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Systemic increase of AMPA receptors associated with cognitive impairment of long COVID | Brain Communications | Oxford Academic
Systemic increase of AMPA receptors associated with cognitive impairment of long COVID | Brain Communications | Oxford Academic
“Long COVID primarily presents with persistent cognitive impairment (Cog-LC), imposing a substantial and lasting global burden. Even after the pandemic, there remains a critical global need for diagnostic and therapeutic strategies targeting Cog-LC.”
Long COVID primarily presents with persistent cognitive impairment (Cog-LC), imposing a substantial and lasting global burden. Even after the pandemic, there remains a critical global need for diagnostic and therapeutic strategies targeting Cog-LC.
#Cognitive Impairment#Long Covid#brain#brain fog#Post-Acute Conditions
·academic.oup.com·
Systemic increase of AMPA receptors associated with cognitive impairment of long COVID | Brain Communications | Oxford Academic
New study reveals molecular basis of Long COVID brain fog
New study reveals molecular basis of Long COVID brain fog
“the researchers found a notable and widespread increase in the density of AMPARs across the brains of patients. This elevated receptor density was directly correlated with the severity of their cognitive impairment, suggesting a clear link between these molecular changes and the symptoms. Additionally, the concentrations of various inflammatory markers were also correlated with AMPAR levels, indicating a possible interaction between inflammation and receptor expression.”
#Long Covid#brain fog#Cognitive Impairment#cognition#brain#AMPARS#molecular#molecular changes#inflammation#Post-Acute Conditions
·news-medical.net·
New study reveals molecular basis of Long COVID brain fog
6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health records - PubMed
6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health records - PubMed
COVID-19 convalescents had a greater likelihood of developing Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and stroke 6 months after infection, as compared to those affected by influenza or any other respiratory infections.
#Long Covid#Post-Acute Conditions#neurological#Brain#Parkinsons#Alzheimers#Stroke#Respiratory Illnesses#Multiple Sclerosis#consequences
·pubmed.ncbi.nlm.nih.gov·
6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health records - PubMed
An Amyloidogenic Fragment of the Spike Protein from SARS-CoV-2 Virus Stimulates the Aggregation and Toxicity of Parkinson’s Disease Protein Alpha-Synuclein
An Amyloidogenic Fragment of the Spike Protein from SARS-CoV-2 Virus Stimulates the Aggregation and Toxicity of Parkinson’s Disease Protein Alpha-Synuclein
“Overall, our findings raise compelling questions about the potential role of SARS-CoV-2 infection in accelerating or triggering neurodegenerative diseases linked to protein amyloidosis”
#Neurodegenerative#amyloid aggregation#neurological#Neuroinflammation#spike protein#Long Covid#Parkinsons#brain#Post-Acute Conditions
·pubs.acs.org·
An Amyloidogenic Fragment of the Spike Protein from SARS-CoV-2 Virus Stimulates the Aggregation and Toxicity of Parkinson’s Disease Protein Alpha-Synuclein
It’s very frightening for many to even consider that #COVID infections are causing neurological damage but there are scans now. It’s impacting the frontal lobe. This is going to change society. The sooner we confront this the better or the damage will continue.🧵
It’s very frightening for many to even consider that #COVID infections are causing neurological damage but there are scans now. It’s impacting the frontal lobe. This is going to change society. The sooner we confront this the better or the damage will continue.🧵
“It’s very frightening for many to even consider that #COVID infections are causing neurological damage but there are scans now. It’s impacting the frontal lobe. This is going to change society. The sooner we confront this the better or the damage will continue.🧵”
#Brain#Post-Acute Conditions#frontal lobe injury#Cognitive Impairment#Covid Isn't Over#risks#Long Covid#Post-Acute Sequelae of COVID-19#brain dysfunction#cognitive decline#analysis#compilations#Discussion
·x.com·
It’s very frightening for many to even consider that #COVID infections are causing neurological damage but there are scans now. It’s impacting the frontal lobe. This is going to change society. The sooner we confront this the better or the damage will continue.🧵
Thread by @JamesThrot on Thread Reader App
Thread by @JamesThrot on Thread Reader App

“Let’s talk about COVID, brain damage & society.

Specifically, what happens when a neurotropic virus repeatedly infects the population, targeting the frontal lobe & almost nobody talks about the consequences?

This thread is for the skeptics.

I’m a neurologist, stay with me 🧵”

Let’s talk about COVID, brain damage & society. Specifically, what happens when a neurotropic virus repeatedly infects the population, targeting the frontal lobe & almost nobody talks about the consequences? This thread is for the skeptics. I’m a neurologist, stay with me 🧵
#Brain#Covid Isn't Over#Post-Acute Conditions#consequences#frontal lobe#brain dysfunction#cognition#cognitive decline#Long Covid#neurological#Post-Acute Sequelae of COVID-19#Cognitive Impairment#white matter#grey matter shrinkage#olfactory damage#working memory#Discussion#analysis#James Throt
·threadreaderapp.com·
Thread by @JamesThrot on Thread Reader App
Human challenge study reveals lasting cognitive decline after mild COVID-19
Human challenge study reveals lasting cognitive decline after mild COVID-19

“significant memory and executive function decline lasting up to a year, despite no reported subjective symptoms, prompting new questions about the virus’s long-term cognitive effects.”

Unvaccinated volunteers who contracted COVID-19 in a human challenge study showed
#cognitive decline#memory#long covid#cognition#Cognitive Impairment#Brain Fog#Long Covid#Post-Acute Conditions#Brain#neurological
·news-medical.net·
Human challenge study reveals lasting cognitive decline after mild COVID-19
Frontiers | Serum angiotensin type-1 receptor autoantibodies and neurofilament light chain as markers of neuroaxonal damage in post-COVID patients
Frontiers | Serum angiotensin type-1 receptor autoantibodies and neurofilament light chain as markers of neuroaxonal damage in post-COVID patients
“Dysregulation of autoimmune responses and the presence of autoantibodies (AA), particularly those related to the renin-angiotensin system (RAS), have been implicated in the acute phase of COVID-19, and persistent dysregulation of brain RAS by RAS-related autoantibodies may also contribute to neurological symptoms of post-COVID.”
Dysregulation of autoimmune responses and the presence of autoantibodies (AA), particularly those related to the renin-angiotensin system (RAS), have been implicated in the acute phase of COVID-19, and persistent dysregulation of brain RAS by RAS-related autoantibodies may also contribute to neurological symptoms of post-COVID.
#autoimmunity#neurological#Post-Acute Conditions#Long Covid#Immune system#brain#Neuroaxonal damage
·frontiersin.org·
Frontiers | Serum angiotensin type-1 receptor autoantibodies and neurofilament light chain as markers of neuroaxonal damage in post-COVID patients
Scientists find two brain biomarkers in long COVID sufferers that may be causing cognitive issues
Scientists find two brain biomarkers in long COVID sufferers that may be causing cognitive issues
“A new study that is the first to compare inflammation and brain stress responses in long COVID-19 patients with individuals who have fully recovered shows that those with continued brain fog and other cognitive issues have a lower ability to adapt to stress and higher levels of inflammation in their brains.”
A new study that is the first to compare inflammation and brain stress responses in long COVID-19 patients with individuals who have fully recovered shows that those with continued brain fog and other cognitive issues have a lower ability to adapt to stress and higher levels of inflammation in their brains.
#Neuroinflammation#brain inflammation#brain fog#cognition#Brain#Cognition#Cognitive Impairment#Long Covid
·medicalxpress.com·
Scientists find two brain biomarkers in long COVID sufferers that may be causing cognitive issues
How COVID Impacts the Brain: Danielle Beckman and David Joffe
How COVID Impacts the Brain: Danielle Beckman and David Joffe
“How does COVID-19 impact the brain? Neuroscientist Danielle Beckman and expert David Joffe discuss direct neuronal effects and sleep disorders in Long COVID patients, and the importance of thorough evaluations for accurate diagnoses.”
#Brain#Cognitive decline#Long Covid#Memory#neurodegeneration#brain#neuronal effects#sleep#sleep disturbances#David Joffe#video#Danielle Beckman#podcast
·youtube.com·
How COVID Impacts the Brain: Danielle Beckman and David Joffe
Brain 18F-FDG PET imaging in outpatients with post-COVID-19 conditions: findings and associations with clinical characteristics
Brain 18F-FDG PET imaging in outpatients with post-COVID-19 conditions: findings and associations with clinical characteristics
“Outpatients with post-COVID-19 conditions exhibited extensive hypometabolic right fronto-temporal clusters. Patients with more numerous symptoms during the initial phase and with a longer duration of symptoms were at higher risk of persistent brain involvement.”
Outpatients with post-COVID-19 conditions exhibited extensive hypometabolic right fronto-temporal clusters. Patients with more numerous symptoms during the initial phase and with a longer duration of symptoms were at higher risk of persistent brain involvement.
#Long Covid#Post-Acute Conditions#brain#neuroimaging#hypometabolism#Cognitive Impairment#neurological
·link.springer.com·
Brain 18F-FDG PET imaging in outpatients with post-COVID-19 conditions: findings and associations with clinical characteristics
Altered auditory brainstem responses are post-acute sequela of SARS-CoV-2 (PASC)
Altered auditory brainstem responses are post-acute sequela of SARS-CoV-2 (PASC)
“PASC subjects showed an increased prevalence of tinnitus and more perceived hearing handicaps despite matched peripheral hearing ability, in addition to increased cognitive fatigue, anxiety, and depression.”
PASC subjects showed an increased prevalence of tinnitus and more perceived hearing handicaps despite matched peripheral hearing ability, in addition to increased cognitive fatigue, anxiety, and depression. ABR wave V latency differences between the slow and fast click r
#Ears#Post-Acute Conditions#Auditory System#Long Covid#Brain#PASC#neurological#long covid#hearing loss#tinnitus#Fatigue#ANA test#Depression#cognitive decline
·nature.com·
Altered auditory brainstem responses are post-acute sequela of SARS-CoV-2 (PASC)
Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19
Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19

Exploring the Persistence of the Spike Protein along the Skull-Meninges-Brain Axis and the Neurological Effects of COVID-19

This analysis is supported by numerous videos and illustrations.

#Brain#Long Covid#Neuroinflammation#Post-Acute Conditions#brain injury#meninges#neurologic changes#neurological#spike protein#skull
·cell.com·
Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19
Structural brain changes in post-COVID condition and its relationship with cognitive impairment | Brain Communications | Oxford Academic
Structural brain changes in post-COVID condition and its relationship with cognitive impairment | Brain Communications | Oxford Academic
Structural brain changes in post-COVID condition and its relationship with cognitive impairment
#Brain#Brain shrinkage#brain atrophy#Long Covid#Post-Acute Conditions#cognitive decline#cognition#organ damage
·academic.oup.com·
Structural brain changes in post-COVID condition and its relationship with cognitive impairment | Brain Communications | Oxford Academic