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SARS-CoV-2 and HSV-1 Induce Amyloid Aggregation in Human CSF Resulting in Drastic Soluble Protein Depletion
SARS-CoV-2 and HSV-1 Induce Amyloid Aggregation in Human CSF Resulting in Drastic Soluble Protein Depletion

SARS-CoV-2 and HSV-1 induce amyloid aggregation, depleting soluble proteins.

Suggests a link between viral infections and neurodegenerative diseases via protein loss.

#Brain#Post-Acute Conditions#Amyloid#neurodegeneration#Neurodegenerative#Alzheimers#neurologic changes#neurological#amyloid aggregation
·pubs.acs.org·
SARS-CoV-2 and HSV-1 Induce Amyloid Aggregation in Human CSF Resulting in Drastic Soluble Protein Depletion
Brain-wide alterations revealed by spatial transcriptomics and proteomics in COVID-19 infection
Brain-wide alterations revealed by spatial transcriptomics and proteomics in COVID-19 infection
“We identified dysregulation of mitochondrial and synaptic pathways in deep-layer excitatory neurons and upregulation of neuroinflammation in glia, consistent across both mRNA and protein. Remarkably, these alterations overlapped substantially with changes in age-related neurodegenerative diseases, including Parkinson’s disease and Alzheimer’s disease”
We identified dysregulation of mitochondrial and synaptic pathways in deep-layer excitatory neurons and upregulation of neuroinflammation in glia, consistent across both mRNA and protein. Remarkably, these alterations overlapped substantially with changes in age-related neurodegenerative diseases, including Parkinson’s disease and Alzheimer’s disease
#Brain#cognition#brain injury#Neuroinflammation#Post-Acute Conditions#neurological#Parkinsons#Alzheimers
·nature.com·
Brain-wide alterations revealed by spatial transcriptomics and proteomics in COVID-19 infection