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Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19
Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19

Evidence that a COVID-19 infection can induce neurological sequelae.

The SARSCoV2 spike protein can persist in the brain—skull bone marrow and meninges—to induce neurologic damage

SARS-CoV-2 spike protein accumulates & persists in the body for years after infection, especially in the skull-meninges-brain axis, potentially driving long COVID. mRNA vaccines help but cannot stop it.

In mice, it caused inflammation, anxiety, and worsened brain injuries. Vaccines reduced but did not fully eliminate it.

·cell.com·
Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19
Cross-Section of Neurological Manifestations Among SARS-CoV-2 Omicron Subvariants—Single-Center Study
Cross-Section of Neurological Manifestations Among SARS-CoV-2 Omicron Subvariants—Single-Center Study

“The Omicron variant of SARS-CoV-2 presents a wide spectrum of neurological manifestations."

"Although there is an improvement in the survival rate of patients with COVID-19, the frequency of neurological manifestations increases."

"The occurrence of delirium, cerebrovascular diseases, and ischemic stroke results in higher mortality."

·mdpi.com·
Cross-Section of Neurological Manifestations Among SARS-CoV-2 Omicron Subvariants—Single-Center Study
Brain-wide alterations revealed by spatial transcriptomics and proteomics in COVID-19 infection
Brain-wide alterations revealed by spatial transcriptomics and proteomics in COVID-19 infection
“We identified dysregulation of mitochondrial and synaptic pathways in deep-layer excitatory neurons and upregulation of neuroinflammation in glia, consistent across both mRNA and protein. Remarkably, these alterations overlapped substantially with changes in age-related neurodegenerative diseases, including Parkinson’s disease and Alzheimer’s disease”
We identified dysregulation of mitochondrial and synaptic pathways in deep-layer excitatory neurons and upregulation of neuroinflammation in glia, consistent across both mRNA and protein. Remarkably, these alterations overlapped substantially with changes in age-related neurodegenerative diseases, including Parkinson’s disease and Alzheimer’s disease
·nature.com·
Brain-wide alterations revealed by spatial transcriptomics and proteomics in COVID-19 infection
Recorded this video on the microscope yesterday. A single infected cell arrives on the brain inside a blood vessel. Don't underestimate how much neuroinflammation one infected cell can cause.
Recorded this video on the microscope yesterday. A single infected cell arrives on the brain inside a blood vessel. Don't underestimate how much neuroinflammation one infected cell can cause.

“Recorded this video on the microscope yesterday. A single #SARSCoV2 infected cell arrives on the brain inside a blood vessel. Don't underestimate how much neuroinflammation one infected cell can cause. Brain-vascular-immune interface is the future of neuroscience #NeuroCovid”

·x.com·
Recorded this video on the microscope yesterday. A single infected cell arrives on the brain inside a blood vessel. Don't underestimate how much neuroinflammation one infected cell can cause.
Neurological complications caused by SARS-CoV-2
Neurological complications caused by SARS-CoV-2

Very comprehensive evaluation of known neurological damage from SarsCov2:

“The pathogenesis of neurological disorders caused by SARS-CoV-2 involves several mechanisms. First, SARS-CoV-2 could enter the brain through retrograde transmission & hematogenous routes & disrupt brain function & structure, thus causing or exacerbating neurological disorders…”

·journals.asm.org·
Neurological complications caused by SARS-CoV-2
Does Covid Lead to Dementia? Here's What the Virus May Have Done to Y…
Does Covid Lead to Dementia? Here's What the Virus May Have Done to Y…
Non paywall version of catalogued Bloomberg article
Scientists are worried that persisting cognitive issues may signal a coming surge of dementia and other mental conditions
·archive.is·
Does Covid Lead to Dementia? Here's What the Virus May Have Done to Y…