Alzheimer’s disease-like changes in COVID-19
Incidence of Bell Palsy in Patients With COVID-19
Known since 2021:
“Patients with COVID-19 can present with numerous otolaryngologic conditions, such as Bell palsy (BP)”
Patients with COVID-19 can present with numerous otolaryngologic conditions, such as Bell palsy (BP). Bell palsy is a unilateral peripheral facial nerve palsy of sudden onset. Several case reports and series have descri
Vaccination Does Not Impact Long COVID Neurological Symptoms
“Vaccination prior to COVID-19 infection does not significantly affect neurological symptoms in patients with postacute sequelae of SARS-CoV-2 infection, according to a study published online Jan. 7 in Brain Communications”
Vaccination prior to COVID-19 infection does not significantly affect neurological symptoms in patients with postacute sequelae of SARS-CoV-2 infection, according to a study published online Jan. 7 in Brain Communications.Shreya Mukherjee, from the Northwestern University Feinb
"The impact I am seeing on my clients post-COVID is something I hadn’t seen previously in the years I have worked in this field. The cognitive decline post-COVID infection is immense, thus confirming the impact this virus has on the brain..."
"The impact I am seeing on my clients post-COVID is something I hadn’t seen previously in the years I have worked in this field. The cognitive decline post-COVID infection is immense, thus confirming the impact this virus has on the brain..."
Clinical and radiological characteristics and 1-year self-reported outcomes from patients with encephalitis and coronavirus disease 2019 - Journal of Medical Case Reports
Amyloid-forming potential of Betacoronavirus including SARS-CoV-2
“Amyloid-forming potential of Betacoronavirus including SARS-CoV-2”
Amyloid-forming potential of Betacoronavirus including SARS-CoV-2
COVID-19 will never be like the Flu. Never.
“I have spent hundreds of hours in the microscope looking at the worst viruses can do to the brain, including the Zika virus, HIV, Flu, and others. I've never seen the type of damage SARS-CoV-2 leaves behind after infection with other viruses. “
Neurological complications after COVID-19: A narrative review
The widespread 🧠 neuro issues I’m witnessing can’t be overstated; a tipping point of previously healthy adults into early Parkinson’s/ GBS/ dementia/ ALS/ serious 👁️ issues/ strokes/ tremors/ vertigo / intractable anosmia & tinnitus etc
“The widespread 🧠 neuro issues I’m witnessing can’t be overstated; a tipping point of previously healthy adults into early Parkinson’s/ GBS/ dementia/ ALS/ serious 👁️ issues/ strokes/ tremors/ vertigo / intractable anosmia & tinnitus etc
An unparalleled horror show & crime.”
"Widespread use of metal caused estimated 2- to 3-point drop in IQ for nearly 180 years of Pax Romana"
"Widespread use of metal caused estimated 2- to 3-point drop in IQ for nearly 180 years of Pax Romana"
Meanwhile, #Covid in 5 years: "Participants with persistent symptoms had a 6-point loss in IQ, while those who had been admitted to an ICU experienced a 9-point loss in IQ."
Neuroimmune Dysfunction Facilitates COVID-19-Associated Neurological C
A review of the neurological manifestations of SARS-CoV-2 infection and long-term effects
Even mild COVID can cause brain shrinkage and affect mental function, new study shows
“Brain changes including shrinkage, weakened connections and poorer performance on thinking and memory tests could explain ‘brain fog’ after COVID – even after ‘mild’ cases.”
SARS-CoV-2 and HSV-1 Induce Amyloid Aggregation in Human CSF Resulting in Drastic Soluble Protein Depletion
SARS-CoV-2 and HSV-1 induce amyloid aggregation, depleting soluble proteins.
Suggests a link between viral infections and neurodegenerative diseases via protein loss.
COVID & the BRAIN… a thread 🧵
Hamsters with long Covid exhibits a neurodegenerative signature in the brainstem
“Using the golden hamster as a model, we provide further evidence that SARS-CoV-2 is neuroinvasive and can persist in the central nervous system, as we found viral RNA and replicative virus in the brainstem after 80 days of infection.”
Association between COVID-19 infection and new-onset dementia in older adults: a systematic review and meta-analysis - BMC Geriatrics
Older adults recovering from COVID-19 face a 58% higher risk of developing dementia compared to those uninfected, with rates peaking 12 months post-infection.
Study reviewed 11 studies, 940k cases, 6.8M controls.
Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19
Evidence that a COVID-19 infection can induce neurological sequelae.
The SARSCoV2 spike protein can persist in the brain—skull bone marrow and meninges—to induce neurologic damage
SARS-CoV-2 spike protein accumulates & persists in the body for years after infection, especially in the skull-meninges-brain axis, potentially driving long COVID. mRNA vaccines help but cannot stop it.
In mice, it caused inflammation, anxiety, and worsened brain injuries. Vaccines reduced but did not fully eliminate it.
Cognitive deficits after COVID-19 associated with brain injury biomarkers and volume loss
“Cognitive deficits after COVID-19 associated with brain injury biomarkers and volume loss”
Honestly it kinda pisses me off how some people act like we can't talk about the brain damage from Covid, especially on the population level.
“Honestly it kinda pisses me off how some people act like we can't talk about the brain damage from Covid, especially on the population level. Yes, it's important to consider the ableism. But I have brain damage from Covid, including to my emotions, and we need to talk about it...”
Frontiers | Frequency of Neurological Diseases After COVID-19, Influenza A/B and Bacterial Pneumonia
A study of electronic medical records of 35,362 COVID-19 outpatients in Denmark showed an increased relative risk (RR) of 3.5 for Alzheimer's disease and 2.6 for Parkinson's disease compared to outpatients who did not have COVID-19.
Cross-Section of Neurological Manifestations Among SARS-CoV-2 Omicron Subvariants—Single-Center Study
“The Omicron variant of SARS-CoV-2 presents a wide spectrum of neurological manifestations."
"Although there is an improvement in the survival rate of patients with COVID-19, the frequency of neurological manifestations increases."
"The occurrence of delirium, cerebrovascular diseases, and ischemic stroke results in higher mortality."
Part 2 of 2
Part 1 of 2
Why people can no longer drive.
Brain-wide alterations revealed by spatial transcriptomics and proteomics in COVID-19 infection
“We identified dysregulation of mitochondrial and synaptic pathways in deep-layer excitatory neurons and upregulation of neuroinflammation in glia, consistent across both mRNA and protein. Remarkably, these alterations overlapped substantially with changes in age-related neurodegenerative diseases, including Parkinson’s disease and Alzheimer’s disease”
We identified dysregulation of mitochondrial and synaptic pathways in deep-layer excitatory neurons and upregulation of neuroinflammation in glia, consistent across both mRNA and protein. Remarkably, these alterations overlapped substantially with changes in age-related neurodegenerative diseases, including Parkinson’s disease and Alzheimer’s disease
Cognition and Memory after Covid-19 in a Large Community Sample | NEJM
Cognition and Memory after Covid-19 in a Large Community Sample
Cognition and Memory after Covid-19 in a Large Community Sample
Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction - PubMed
“Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction”
Posthospitalization
If you’re not noticing the (obvious) cognitive impairment in practically everyone around you, it may be due to your own cognitive decline.
“If you’re not noticing the (obvious) cognitive impairment in practically everyone around you, it may be due to your own cognitive decline.
Or denial is rearing its ugly head once again.
Perhaps it’s easier for me considering my background, but honestly, it’s so bloody palpable.”
Mounting research shows that COVID-19 leaves its mark on the brain, including significant drops in IQ scores : r/news
“Mounting research shows that COVID-19 leaves its mark on the brain, including significant drops in IQ scores"
Frontiers | SARS-CoV-2 infection increases risk of intracranial hemorrhage
“SARS-CoV-2 infection increases risk of intracranial hemorrhage”
SARS-CoV-2 infection increases risk of intracranial hemorrhage
A case-control study of reaction time deficits in a 3D virtual reality in patients with Post-COVID syndrome
“A case-control study of reaction time deficits in a 3D virtual reality in patients with Post-COVID syndrome”
A case-control study of reaction time deficits in a 3D virtual reality in patients with Post-COVID syndrome