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SARS-CoV-2 infection in hiPSC-derived neurons is cathepsin-dependent and causes accumulation of HIF1alpha and phosphorylated tau
SARS-CoV-2 infection in hiPSC-derived neurons is cathepsin-dependent and causes accumulation of HIF1alpha and phosphorylated tau

SARS-CoV-2 infects neurons using cathepsins, causing tau changes linked to Alzheimer’s and neuron death within days

This suggests neurodegenerative risks and potential for cathepsin inhibitors as treatment

#neurons#cathepsins#Brain#brain injury
·biorxiv.org·
SARS-CoV-2 infection in hiPSC-derived neurons is cathepsin-dependent and causes accumulation of HIF1alpha and phosphorylated tau