbreaking study from the University of Colorado Boulder has uncovered a potential mechanism behind the persistent neurological symptoms experienced by many Long COVID sufferers. The research, published in Brain, Behavior, and Immunity, points to a significant drop in cortisol levels in the brain as a possible culprit, offering new insights into this complex and widespread condition.”

·scienceblog.com·
Low Cortisol Levels May Be Key to Long COVID Symptoms