Thread by @JamesThrot on Thread Reader App
“SARS-CoV-2 isn’t just a respiratory virus. Emerging evidence shows it can infect human motor neurons. Could this link to motor neuron disease (MND)?”
SARS-CoV-2 can infect and replicate in human motor neurons
SARS-CoV-2 can enter human motor neurons primarily through the receptors CD147 and NRP1.
The infection alters the expression of several genes involved in cell survival, metabolism, inflammatory response, and antiviral pathways.