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Brain-wide alterations revealed by spatial transcriptomics and proteomics in COVID-19 infection
Brain-wide alterations revealed by spatial transcriptomics and proteomics in COVID-19 infection
“We identified dysregulation of mitochondrial and synaptic pathways in deep-layer excitatory neurons and upregulation of neuroinflammation in glia, consistent across both mRNA and protein. Remarkably, these alterations overlapped substantially with changes in age-related neurodegenerative diseases, including Parkinson’s disease and Alzheimer’s disease”
We identified dysregulation of mitochondrial and synaptic pathways in deep-layer excitatory neurons and upregulation of neuroinflammation in glia, consistent across both mRNA and protein. Remarkably, these alterations overlapped substantially with changes in age-related neurodegenerative diseases, including Parkinson’s disease and Alzheimer’s disease
#Brain#cognition#brain injury#Neuroinflammation#Post-Acute Conditions#neurological#Parkinsons#Alzheimers
·nature.com·
Brain-wide alterations revealed by spatial transcriptomics and proteomics in COVID-19 infection
Emerging signs of Alzheimer‐like tau hyperphosphorylation and neuroinflammation in the brain post recovery from COVID‐19
Emerging signs of Alzheimer‐like tau hyperphosphorylation and neuroinflammation in the brain post recovery from COVID‐19
Emerging signs of Alzheimer’s-like pathology in brains if people recovered from COVID-19, even though no direct SARS-CoV-2 invasion was detected
#Alzheimers#cognition#cognitive decline#memory#memory loss#long covid#Post-Acute Conditions#brain#brain injury
·onlinelibrary.wiley.com·
Emerging signs of Alzheimer‐like tau hyperphosphorylation and neuroinflammation in the brain post recovery from COVID‐19
Does Covid Lead to Dementia? Here's What the Virus May Have Done to Y…
Does Covid Lead to Dementia? Here's What the Virus May Have Done to Y…
Non paywall version of catalogued Bloomberg article
Scientists are worried that persisting cognitive issues may signal a coming surge of dementia and other mental conditions
#brain#brain injury#brain atrophy#dementia#Alzheimers#Memory#memory loss#brain fog#Post-Acute Conditions#long covid#fatigue#cognition#cognitive decline#Neuroinflammation#Immune system#immune dysregulation#T cells#Parkinsons#IQ
·archive.is·
Does Covid Lead to Dementia? Here's What the Virus May Have Done to Y…
Parallel electrophysiological abnormalities due to COVID‐19 infection and to Alzheimer's disease and related dementia
Parallel electrophysiological abnormalities due to COVID‐19 infection and to Alzheimer's disease and related dementia
“Resting-state EEG abnormalities include EEG slowing (reduced alpha rhythm; increased slow waves) and epileptiform activity. An expert panel conducted a systematic review to present compelling evidence that cognitive deficits due to COVID-19 and to Alzheimer's disease and related dementia (ADRD) are driven by overlapping pathologies and neurophysiological abnormalities. EEG abnormalities seen in COVID-19 patients resemble those observed in early stages of neurodegenerative diseases, particularly ADRD”
#Alzheimers#dementia#cognition#brain injury#Memory#memory loss
·alz-journals.onlinelibrary.wiley.com·
Parallel electrophysiological abnormalities due to COVID‐19 infection and to Alzheimer's disease and related dementia