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SARS-CoV-2 and HSV-1 Induce Amyloid Aggregation in Human CSF Resulting in Drastic Soluble Protein Depletion
SARS-CoV-2 and HSV-1 Induce Amyloid Aggregation in Human CSF Resulting in Drastic Soluble Protein Depletion

SARS-CoV-2 and HSV-1 induce amyloid aggregation, depleting soluble proteins.

Suggests a link between viral infections and neurodegenerative diseases via protein loss.

#Brain#Post-Acute Conditions#Amyloid#neurodegeneration#Neurodegenerative#Alzheimers#neurologic changes#neurological#amyloid aggregation
·pubs.acs.org·
SARS-CoV-2 and HSV-1 Induce Amyloid Aggregation in Human CSF Resulting in Drastic Soluble Protein Depletion
Frontiers | Frequency of Neurological Diseases After COVID-19, Influenza A/B and Bacterial Pneumonia
Frontiers | Frequency of Neurological Diseases After COVID-19, Influenza A/B and Bacterial Pneumonia
A study of electronic medical records of 35,362 COVID-19 outpatients in Denmark showed an increased relative risk (RR) of 3.5 for Alzheimer's disease and 2.6 for Parkinson's disease compared to outpatients who did not have COVID-19.
#Alzheimers#Parkinsons#risks#Brain#Post-Acute Conditions
·frontiersin.org·
Frontiers | Frequency of Neurological Diseases After COVID-19, Influenza A/B and Bacterial Pneumonia
Brain-wide alterations revealed by spatial transcriptomics and proteomics in COVID-19 infection
Brain-wide alterations revealed by spatial transcriptomics and proteomics in COVID-19 infection
“We identified dysregulation of mitochondrial and synaptic pathways in deep-layer excitatory neurons and upregulation of neuroinflammation in glia, consistent across both mRNA and protein. Remarkably, these alterations overlapped substantially with changes in age-related neurodegenerative diseases, including Parkinson’s disease and Alzheimer’s disease”
We identified dysregulation of mitochondrial and synaptic pathways in deep-layer excitatory neurons and upregulation of neuroinflammation in glia, consistent across both mRNA and protein. Remarkably, these alterations overlapped substantially with changes in age-related neurodegenerative diseases, including Parkinson’s disease and Alzheimer’s disease
#Brain#cognition#brain injury#Neuroinflammation#Post-Acute Conditions#neurological#Parkinsons#Alzheimers
·nature.com·
Brain-wide alterations revealed by spatial transcriptomics and proteomics in COVID-19 infection
Emerging signs of Alzheimer‐like tau hyperphosphorylation and neuroinflammation in the brain post recovery from COVID‐19
Emerging signs of Alzheimer‐like tau hyperphosphorylation and neuroinflammation in the brain post recovery from COVID‐19
Emerging signs of Alzheimer’s-like pathology in brains if people recovered from COVID-19, even though no direct SARS-CoV-2 invasion was detected
#Alzheimers#cognition#cognitive decline#memory#memory loss#long covid#Post-Acute Conditions#brain#brain injury
·onlinelibrary.wiley.com·
Emerging signs of Alzheimer‐like tau hyperphosphorylation and neuroinflammation in the brain post recovery from COVID‐19
Kentucky research links long COVID brain fog to Alzheimer’s | Lexingt…
Kentucky research links long COVID brain fog to Alzheimer’s | Lexingt…
“Some patients with COVID see similar brain changes to people with such neurodegenerative disorders as Alzheimer’s, according to University of Kentucky researchers.”
Some patients with COVID see similar brain changes to people with such neurodegenerative disorders as Alzheimer’s, according to University of Kentucky researchers.
#Alzheimers#brain#brain injury#Memory#memory loss#Post-Acute Conditions
·archive.is·
Kentucky research links long COVID brain fog to Alzheimer’s | Lexingt…
Does Covid Lead to Dementia? Here's What the Virus May Have Done to Y…
Does Covid Lead to Dementia? Here's What the Virus May Have Done to Y…
Non paywall version of catalogued Bloomberg article
Scientists are worried that persisting cognitive issues may signal a coming surge of dementia and other mental conditions
#brain#brain injury#brain atrophy#dementia#Alzheimers#Memory#memory loss#brain fog#Post-Acute Conditions#long covid#fatigue#cognition#cognitive decline#Neuroinflammation#Immune system#immune dysregulation#T cells#Parkinsons#IQ
·archive.is·
Does Covid Lead to Dementia? Here's What the Virus May Have Done to Y…
UK researchers find Alzheimer’s-like brain changes in long COVID patients
UK researchers find Alzheimer’s-like brain changes in long COVID patients
“New research from the University of Kentucky’s Sanders-Brown Center on Aging shows compelling evidence that the cognitive impairments observed in long COVID patients share striking similarities with those seen in Alzheimer’s disease and related dementias.”
#dementia#Alzheimers#long covid#brain#brain injury#Post-Acute Conditions#Memory#memory loss
·uknow.uky.edu·
UK researchers find Alzheimer’s-like brain changes in long COVID patients
Does Long COVID Lead to Alzheimer's? A New Study Took an Unexpected Turn
Does Long COVID Lead to Alzheimer's? A New Study Took an Unexpected Turn
“More than one in ten people who catch COVID don’t fully recover — developing a chronic condition called Long COVID which causes a variety of debilitating symptoms, including brain fog. Since some studies have found that COVID infections are associated with overall brain shrinkage, altered brain structure, and an increased risk of developing Alzheimer’s, researchers have been investigating the links between COVID and Alzheimer’s.”
More than one in ten people who catch COVID don’t fully recover — developing a chronic condition called Long COVID which causes a variety of debilitating symptoms, including brain fog. Since some studies have found that COVID infections are associated with overall brain shrinkage, altered brain structure, and an increased risk of developing Alzheimer’s, researchers have been investigating the links between COVID and Alzheimer’s.
#Alzheimers#brain#brain injury#dementia#long covid#Post-Acute Conditions
·beingpatient.com·
Does Long COVID Lead to Alzheimer's? A New Study Took an Unexpected Turn
Severe acute respiratory syndrome coronavirus 2 infection leads to Tau pathological signature in neurons
Severe acute respiratory syndrome coronavirus 2 infection leads to Tau pathological signature in neurons
“It is now evident that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection results in a wide range of long-term neurological symptoms and is worryingly associated with the aggravation of Alzheimer’s disease. Little is known about the molecular basis of these manifestations.”
#brain#Alzheimers#Tau signature
·academic.oup.com·
Severe acute respiratory syndrome coronavirus 2 infection leads to Tau pathological signature in neurons
Risk for Developing Alzheimer’s Disease Increases by 50-80% In Older Adults Who Caught COVID-19 - Neuroscience News
Risk for Developing Alzheimer’s Disease Increases by 50-80% In Older Adults Who Caught COVID-19 - Neuroscience News
"Older people who were infected with COVID-19 show a substantially higher risk—as much as 50% to 80% higher than a control group—of developing Alzheimer’s disease within a year, according to a study of more than 6 million patients 65 and older."
#Brain#Alzheimers
·neurosciencenews.com·
Risk for Developing Alzheimer’s Disease Increases by 50-80% In Older Adults Who Caught COVID-19 - Neuroscience News
COVID-19 and neurodegenerative diseases
COVID-19 and neurodegenerative diseases
"many patients with COVID-19 experience a variety of neurological complications...possible mechanisms between COVID-19 and several typical neurodegenerative diseases, particularly Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis"
#Brain#Alzheimers#Parkinsons#ALS
·europeanreview.org·
COVID-19 and neurodegenerative diseases