Mounting research shows that COVID-19 leaves its mark on the brain, including significant drops in IQ scores : r/news
“Mounting research shows that COVID-19 leaves its mark on the brain, including significant drops in IQ scores"
COVID and the brain: researchers zero in on how damage occurs
SARS-CoV-2 preferentially infects astrocytes, which support neuron function, potentially leading to symptoms like fatigue and confusion.
SARS-CoV-2 can also infect pericytes, leading to restricted blood flow and small-vessel strokes.
Recorded this video on the microscope yesterday. A single infected cell arrives on the brain inside a blood vessel. Don't underestimate how much neuroinflammation one infected cell can cause.
“Recorded this video on the microscope yesterday. A single #SARSCoV2 infected cell arrives on the brain inside a blood vessel. Don't underestimate how much neuroinflammation one infected cell can cause. Brain-vascular-immune interface is the future of neuroscience #NeuroCovid”
Pioneering discovery and therapeutics at the brain-vascular-immune interface
A new paper in Cell, “Pioneering discovery and therapeutics at the brain-vascular-immune interface,” describes COVID-19 as a neurological disease alongside multiple sclerosis, Alzheimer’s, stroke and traumatic brain injury.
“COVID-19 can accelerate progression of dementia and induce BBB disruption and inflammatory blood clots causally linked with neuroinflammation and neuronal loss.8 In neurodevelopmental disorders, prematurity and perinatal hypoxia that trigger brain hemorrhage and BBB disruption are risk factors for cerebral palsy, intellectual disability, and autism. Collectively, these risk factors highlight the interconnected vascular and immune triggers of neurological diseases.”
Fibrin drives thromboinflammation and neuropathology in COVID-19
Just published @Nature How fibrin drives brain inflammation in acute and #LongCovid and that a monoclonal antibody to fibrin protects against microglial activation
Cerebral blood flow alterations and host genetic association in individuals with long COVID: A transcriptomic-neuroimaging study - Yao Wang, Ziwei Yang, Xiumei Zheng, Xiao Liang, Lin Wu, Chengsi Wu, Jiankun Dai, Yuan Cao, Meng Li, Fuqing Zhou, 2024
Cerebral blood flow alterations & host genetic association with long COVID: A transcriptomic-neuroimaging study
Study: COVID-19 Can Accelerate Brain Aging, Lead to Irreversible Neurological Conditions
“Tiny leakages of blood in crucial brain regions of patients infected with Covid-19 can accelerate brain aging and lead to irreversible neurodegenerative conditions, according to a Houston Methodist review study.”
Cerebral hypoperfusion in post-COVID-19 cognitively impaired subjects revealed by arterial spin labeling MRI
New paper comparing #LongCovid patients to matched controls found significantly reduced blood flow all over the brain - frontal, temporal, & parietal lobes.
Middle column in the picture below are healthy controls; red/warm colors = more blood flow. 1/
Cerebral hypoperfusion in post-COVID-19 cognitively impaired subjects revealed by arterial spin labeling MRI
Study examining patients at a long COVID neurology clinic showing deficits in executive, attention, language and memory functions. MRIs showed reduced blood flow to frontal, parietal and temporal regions of the brain compared to age & sex matched controls
COVID Is Doing Something to Our Sleep, And Even to Our Dreams
"COVID can have a direct impact on the brain, including the areas that control both wake and sleep states...possible mechanisms could include the virus infecting the central nervous system or affecting the brain's blood supply."
Neurovascular Injury Evident in Sudden Death of Patients With COVID-19
"Neurovascular injury during COVID-19 infection is likely triggered by antibody-mediated cytotoxicity directed at endothelial cells."
Small NIH study reveals how immune response triggered by COVID-19 may
"scientists found evidence that antibodies—proteins produced by the immune system in response to viruses and other invaders--are involved in an attack on the cells lining the brain’s blood vessels..." Cross-referenced in thread on Covid & immune system
Neurovascular injury with complement activation and inflammation in COVID-19
The microvascular injury and inflammation of the brain, with immune complex formation, that can occur from Covid, from in-depth assessment of 9 patient autopsies and controls.
COVID Brain Problems May Stem From Attack on Endothelial Cells
"COVID Brain Problems May Stem From Attack on Endothelial Cells — Findings could have implications for treating long COVID"
Neurovascular injury with complement activation and inflammation in COVID-19
"All patients had multifocal vascular damage as determined by leakage of serum proteins into the brain parenchyma. This was accompanied by widespread endothelial cell activation...microthrombi were found adherent to the endothelial cells..."
Selective visuoconstructional impairment following mild COVID-19 with inflammatory and neuroimaging correlation findings
"investigate adults at least four months after recovering from mild COVID-19...In approximately 1/4 of mild-COVID-19 individuals, we detected a specific visuoconstructive deficit, which was associated with changes in molecular and structural brain imaging"
Coronavirus effects linger in once-healthy brains. Long COVID's toll feared in Louisiana.
“‘My great concern is that there could be a wave of dementia cases over the next 5 to 10 years that can be directly traced back to this pandemic…It is a vascular virus…It does bad things to blood vessels in our bodies.’”
Nej mc2033369
Microvascular Injury in the Brains of Patients with Covid-19
What Drives Post-COVID Cognitive Changes?
Covid brain damage: Millions have persistent cognitive issues after SARS-CoV-2 due to vascular injury...even young & healthy who had mild case.
"However, there are not yet effective laboratory tests or treatments for COVID-associated cognitive changes."