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SARS-CoV-2 infection of the brain: the K18-hACE2 mouse model to illustrate the role and response of the vasculature in neurotropic viral infection
SARS-CoV-2 infection of the brain: the K18-hACE2 mouse model to illustrate the role and response of the vasculature in neurotropic viral infection

Researchers used mouse model to study how SARS-CoV-2 infects the brain.

The virus targets neurons but spares blood vessels, triggering neuroinflammation and blood-brain barrier dysfunction.

#brain#Nerves#neurological#neurologic changes#blood brain barrier#endothelial inflammation#Neuroinflammation#neuroinvasion#vascular#blood brain barrier dysfunction
·biorxiv.org·
SARS-CoV-2 infection of the brain: the K18-hACE2 mouse model to illustrate the role and response of the vasculature in neurotropic viral infection
Neuroinvasion and anosmia are independent phenomena upon infection with SARS-CoV-2 and its variants
Neuroinvasion and anosmia are independent phenomena upon infection with SARS-CoV-2 and its variants

SARS2 can invade your brain.

All variants are neuroinvasive.

Neuroinvasion and anosmia are independent phenomena upon infection.

SARS2 can travel retrogradely and anterogradely along axons in neuron-epithelial networks.

#neuroinvasion#neurological#anosmia#Smell loss#brain#brain injury
·nature.com·
Neuroinvasion and anosmia are independent phenomena upon infection with SARS-CoV-2 and its variants