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6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health records - PubMed
6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health records - PubMed
COVID-19 convalescents had a greater likelihood of developing Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and stroke 6 months after infection, as compared to those affected by influenza or any other respiratory infections.
·pubmed.ncbi.nlm.nih.gov·
6-month neurological and psychiatric outcomes in 236 379 survivors of COVID-19: a retrospective cohort study using electronic health records - PubMed
An Amyloidogenic Fragment of the Spike Protein from SARS-CoV-2 Virus Stimulates the Aggregation and Toxicity of Parkinson’s Disease Protein Alpha-Synuclein
An Amyloidogenic Fragment of the Spike Protein from SARS-CoV-2 Virus Stimulates the Aggregation and Toxicity of Parkinson’s Disease Protein Alpha-Synuclein
“Overall, our findings raise compelling questions about the potential role of SARS-CoV-2 infection in accelerating or triggering neurodegenerative diseases linked to protein amyloidosis”
·pubs.acs.org·
An Amyloidogenic Fragment of the Spike Protein from SARS-CoV-2 Virus Stimulates the Aggregation and Toxicity of Parkinson’s Disease Protein Alpha-Synuclein
Neuropsychiatric Risks Linked to COVID-19 Revealed
Neuropsychiatric Risks Linked to COVID-19 Revealed

New Nature study shows SARS2 significantly elevates the risk of neuropsychiatric conditions including anxiety, mood disorders, cognitive impairment and psychotic disorders for up to 6 months.

“Alarmingly, even individuals with mild or asymptomatic infections face elevated risk.”

·bioengineer.org·
Neuropsychiatric Risks Linked to COVID-19 Revealed
Thread by @JamesThrot on Thread Reader App
Thread by @JamesThrot on Thread Reader App

“Let’s talk about COVID, brain damage & society.

Specifically, what happens when a neurotropic virus repeatedly infects the population, targeting the frontal lobe & almost nobody talks about the consequences?

This thread is for the skeptics.

I’m a neurologist, stay with me 🧵”

Let’s talk about COVID, brain damage & society. Specifically, what happens when a neurotropic virus repeatedly infects the population, targeting the frontal lobe & almost nobody talks about the consequences? This thread is for the skeptics. I’m a neurologist, stay with me 🧵
·threadreaderapp.com·
Thread by @JamesThrot on Thread Reader App
Human challenge study reveals lasting cognitive decline after mild COVID-19
Human challenge study reveals lasting cognitive decline after mild COVID-19

“significant memory and executive function decline lasting up to a year, despite no reported subjective symptoms, prompting new questions about the virus’s long-term cognitive effects.”

Unvaccinated volunteers who contracted COVID-19 in a human challenge study showed
·news-medical.net·
Human challenge study reveals lasting cognitive decline after mild COVID-19
Frontiers | Serum angiotensin type-1 receptor autoantibodies and neurofilament light chain as markers of neuroaxonal damage in post-COVID patients
Frontiers | Serum angiotensin type-1 receptor autoantibodies and neurofilament light chain as markers of neuroaxonal damage in post-COVID patients
“Dysregulation of autoimmune responses and the presence of autoantibodies (AA), particularly those related to the renin-angiotensin system (RAS), have been implicated in the acute phase of COVID-19, and persistent dysregulation of brain RAS by RAS-related autoantibodies may also contribute to neurological symptoms of post-COVID.”
Dysregulation of autoimmune responses and the presence of autoantibodies (AA), particularly those related to the renin-angiotensin system (RAS), have been implicated in the acute phase of COVID-19, and persistent dysregulation of brain RAS by RAS-related autoantibodies may also contribute to neurological symptoms of post-COVID.
·frontiersin.org·
Frontiers | Serum angiotensin type-1 receptor autoantibodies and neurofilament light chain as markers of neuroaxonal damage in post-COVID patients
Unusual Post–COVID-19 Presentation With Tetraventricular Hydrocephalus | Neurology Clinical Practice
Unusual Post–COVID-19 Presentation With Tetraventricular Hydrocephalus | Neurology Clinical Practice
“COVID-19 infection is suggested as one of the causes for hydrocephalus (HCP) of unknown etiology. “
COVID-19 infection is suggested as one of the causes for hydrocephalus (HCP) of unknown etiology.
·neurology.org·
Unusual Post–COVID-19 Presentation With Tetraventricular Hydrocephalus | Neurology Clinical Practice
Multimodal MRI analysis of COVID-19 effects on pediatric brain
Multimodal MRI analysis of COVID-19 effects on pediatric brain

Even mild Covid changes children’s brains.

“We speculate that viral-triggered neuroinflammation and immune response contribute to neurotoxic damage in brain regions involved in cognitive processing, ultimately resulting in alterations in cortical morphology and glymphatic function.”

We speculate that viral-triggered neuroinflammation and immune response contribute to neurotoxic damage in brain regions involved in cognitive processing, ultimately resulting in alterations in cortical morphology and glymphatic function.
·nature.com·
Multimodal MRI analysis of COVID-19 effects on pediatric brain
newsGP - How COVID-19 leaves its mark on the brain
newsGP - How COVID-19 leaves its mark on the brain
“Mounting research shows the disease can lead to an array of problems, including significant drops in IQ scores, writes Dr Ziyad Al-Aly.”
Mounting research shows the disease can lead to an array of problems, including significant drops in IQ scores, writes Dr Ziyad Al-Aly.
·www1.racgp.org.au·
newsGP - How COVID-19 leaves its mark on the brain
Brain 18F-FDG PET imaging in outpatients with post-COVID-19 conditions: findings and associations with clinical characteristics
Brain 18F-FDG PET imaging in outpatients with post-COVID-19 conditions: findings and associations with clinical characteristics
“Outpatients with post-COVID-19 conditions exhibited extensive hypometabolic right fronto-temporal clusters. Patients with more numerous symptoms during the initial phase and with a longer duration of symptoms were at higher risk of persistent brain involvement.”
Outpatients with post-COVID-19 conditions exhibited extensive hypometabolic right fronto-temporal clusters. Patients with more numerous symptoms during the initial phase and with a longer duration of symptoms were at higher risk of persistent brain involvement.
·link.springer.com·
Brain 18F-FDG PET imaging in outpatients with post-COVID-19 conditions: findings and associations with clinical characteristics
Altered auditory brainstem responses are post-acute sequela of SARS-CoV-2 (PASC)
Altered auditory brainstem responses are post-acute sequela of SARS-CoV-2 (PASC)
“PASC subjects showed an increased prevalence of tinnitus and more perceived hearing handicaps despite matched peripheral hearing ability, in addition to increased cognitive fatigue, anxiety, and depression.”
PASC subjects showed an increased prevalence of tinnitus and more perceived hearing handicaps despite matched peripheral hearing ability, in addition to increased cognitive fatigue, anxiety, and depression. ABR wave V latency differences between the slow and fast click r
·nature.com·
Altered auditory brainstem responses are post-acute sequela of SARS-CoV-2 (PASC)
Investigating the Neuroimmune, Cerebrovascular, and Cognitive Disturbances Associated with SARS‑CoV‑2 Infection: A Systematic Review of Post‑Acute Outcomes | Research Square
Investigating the Neuroimmune, Cerebrovascular, and Cognitive Disturbances Associated with SARS‑CoV‑2 Infection: A Systematic Review of Post‑Acute Outcomes | Research Square
“A systematic review of 73,435 COVID-19 survivors found that 42% had persistent neuroinflammation, 22% had cerebrovascular injury, and 58% had cognitive impairment.”
·researchsquare.com·
Investigating the Neuroimmune, Cerebrovascular, and Cognitive Disturbances Associated with SARS‑CoV‑2 Infection: A Systematic Review of Post‑Acute Outcomes | Research Square
Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19
Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19

Exploring the Persistence of the Spike Protein along the Skull-Meninges-Brain Axis and the Neurological Effects of COVID-19

This analysis is supported by numerous videos and illustrations.

·cell.com·
Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19
Correct ✅ Covid 19 is causing widespread brain damage on a global scale. SARS-CoV-2 damages the brain. FACT. Brain fog, memory issues, more mistakes/crashes/accidents, less empathy, worsening mental health/emotional regulation. The signs are clear. Signed, a neurologist 🧵 https://t.co/CI5p3RsXBu pic.twitter.com/2yMIk966QA— James Throt MBBS, MD, PhD, FRCPath (@JamesThrot) February 14, 2025
Correct ✅ Covid 19 is causing widespread brain damage on a global scale. SARS-CoV-2 damages the brain. FACT. Brain fog, memory issues, more mistakes/crashes/accidents, less empathy, worsening mental health/emotional regulation. The signs are clear. Signed, a neurologist 🧵 https://t.co/CI5p3RsXBu pic.twitter.com/2yMIk966QA— James Throt MBBS, MD, PhD, FRCPath (@JamesThrot) February 14, 2025

“Covid 19 is causing widespread brain damage on a global scale.

SARS-CoV-2 damages the brain. FACT.

Brain fog, memory issues, more mistakes/crashes/accidents, less empathy, worsening mental health/emotional regulation.

The signs are clear.

Signed, a neurologist

🧵”

·x.com·
Correct ✅ Covid 19 is causing widespread brain damage on a global scale. SARS-CoV-2 damages the brain. FACT. Brain fog, memory issues, more mistakes/crashes/accidents, less empathy, worsening mental health/emotional regulation. The signs are clear. Signed, a neurologist 🧵 https://t.co/CI5p3RsXBu pic.twitter.com/2yMIk966QA— James Throt MBBS, MD, PhD, FRCPath (@JamesThrot) February 14, 2025
SARS-CoV-2 infection of the brain: the K18-hACE2 mouse model to illustrate the role and response of the vasculature in neurotropic viral infection
SARS-CoV-2 infection of the brain: the K18-hACE2 mouse model to illustrate the role and response of the vasculature in neurotropic viral infection

Researchers used mouse model to study how SARS-CoV-2 infects the brain.

The virus targets neurons but spares blood vessels, triggering neuroinflammation and blood-brain barrier dysfunction.

·biorxiv.org·
SARS-CoV-2 infection of the brain: the K18-hACE2 mouse model to illustrate the role and response of the vasculature in neurotropic viral infection
Vaccination Does Not Impact Long COVID Neurological Symptoms
Vaccination Does Not Impact Long COVID Neurological Symptoms
“Vaccination prior to COVID-19 infection does not significantly affect neurological symptoms in patients with postacute sequelae of SARS-CoV-2 infection, according to a study published online Jan. 7 in Brain Communications”
Vaccination prior to COVID-19 infection does not significantly affect neurological symptoms in patients with postacute sequelae of SARS-CoV-2 infection, according to a study published online Jan. 7 in Brain Communications.Shreya Mukherjee, from the Northwestern University Feinb
·healthday.com·
Vaccination Does Not Impact Long COVID Neurological Symptoms
Neurological syndromes associated with COVID-19: a multicenter study in Brazil - BMC Infectious Diseases
Neurological syndromes associated with COVID-19: a multicenter study in Brazil - BMC Infectious Diseases
“197 patients were included, presenting with vascular syndromes (81), encephalopathy (68), encephalitis (19), Guillain-Barré syndrome (13), other neuropathies (12), and myelitis (4). The incidence curve of neurocovid mirrored that of COVID-19. Neurological syndromes were present regardless of COVID-19 severity. The median time from COVID-19 to onset of neurological symptoms was 14 days, suggesting a post-infectious immune-mediated mechanism.”
·flip.it·
Neurological syndromes associated with COVID-19: a multicenter study in Brazil - BMC Infectious Diseases
Neurologic Manifestations of Long COVID Disproportionately Affect Young and Middle‐Age Adults
Neurologic Manifestations of Long COVID Disproportionately Affect Young and Middle‐Age Adults
“Neurologic Manifestations of Long COVID Disproportionately Affect Young and Middle-Age Adults”
Neurologic Manifestations of Long COVID Disproportionately Affect Young and Middle-Age Adults
·onlinelibrary.wiley.com·
Neurologic Manifestations of Long COVID Disproportionately Affect Young and Middle‐Age Adults