Neuroimmune Dysfunction Facilitates COVID-19-Associated Neurological C
A review of the neurological manifestations of SARS-CoV-2 infection and long-term effects
SARS-CoV-2 and HSV-1 Induce Amyloid Aggregation in Human CSF Resulting in Drastic Soluble Protein Depletion
SARS-CoV-2 and HSV-1 induce amyloid aggregation, depleting soluble proteins.
Suggests a link between viral infections and neurodegenerative diseases via protein loss.
Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19
Evidence that a COVID-19 infection can induce neurological sequelae.
The SARSCoV2 spike protein can persist in the brain—skull bone marrow and meninges—to induce neurologic damage
SARS-CoV-2 spike protein accumulates & persists in the body for years after infection, especially in the skull-meninges-brain axis, potentially driving long COVID. mRNA vaccines help but cannot stop it.
In mice, it caused inflammation, anxiety, and worsened brain injuries. Vaccines reduced but did not fully eliminate it.
Cross-Section of Neurological Manifestations Among SARS-CoV-2 Omicron Subvariants—Single-Center Study
“The Omicron variant of SARS-CoV-2 presents a wide spectrum of neurological manifestations."
"Although there is an improvement in the survival rate of patients with COVID-19, the frequency of neurological manifestations increases."
"The occurrence of delirium, cerebrovascular diseases, and ischemic stroke results in higher mortality."
Brain-wide alterations revealed by spatial transcriptomics and proteomics in COVID-19 infection
“We identified dysregulation of mitochondrial and synaptic pathways in deep-layer excitatory neurons and upregulation of neuroinflammation in glia, consistent across both mRNA and protein. Remarkably, these alterations overlapped substantially with changes in age-related neurodegenerative diseases, including Parkinson’s disease and Alzheimer’s disease”
We identified dysregulation of mitochondrial and synaptic pathways in deep-layer excitatory neurons and upregulation of neuroinflammation in glia, consistent across both mRNA and protein. Remarkably, these alterations overlapped substantially with changes in age-related neurodegenerative diseases, including Parkinson’s disease and Alzheimer’s disease
If you’re not noticing the (obvious) cognitive impairment in practically everyone around you, it may be due to your own cognitive decline.
“If you’re not noticing the (obvious) cognitive impairment in practically everyone around you, it may be due to your own cognitive decline.
Or denial is rearing its ugly head once again.
Perhaps it’s easier for me considering my background, but honestly, it’s so bloody palpable.”
SARS-CoV-2 Invasion and Pathological Links to Prion Disease
Nearly half of those infected with SARS-CoV-2 experience long-term neurological problems, including brain fog and memory issues.
An infection may accelerate or exacerbate prion diseases like Creutzfeldt–Jakob disease, leading to rapid neurodegeneration.
Cognitive profile following COVID-19 infection: Clinical predictors leading to neuropsychological impairment
Covid itself causes cognitive impairment. From 2020, prior to Covid vaccination of any kind:
“In our cohort of COVID-19 patients neurologic manifestations were frequent, including cognitive impairment.”
Driving Under the Cognitive Influence of COVID-19: Exploring the Impact of Acute SARS-CoV-2 Infection on Road Safety | Neurology
"The study suggests that acute COVID-19, regardless of Long COVID status, is linked to an increased risk of car crashes presumably due to neurologic changes caused by SARS-CoV-2."
Neurological complications caused by SARS-CoV-2
Very comprehensive evaluation of known neurological damage from SarsCov2:
“The pathogenesis of neurological disorders caused by SARS-CoV-2 involves several mechanisms. First, SARS-CoV-2 could enter the brain through retrograde transmission & hematogenous routes & disrupt brain function & structure, thus causing or exacerbating neurological disorders…”
Part 1 of 2
Part 1 of 2 Lead exposure as a child is safer than repeat COVID infections for brain health LaughterinLight PhD is a biomedical researcher, immunologist