How does a transient viral infection like COVID lead to long lasting neurologic symptoms?
In humans and in animal models, SARS-CoV-2 can damage peripheral sensory nerves in the nose, leaving behind debris that can then trigger inflammation in brain microglia for weeks to months after infection, which can then lead to post-viral neurological symptoms like cognitive dysfunction (brain fog).
The peripheral neuron-to-microglia axis offers a potential explanation for persistent inflammation seen in conditions like Long COVID and ME/CFS.
“Let’s talk about COVID, brain damage & society.
Specifically, what happens when a neurotropic virus repeatedly infects the population, targeting the frontal lobe & almost nobody talks about the consequences?
This thread is for the skeptics.
I’m a neurologist, stay with me 🧵”
“significant memory and executive function decline lasting up to a year, despite no reported subjective symptoms, prompting new questions about the virus’s long-term cognitive effects.”
“Long COVID can injure the brain - and persistent autoimmunity could be a major driver. A study links persistent AT1 receptor autoantibodies (AT1-AA) with neuroaxonal injury and cognitive symptoms. Here’s what it means🧵”
“COVID-19 survivors were at higher adjusted risk of mortality, major adverse cardiovascular events, fatigue, sleep disturbance, and dyspnea. • COVID-19 may be a risk factor for onset of symptoms and adverse events in patients with neurological conditions”
“Dad, 41, Diagnosed with Alzheimer's: 'You Feel Guilty That You're Doing That to the Kids' Fraser is sharing his symptoms — and what he’s learned about the disease — on his YouTube channel”
Exploring the Persistence of the Spike Protein along the Skull-Meninges-Brain Axis and the Neurological Effects of COVID-19
This analysis is supported by numerous videos and illustrations.
“Covid 19 is causing widespread brain damage on a global scale.
SARS-CoV-2 damages the brain. FACT.
Brain fog, memory issues, more mistakes/crashes/accidents, less empathy, worsening mental health/emotional regulation.
The signs are clear.
Signed, a neurologist
🧵”
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