Understanding the Impact of COVID-19 on Personality and Brain Function: A Grim Reality or a Wake-Up Call?
“A nightmare scenario would be if mankind were targeted by a pathogen that attacks our frontal lobes and changes our personalities. Such a pathogen could bring an end to society as we know it. Unfortunately, the nightmare may be real and taking shape in SARS-CoV-2.”
We are currently watching what I can only describe as the early stages of Frontotemporal Dementia on a mass scale playing out in real time. The geopolitical ramifications of this are worrisome. I am in no doubt about what I’m seeing. The cause? Ceaseless SARS-CoV-2 infections pic.twitter.com/0X96poRxHJ— James Throt MBBS, MD, PhD, FRCPath (@JamesThrot) March 1, 2025
“We are currently watching what I can only describe as the early stages of Frontotemporal Dementia on a mass scale playing out in real time.
The geopolitical ramifications of this are worrisome.
I am in no doubt about what I’m seeing.
The cause?
Ceaseless SARS-CoV-2 infections” A THREAD WITH STUDIES:
Correct ✅ Covid 19 is causing widespread brain damage on a global scale. SARS-CoV-2 damages the brain. FACT. Brain fog, memory issues, more mistakes/crashes/accidents, less empathy, worsening mental health/emotional regulation. The signs are clear. Signed, a neurologist 🧵 https://t.co/CI5p3RsXBu pic.twitter.com/2yMIk966QA— James Throt MBBS, MD, PhD, FRCPath (@JamesThrot) February 14, 2025
“Covid 19 is causing widespread brain damage on a global scale.
SARS-CoV-2 damages the brain. FACT.
Brain fog, memory issues, more mistakes/crashes/accidents, less empathy, worsening mental health/emotional regulation.
The signs are clear.
Signed, a neurologist
🧵”
New neuroscience research shows COVID-19 leaves mark on young adult brains
“A new study published in Brain, Behavior, and Immunity has found that young adults who have recovered from COVID-19 show distinct patterns of brain activity during cognitive tasks, even if they perform normally on those tasks. These brain activity changes are similar to those seen in much older adults and are particularly pronounced in individuals reporting ‘brain fog.’”
A new study published in Brain, Behavior, and Immunity has found that young adults who have recovered from COVID-19 show distinct patterns of brain activity during cognitive tasks, even if they perform normally on those tasks. These brain activity changes are similar to those seen in much older adults and are particularly pronounced in individuals reporting “brain fog.”
I’ve spoken about this numerous times since Covid ate brain, but I’m now missing The Gift of Fear. Prior to my dramatic personality/cognitive changes, I had a highly evolved internal warning system that successfully kept me alive. Now I don’t care. It *could* be connected to…
“I’ve spoken about this numerous times since Covid ate brain, but I’m now missing The Gift of Fear. Prior to my dramatic personality/cognitive changes, I had a highly evolved internal warning system that successfully kept me alive. Now I don’t care. It could be connected to knowing nothing is going to be done since our country was hijacked by the 0.1% & deliberately broken long, long ago, & we all know everyone is going to reflexively blame The Other Side while Both Sides work together to fuck us over brunch. Why worry about things we’re going to pretend away?”
Does COVID increase the risk of Alzheimer’s disease?
“Scientists discover that even mild COVID-19 can alter brain proteins linked to Alzheimer’s disease, potentially increasing dementia risk—raising urgent public health concerns.”
Scientists discover that even mild COVID-19 can alter brain proteins linked to Alzheimer’s disease, potentially increasing dementia risk—raising urgent public health concerns.
"The impact I am seeing on my clients post-COVID is something I hadn’t seen previously in the years I have worked in this field. The cognitive decline post-COVID infection is immense, thus confirming the impact this virus has on the brain..."
"The impact I am seeing on my clients post-COVID is something I hadn’t seen previously in the years I have worked in this field. The cognitive decline post-COVID infection is immense, thus confirming the impact this virus has on the brain..."
"Widespread use of metal caused estimated 2- to 3-point drop in IQ for nearly 180 years of Pax Romana"
"Widespread use of metal caused estimated 2- to 3-point drop in IQ for nearly 180 years of Pax Romana"
Meanwhile, #Covid in 5 years: "Participants with persistent symptoms had a 6-point loss in IQ, while those who had been admitted to an ICU experienced a 9-point loss in IQ."
COVID-19 may Enduringly Impact cognitive performance and brain haemodynamics in undergraduate students
“COVID-19 may Enduringly Impact cognitive performance and brain haemodynamics in undergraduate students”
“37 % of the undergraduates exhibited impaired cognition up to 17 months post-infection.”
SARS-CoV-2 infection in microglia and its sequelae: What do we know so far?
“SARS-CoV-2 may infect CNS, affecting microglia and brain cells. • Neuroinflammation from SARS-CoV-2 could lead to long COVID memory issues.”
SARS-CoV-2 may infect CNS, affecting microglia and brain cells.•Neuroinflammation from SARS-CoV-2 could lead to long COVID memory issues.
Long COVID: SARS-CoV-2 spike protein accumulation linked to long-lasting brain effects
“The study shows that the SARS-CoV-2 spike protein remains in the brain's protective layers, the meninges, and the skull's bone marrow for up to four years after infection. This persistent presence of the spike protein could trigger chronic inflammation in affected individuals and increase the risk of neurodegenerative diseases.”
The study shows that the SARS-CoV-2 spike protein remains in the brain's protective layers, the meninges, and the skull's bone marrow for up to four years after infection. This persistent presence of the spike protein could trigger chronic inflammation in affected individuals and increase the risk of neurodegenerative diseases.
Cognitive deficits after COVID-19 associated with brain injury biomarkers and volume loss
“Cognitive deficits after COVID-19 associated with brain injury biomarkers and volume loss”
The study found that patients hospitalized with COVID-19, both with and without acute neurological complications, had worse cognitive scores than expected for their age, sex, and education level. These cognitive deficits were observed across all cognitive domains tested. The cognitive impairment was associated with increased levels of brain injury biomarkers in the blood and reduced volume of a specific brain region (the anterior cingulate cortex) on MRI scans. Factors like the severity of the initial COVID-19 illness and the presence of acute confusion (encephalopathy) were linked to the worst cognitive scores.
Cognitive deficits after COVID-19 associated with brain injury biomarkers and volume loss
Cross-Section of Neurological Manifestations Among SARS-CoV-2 Omicron Subvariants—Single-Center Study
“The Omicron variant of SARS-CoV-2 presents a wide spectrum of neurological manifestations."
"Although there is an improvement in the survival rate of patients with COVID-19, the frequency of neurological manifestations increases."
"The occurrence of delirium, cerebrovascular diseases, and ischemic stroke results in higher mortality."
Brain-wide alterations revealed by spatial transcriptomics and proteomics in COVID-19 infection
“We identified dysregulation of mitochondrial and synaptic pathways in deep-layer excitatory neurons and upregulation of neuroinflammation in glia, consistent across both mRNA and protein. Remarkably, these alterations overlapped substantially with changes in age-related neurodegenerative diseases, including Parkinson’s disease and Alzheimer’s disease”
We identified dysregulation of mitochondrial and synaptic pathways in deep-layer excitatory neurons and upregulation of neuroinflammation in glia, consistent across both mRNA and protein. Remarkably, these alterations overlapped substantially with changes in age-related neurodegenerative diseases, including Parkinson’s disease and Alzheimer’s disease
Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction - PubMed
“Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction”
Posthospitalization