COVID & the BRAIN… a thread 🧵
Cognitive deficits after COVID-19 associated with brain injury biomarkers and volume loss
“Cognitive deficits after COVID-19 associated with brain injury biomarkers and volume loss”
Cross-Section of Neurological Manifestations Among SARS-CoV-2 Omicron Subvariants—Single-Center Study
“The Omicron variant of SARS-CoV-2 presents a wide spectrum of neurological manifestations."
"Although there is an improvement in the survival rate of patients with COVID-19, the frequency of neurological manifestations increases."
"The occurrence of delirium, cerebrovascular diseases, and ischemic stroke results in higher mortality."
Part 2 of 2
Part 1 of 2
Why people can no longer drive.
Brain-wide alterations revealed by spatial transcriptomics and proteomics in COVID-19 infection
“We identified dysregulation of mitochondrial and synaptic pathways in deep-layer excitatory neurons and upregulation of neuroinflammation in glia, consistent across both mRNA and protein. Remarkably, these alterations overlapped substantially with changes in age-related neurodegenerative diseases, including Parkinson’s disease and Alzheimer’s disease”
We identified dysregulation of mitochondrial and synaptic pathways in deep-layer excitatory neurons and upregulation of neuroinflammation in glia, consistent across both mRNA and protein. Remarkably, these alterations overlapped substantially with changes in age-related neurodegenerative diseases, including Parkinson’s disease and Alzheimer’s disease
Cognition and Memory after Covid-19 in a Large Community Sample | NEJM
Cognition and Memory after Covid-19 in a Large Community Sample
Cognition and Memory after Covid-19 in a Large Community Sample
Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction - PubMed
“Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction”
Posthospitalization
If you’re not noticing the (obvious) cognitive impairment in practically everyone around you, it may be due to your own cognitive decline.
“If you’re not noticing the (obvious) cognitive impairment in practically everyone around you, it may be due to your own cognitive decline.
Or denial is rearing its ugly head once again.
Perhaps it’s easier for me considering my background, but honestly, it’s so bloody palpable.”
Mounting research shows that COVID-19 leaves its mark on the brain, including significant drops in IQ scores : r/news
“Mounting research shows that COVID-19 leaves its mark on the brain, including significant drops in IQ scores"
Worse, most people don’t even notice it has happened to themselves.
“Worse, most people don’t even notice it has happened to themselves.
But I can tell you we who continue to mask and have many fewer COVID infections can see the growing cognitive damage in more and more people around us.
Memory problems, like recall and word finding delays. Weakness and fatigue and motor control impairment. Growing executive function and emotional regulation deficits.
More and more friends disables and forced out of work or school by Long COVID symptoms.
It’s scary to witness the broad societal decline, and dispiriting to see so many governments and Public Health agencies persist in minimizing the growing problem.”
Cognitive profile following COVID-19 infection: Clinical predictors leading to neuropsychological impairment
Covid itself causes cognitive impairment. From 2020, prior to Covid vaccination of any kind:
“In our cohort of COVID-19 patients neurologic manifestations were frequent, including cognitive impairment.”
COVID survivors may develop dementia
“COVID-19 survivors show signs of significant cognitive deficits which could become dementia even a year after having the virus.. The team [in India] found that more than 80% of people tested reported at least one of four symptoms – depression, anxiety, stress and insomnia – ranging from mild to severe.. At least 6.1% of the patients were diagnosed with mild cognitive impairment and 4% developed dementia. More than 60% of the patients experienced a loss of taste and smell during the active phase of the infection. This could alter the function of brain areas linked to cognitive ability and emotional well-being.."
COVID-19 survivors show signs of significant cognitive deficits which could become dementia even a year after having the virus1. They also have an increased risk of depression, anxiety and disrupted sleep.
How long COVID could lift the fog on neurocognitive disorders
‘I’m a shell of myself. My physical issues aren’t half as bad as my brain problems. You can say brain fog, but that doesn’t come close to doing it justice.’”
Driving Under the Cognitive Influence of COVID-19: Exploring the Impact of Acute SARS-CoV-2 Infection on Road Safety | Neurology
"The study suggests that acute COVID-19, regardless of Long COVID status, is linked to an increased risk of car crashes presumably due to neurologic changes caused by SARS-CoV-2."
A 43% increase since 2019.
A 43% increase cognitive disabilities since 2019.
“This is tragic and horrifying. And it’s going to get progressively worse as we’re all systematically reinfected.”
Whoopi Goldberg Commiserates With Fellow-Covid Sufferer Joe Biden: “Sometimes I Go For A Word And It’s Not There”
Whoopi Goldberg, who just had her 4th COVID infection, joked about her post infection brain damage on TV.
“I’m just getting over COVID – again – and I can barely remember anybody’s name. There are times when I go for a word and it’s not there.”
Emerging signs of Alzheimer‐like tau hyperphosphorylation and neuroinflammation in the brain post recovery from COVID‐19
Emerging signs of Alzheimer’s-like pathology in brains if people recovered from COVID-19, even though no direct SARS-CoV-2 invasion was detected
Study shows that COVID-19 causes cognitive decline among those without long COVID symptoms
“A new study in eClinicalMedicine has found that healthy volunteers infected with SARS-CoV-2 had measurably worse cognitive function for up to a year after infection when compared to uninfected controls. Significantly, infected controls did not report any symptoms related to these cognitive deficits, indicating that they were unaware of them.”
A new study in eClinicalMedicine has found that healthy volunteers infected with SARS-CoV-2 had measurably worse cognitive function for up to a year after infection when compared to uninfected controls. Significantly, infected controls did not report any symptoms related to these cognitive deficits, indicating that they were unaware of them. The net effect is that potentially billions of people worldwide with a his
Changes in memory and cognition during the SARS-CoV-2 human challenge study
“Patient-reported outcomes and cross-sectional evidence show an association between COVID-19 and persistent cognitive problems.”
Frontiers | Unravelling the connection between COVID-19 and Alzheimer’s disease: a comprehensive review
“Unravelling the connection between COVID-19 and Alzheimer’s disease: a comprehensive review”
Neurological complications caused by SARS-CoV-2
Very comprehensive evaluation of known neurological damage from SarsCov2:
“The pathogenesis of neurological disorders caused by SARS-CoV-2 involves several mechanisms. First, SARS-CoV-2 could enter the brain through retrograde transmission & hematogenous routes & disrupt brain function & structure, thus causing or exacerbating neurological disorders…”
One infection in ‘22, took Paxlovid. Still got TBI. Not recovered. Was ultra marathon runner, cyclist, executive. Fit, active. Everyone is at risk of poor outcome, even infants. Thanks for raising awareness.
“One infection in ‘22, took Paxlovid. Still got TBI. Not recovered. Was ultra marathon runner, cyclist, executive. Fit, active. Everyone is at risk of poor outcome, even infants.”
Does Covid Lead to Dementia? Here's What the Virus May Have Done to Y…
Non paywall version of catalogued Bloomberg article
Scientists are worried that persisting cognitive issues may signal a coming surge of dementia and other mental conditions
What We Know About Covid’s Impact on Your Brain
“Scientists are worried that persisting cognitive issues may signal a coming surge of dementia and other mental conditions”
COVID's Inflammation Linked to Long-Term Brain Effects - Neuroscience News
“A significant portion of COVID-19 survivors, even those who had mild cases, may experience cognitive decline and difficulty concentrating for extended periods after the infection.”