What We Know About Covid’s Impact on Your Brain?
Brain shrinkage is observed even in mild or asymptomatic cases of Covid and impacts cognition.
COVID & the BRAIN… a thread 🧵
Long COVID: SARS-CoV-2 spike protein accumulation linked to long-lasting brain effects
“The study shows that the SARS-CoV-2 spike protein remains in the brain's protective layers, the meninges, and the skull's bone marrow for up to four years after infection. This persistent presence of the spike protein could trigger chronic inflammation in affected individuals and increase the risk of neurodegenerative diseases.”
The study shows that the SARS-CoV-2 spike protein remains in the brain's protective layers, the meninges, and the skull's bone marrow for up to four years after infection. This persistent presence of the spike protein could trigger chronic inflammation in affected individuals and increase the risk of neurodegenerative diseases.
Video showing accumulation of spike protein (red) in skull bone marrow from a patient who died from Covid
Video showing accumulation of spike protein (red) in skull bone marrow from a patient who died from Covid
Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19
Evidence that a COVID-19 infection can induce neurological sequelae.
The SARSCoV2 spike protein can persist in the brain—skull bone marrow and meninges—to induce neurologic damage
SARS-CoV-2 spike protein accumulates & persists in the body for years after infection, especially in the skull-meninges-brain axis, potentially driving long COVID. mRNA vaccines help but cannot stop it.
In mice, it caused inflammation, anxiety, and worsened brain injuries. Vaccines reduced but did not fully eliminate it.
Cross-Section of Neurological Manifestations Among SARS-CoV-2 Omicron Subvariants—Single-Center Study
“The Omicron variant of SARS-CoV-2 presents a wide spectrum of neurological manifestations."
"Although there is an improvement in the survival rate of patients with COVID-19, the frequency of neurological manifestations increases."
"The occurrence of delirium, cerebrovascular diseases, and ischemic stroke results in higher mortality."
From COVID to Cognition | Kentucky researchers find COVID-19 could lead to Alzheimer's
“From COVID to Cognition | Kentucky researchers find COVID-19 could lead to Alzheimer's”
From COVID to Cognition | Kentucky researchers find COVID-19 could lead to Alzheimer's
MRI scans reveal the damage long Covid does to your brain
“MRI scans reveal the damage long Covid does to your brain
Researchers suggested lasting Covid symptoms might be an indirect effect of brainstem inflammatory injury”
Does Covid Lead to Dementia? Here's What the Virus May Have Done to Y…
Non paywall version of catalogued Bloomberg article
Scientists are worried that persisting cognitive issues may signal a coming surge of dementia and other mental conditions
COVID's Inflammation Linked to Long-Term Brain Effects - Neuroscience News
“A significant portion of COVID-19 survivors, even those who had mild cases, may experience cognitive decline and difficulty concentrating for extended periods after the infection.”
Study uncovers the basis of COVID-19-related brain fog | University of Minnesota
EXTREME and incomplete oversimplification of the many complex neurological issues caused by SarsCov2, but important facet of the vaguely defined “brain fog” of Long Covid and post-acute Covid lingering symptoms.
“Neurological symptoms have been widely observed in COVID-19 patients, with many survivors exhibiting persistent neurological and cognitive impairment. New research from the University of Minnesota found that COVID-19 triggers inflammation in the brain, which is linked to many COVID-related symptoms such as fatigue and ‘brain fog.’”
New Series - Neuroinflammation, Pain, and Fatigue - YouTube
The most helpful educational series out there right now is Dr. Jarred Youngers video series on "Neuroinflammation, Pain, and Fatigue".
“The most helpful #MECFS #LongCovid educational series out there right now is Dr. Jarred Youngers video series on "Neuroinflammation, Pain, and Fatigue".
Start at the beginning or jump in as your interest is piqued. There are now 28 shortish videos (most under 15min) and this series will provide an incredible grounding in all things neuroinflammation.
Dr. Younger is all about the 'tools' and 'interventions' and patient education and has done more to educate us about available interventions for neuroinflammation than any other researcher.”
Wes Wilson on Twitter
Study from CAMH found, via PET scans, elevated levels of the protein TSPO, a brain marker of inflammation, in patients with onset of depression in long covid
more than 200 million globally may experience lingering neurological symptoms from COVID, including depression, memory impairment, slower motor control, low motivation and energy, for months to even years due to brain inflammation from long COVID
this along side everything we have learned in the last 2.5 years ( much summarized in the lit review done by Stanford and Yale, linked in the comments ) moves us a step closer in understanding the underlying biological mechanisms behind these symptoms
CAMH study confirms ongoing brain inflammation associated with long COVID
"What’s new about this study is that it shows that inflammation is hanging around for a long time in the brains of people with long COVID even after only mild to moderate symptoms of active COVID-19,”
'A silent killer': COVID-19 shown to trigger inflammation in the brain
Another study showing that metabolic pathways activated in brain by covid are similar to the ones that happen in Alzheimer & Parkinson diseases. While the drugs to stop this inflammation are being tested, the inflammation is affecting millions of ppl.
![Long COVID is associated with extensive in-vivo neuroinflammation on [18F]DPA-714 PET](https://rdl.ink/render/https%3A%2F%2Fwww.medrxiv.org%2Fsites%2Fdefault%2Ffiles%2Fimages%2Fmedrxiv_logo_homepage7-5-small-test-up.png?width=350&height=&ar=16:9&mode=crop&format=avif&dpr=2){kind=logo}
Long COVID is associated with extensive in-vivo neuroinflammation on [18F]DPA-714 PET
COVID-19: Long COVID Neuroinflammation shown in PET scan
A study shows positron emission tomography (PET) scan imaging of two Long COVID patients compared with controls (