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Hamsters with long Covid exhibits a neurodegenerative signature in the brainstem
Hamsters with long Covid exhibits a neurodegenerative signature in the brainstem
“Using the golden hamster as a model, we provide further evidence that SARS-CoV-2 is neuroinvasive and can persist in the central nervous system, as we found viral RNA and replicative virus in the brainstem after 80 days of infection.”
·biorxiv.org·
Hamsters with long Covid exhibits a neurodegenerative signature in the brainstem
Association between COVID-19 infection and new-onset dementia in older adults: a systematic review and meta-analysis - BMC Geriatrics
Association between COVID-19 infection and new-onset dementia in older adults: a systematic review and meta-analysis - BMC Geriatrics

Older adults recovering from COVID-19 face a 58% higher risk of developing dementia compared to those uninfected, with rates peaking 12 months post-infection.

Study reviewed 11 studies, 940k cases, 6.8M controls.

·bmcgeriatr.biomedcentral.com·
Association between COVID-19 infection and new-onset dementia in older adults: a systematic review and meta-analysis - BMC Geriatrics
Long COVID: SARS-CoV-2 spike protein accumulation linked to long-lasting brain effects
Long COVID: SARS-CoV-2 spike protein accumulation linked to long-lasting brain effects
“The study shows that the SARS-CoV-2 spike protein remains in the brain's protective layers, the meninges, and the skull's bone marrow for up to four years after infection. This persistent presence of the spike protein could trigger chronic inflammation in affected individuals and increase the risk of neurodegenerative diseases.”
The study shows that the SARS-CoV-2 spike protein remains in the brain's protective layers, the meninges, and the skull's bone marrow for up to four years after infection. This persistent presence of the spike protein could trigger chronic inflammation in affected individuals and increase the risk of neurodegenerative diseases.
·medicalxpress.com·
Long COVID: SARS-CoV-2 spike protein accumulation linked to long-lasting brain effects
Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19
Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19

Evidence that a COVID-19 infection can induce neurological sequelae.

The SARSCoV2 spike protein can persist in the brain—skull bone marrow and meninges—to induce neurologic damage

SARS-CoV-2 spike protein accumulates & persists in the body for years after infection, especially in the skull-meninges-brain axis, potentially driving long COVID. mRNA vaccines help but cannot stop it.

In mice, it caused inflammation, anxiety, and worsened brain injuries. Vaccines reduced but did not fully eliminate it.

·cell.com·
Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19
Honestly it kinda pisses me off how some people act like we can't talk about the brain damage from Covid, especially on the population level.
Honestly it kinda pisses me off how some people act like we can't talk about the brain damage from Covid, especially on the population level.

“Honestly it kinda pisses me off how some people act like we can't talk about the brain damage from Covid, especially on the population level. Yes, it's important to consider the ableism. But I have brain damage from Covid, including to my emotions, and we need to talk about it...”

·x.com·
Honestly it kinda pisses me off how some people act like we can't talk about the brain damage from Covid, especially on the population level.
Cross-Section of Neurological Manifestations Among SARS-CoV-2 Omicron Subvariants—Single-Center Study
Cross-Section of Neurological Manifestations Among SARS-CoV-2 Omicron Subvariants—Single-Center Study

“The Omicron variant of SARS-CoV-2 presents a wide spectrum of neurological manifestations."

"Although there is an improvement in the survival rate of patients with COVID-19, the frequency of neurological manifestations increases."

"The occurrence of delirium, cerebrovascular diseases, and ischemic stroke results in higher mortality."

·mdpi.com·
Cross-Section of Neurological Manifestations Among SARS-CoV-2 Omicron Subvariants—Single-Center Study
We Just Got More Evidence That Long COVID Is a Brain Injury
We Just Got More Evidence That Long COVID Is a Brain Injury

“Signs of brain inflammation were present up to 18 months after first contracting the SARS-CoV-2 virus.

‘We show that the brainstem is a site of vulnerability to long-term effects of COVID-19, with persistent changes evident in the months after hospitalization,’ the authors of the study conclude.”

Signs of brain inflammation were present up to 18 months after first contracting the SARS-CoV-2 virus. if ('undefined' !== typeof window.tmntag && 'undefined' !== typeof window.tmntag.cmd) { tmntag.cmd.push(function () { tmntag.adTag('Purch_Y_C_0_2', false); }); } "We show that the brainstem is a site of vulnerability to long-term effects of COVID-19, with persistent changes evident in the months after hospitalization," the authors of the study conclude.
·sciencealert.com·
We Just Got More Evidence That Long COVID Is a Brain Injury
A case-control study of reaction time deficits in a 3D virtual reality in patients with Post-COVID syndrome
A case-control study of reaction time deficits in a 3D virtual reality in patients with Post-COVID syndrome
“A case-control study of reaction time deficits in a 3D virtual reality in patients with Post-COVID syndrome”
A case-control study of reaction time deficits in a 3D virtual reality in patients with Post-COVID syndrome
·nature.com·
A case-control study of reaction time deficits in a 3D virtual reality in patients with Post-COVID syndrome
Limbic system damage following SARS-CoV2 infection | Brain Communications | Oxford Academic
Limbic system damage following SARS-CoV2 infection | Brain Communications | Oxford Academic

Limbic system damage from Covid:

SARS-CoV-2 is a neurotropic virus that may cause long-term neurological symptoms by damaging the limbic system.

This research shows that COVID-19 can impair emotion recognition, memory, and olfactory abilities, with altered brain connectivity patterns.

·academic.oup.com·
Limbic system damage following SARS-CoV2 infection | Brain Communications | Oxford Academic
SARS-CoV-2 Invasion and Pathological Links to Prion Disease
SARS-CoV-2 Invasion and Pathological Links to Prion Disease

Nearly half of those infected with SARS-CoV-2 experience long-term neurological problems, including brain fog and memory issues.

An infection may accelerate or exacerbate prion diseases like Creutzfeldt–Jakob disease, leading to rapid neurodegeneration.

·mdpi.com·
SARS-CoV-2 Invasion and Pathological Links to Prion Disease
Worse, most people don’t even notice it has happened to themselves.
Worse, most people don’t even notice it has happened to themselves.

“Worse, most people don’t even notice it has happened to themselves.

But I can tell you we who continue to mask and have many fewer COVID infections can see the growing cognitive damage in more and more people around us.

Memory problems, like recall and word finding delays. Weakness and fatigue and motor control impairment. Growing executive function and emotional regulation deficits.

More and more friends disables and forced out of work or school by Long COVID symptoms.

It’s scary to witness the broad societal decline, and dispiriting to see so many governments and Public Health agencies persist in minimizing the growing problem.”

·x.com·
Worse, most people don’t even notice it has happened to themselves.
Cognitive profile following COVID-19 infection: Clinical predictors leading to neuropsychological impairment
Cognitive profile following COVID-19 infection: Clinical predictors leading to neuropsychological impairment

Covid itself causes cognitive impairment. From 2020, prior to Covid vaccination of any kind:

“In our cohort of COVID-19 patients neurologic manifestations were frequent, including cognitive impairment.”

·sciencedirect.com·
Cognitive profile following COVID-19 infection: Clinical predictors leading to neuropsychological impairment
COVID survivors may develop dementia
COVID survivors may develop dementia

“COVID-19 survivors show signs of significant cognitive deficits which could become dementia even a year after having the virus.. The team [in India] found that more than 80% of people tested reported at least one of four symptoms – depression, anxiety, stress and insomnia – ranging from mild to severe.. At least 6.1% of the patients were diagnosed with mild cognitive impairment and 4% developed dementia. More than 60% of the patients experienced a loss of taste and smell during the active phase of the infection. This could alter the function of brain areas linked to cognitive ability and emotional well-being.."

COVID-19 survivors show signs of significant cognitive deficits which could become dementia even a year after having the virus1. They also have an increased risk of depression, anxiety and disrupted sleep.
·nature.com·
COVID survivors may develop dementia
Advanced brain fMRI showed low glutathione : r/covidlonghaulers
Advanced brain fMRI showed low glutathione : r/covidlonghaulers

“Hey all. I thought I would just throw this out there. I had an advanced brain fMRI that was able to show a bunch of brain biomarkers. The only significant finding was that I had low brain glutathione. I was at .56 mM and the normal range is 1-2 mM. He told me this is a large deficiency.

He said this would usually indicate CFS, brain fog, and low energy.”

·reddit.com·
Advanced brain fMRI showed low glutathione : r/covidlonghaulers
Quantitative susceptibility mapping at 7 T in COVID-19: brainstem effects and outcome associations | Brain | Oxford Academic
Quantitative susceptibility mapping at 7 T in COVID-19: brainstem effects and outcome associations | Brain | Oxford Academic
“In COVID-19 survivors, the MR susceptibility increased in the medulla, pons and midbrain regions of the brainstem. Specifically, there was increased susceptibility in the inferior medullary reticular formation and the raphe pallidus and obscurus. In these regions, patients with higher tissue susceptibility had worse acute disease severity, higher acute inflammatory markers, and significantly worse functional recovery.”
In COVID-19 survivors, the MR susceptibility increased in the medulla, pons and midbrain regions of the brainstem. Specifically, there was increased susceptibility in the inferior medullary reticular formation and the raphe pallidus and obscurus. In these regions, patients with higher tissue susceptibility had worse acute disease severity, higher acute inflammatory markers, and significantly worse functional recovery.
·academic.oup.com·
Quantitative susceptibility mapping at 7 T in COVID-19: brainstem effects and outcome associations | Brain | Oxford Academic
Driving Under the Cognitive Influence of COVID-19: Exploring the Impact of Acute SARS-CoV-2 Infection on Road Safety | Neurology
Driving Under the Cognitive Influence of COVID-19: Exploring the Impact of Acute SARS-CoV-2 Infection on Road Safety | Neurology
"The study suggests that acute COVID-19, regardless of Long COVID status, is linked to an increased risk of car crashes presumably due to neurologic changes caused by SARS-CoV-2."
·neurology.org·
Driving Under the Cognitive Influence of COVID-19: Exploring the Impact of Acute SARS-CoV-2 Infection on Road Safety | Neurology
And no, I could not smell the vinegar. My smell/taste disappeared post-Covid in 2020. I got reinfected in 2022 & my taste returned, but I don’t think my sense of smell will never be the same again. But anyway, everyone should keep “coexisting” with Covid! Make sure your kids get…
And no, I could not smell the vinegar. My smell/taste disappeared post-Covid in 2020. I got reinfected in 2022 & my taste returned, but I don’t think my sense of smell will never be the same again. But anyway, everyone should keep “coexisting” with Covid! Make sure your kids get…
“And no, I could not smell the vinegar. My smell/taste disappeared post-Covid in 2020. I got reinfected in 2022 & my taste returned, but I don’t think my sense of smell will never be the same again. But anyway, everyone should keep “coexisting” with Covid! Make sure your kids get it a lot too!”
·x.com·
And no, I could not smell the vinegar. My smell/taste disappeared post-Covid in 2020. I got reinfected in 2022 & my taste returned, but I don’t think my sense of smell will never be the same again. But anyway, everyone should keep “coexisting” with Covid! Make sure your kids get…
Whoopi Goldberg Commiserates With Fellow-Covid Sufferer Joe Biden: “Sometimes I Go For A Word And It’s Not There”
Whoopi Goldberg Commiserates With Fellow-Covid Sufferer Joe Biden: “Sometimes I Go For A Word And It’s Not There”

Whoopi Goldberg, who just had her 4th COVID infection, joked about her post infection brain damage on TV.

“I’m just getting over COVID – again – and I can barely remember anybody’s name. There are times when I go for a word and it’s not there.”

·deadline.com·
Whoopi Goldberg Commiserates With Fellow-Covid Sufferer Joe Biden: “Sometimes I Go For A Word And It’s Not There”
Emerging signs of Alzheimer‐like tau hyperphosphorylation and neuroinflammation in the brain post recovery from COVID‐19
Emerging signs of Alzheimer‐like tau hyperphosphorylation and neuroinflammation in the brain post recovery from COVID‐19
Emerging signs of Alzheimer’s-like pathology in brains if people recovered from COVID-19, even though no direct SARS-CoV-2 invasion was detected
·onlinelibrary.wiley.com·
Emerging signs of Alzheimer‐like tau hyperphosphorylation and neuroinflammation in the brain post recovery from COVID‐19