How long COVID could lift the fog on neurocognitive disorders
‘I’m a shell of myself. My physical issues aren’t half as bad as my brain problems. You can say brain fog, but that doesn’t come close to doing it justice.’”
Pioneering discovery and therapeutics at the brain-vascular-immune interface
A new paper in Cell, “Pioneering discovery and therapeutics at the brain-vascular-immune interface,” describes COVID-19 as a neurological disease alongside multiple sclerosis, Alzheimer’s, stroke and traumatic brain injury.
“COVID-19 can accelerate progression of dementia and induce BBB disruption and inflammatory blood clots causally linked with neuroinflammation and neuronal loss.8 In neurodevelopmental disorders, prematurity and perinatal hypoxia that trigger brain hemorrhage and BBB disruption are risk factors for cerebral palsy, intellectual disability, and autism. Collectively, these risk factors highlight the interconnected vascular and immune triggers of neurological diseases.”
Quantitative susceptibility mapping at 7 T in COVID-19: brainstem effects and outcome associations | Brain | Oxford Academic
“In COVID-19 survivors, the MR susceptibility increased in the medulla, pons and midbrain regions of the brainstem. Specifically, there was increased susceptibility in the inferior medullary reticular formation and the raphe pallidus and obscurus. In these regions, patients with higher tissue susceptibility had worse acute disease severity, higher acute inflammatory markers, and significantly worse functional recovery.”
In COVID-19 survivors, the MR susceptibility increased in the medulla, pons and midbrain regions of the brainstem. Specifically, there was increased susceptibility in the inferior medullary reticular formation and the raphe pallidus and obscurus. In these regions, patients with higher tissue susceptibility had worse acute disease severity, higher acute inflammatory markers, and significantly worse functional recovery.
COVID-19 related cognitive, structural and functional brain changes among Italian adolescents and young adults: a multimodal longitudinal case-control study
“COVID-19 related cognitive, structural and functional brain changes among Italian adolescents and young adults: a multimodal longitudinal case-control study”
Driving Under the Cognitive Influence of COVID-19: Exploring the Impact of Acute SARS-CoV-2 Infection on Road Safety | Neurology
"The study suggests that acute COVID-19, regardless of Long COVID status, is linked to an increased risk of car crashes presumably due to neurologic changes caused by SARS-CoV-2."
A 43% increase since 2019.
A 43% increase cognitive disabilities since 2019.
“This is tragic and horrifying. And it’s going to get progressively worse as we’re all systematically reinfected.”
Severe Covid infections can inflame brain’s ‘control centre’, research says
“Severe Covid infections can drive inflammation in the brain’s ‘control centre’ researchers say, leading to damage that may explain the long-term breathlessness, fatigue and anxiety some patients experience.
MRI scans reveal the damage long Covid does to your brain
“MRI scans reveal the damage long Covid does to your brain
Researchers suggested lasting Covid symptoms might be an indirect effect of brainstem inflammatory injury”
Whoopi Goldberg Commiserates With Fellow-Covid Sufferer Joe Biden: “Sometimes I Go For A Word And It’s Not There”
Whoopi Goldberg, who just had her 4th COVID infection, joked about her post infection brain damage on TV.
“I’m just getting over COVID – again – and I can barely remember anybody’s name. There are times when I go for a word and it’s not there.”
Emerging signs of Alzheimer‐like tau hyperphosphorylation and neuroinflammation in the brain post recovery from COVID‐19
Emerging signs of Alzheimer’s-like pathology in brains if people recovered from COVID-19, even though no direct SARS-CoV-2 invasion was detected
Study shows that COVID-19 causes cognitive decline among those without long COVID symptoms
“A new study in eClinicalMedicine has found that healthy volunteers infected with SARS-CoV-2 had measurably worse cognitive function for up to a year after infection when compared to uninfected controls. Significantly, infected controls did not report any symptoms related to these cognitive deficits, indicating that they were unaware of them.”
A new study in eClinicalMedicine has found that healthy volunteers infected with SARS-CoV-2 had measurably worse cognitive function for up to a year after infection when compared to uninfected controls. Significantly, infected controls did not report any symptoms related to these cognitive deficits, indicating that they were unaware of them. The net effect is that potentially billions of people worldwide with a his
French doctors warn that even mild COVID-19 can cause acute Cerebellitis that is difficult to diagnose - Thailand Medical News
French doctors warn that even mild COVID-19 can cause acute Cerebellitis that is difficult to diagnose and life-threatening
Covid Brain
“But this week 2 new publications have substantially added to our understanding of the extent that Covid can impair cognitive function across the full gamut— from young, healthy individuals with mild infections to older, hospitalized patients with severe Covid.”
Changes in memory and cognition during the SARS-CoV-2 human challenge study
“Patient-reported outcomes and cross-sectional evidence show an association between COVID-19 and persistent cognitive problems.”
Long COVID is not the same for everyone: a hierarchical cluster analysis of Long COVID symptoms 9 and 12 months after SARS-CoV-2 test - BMC Infectious Diseases
“Our results suggest that Long COVID is not the same for everyone.”
Our results suggest that Long COVID is not the same for everyone.
Cognitive and psychiatric symptom trajectories 2–3 years after hospital admission for COVID-19: a longitudinal, prospective cohort study in the UK
“Participants had worse cognitive scores than would be expected on the basis of their sociodemographic characteristics across all cognitive domains tested (average score 0·71 SD below the mean [IQR 0·16–1·04]; p<0·0001). Most participants reported at least mild depression (263 [74·5%] of 353), anxiety (189 [53·5%] of 353), fatigue (220 [62·3%] of 353), or subjective cognitive decline (184 [52·1%] of 353), and more than a fifth reported severe depression (79 [22·4%] of 353), fatigue (87 [24·6%] of 353), or subjective cognitive decline (88 [24·9%] of 353). Depression, anxiety, and fatigue were worse at 2–3 years than at 6 months or 12 months, with evidence of both worsening of existing symptoms and emergence of new symptoms. Symptoms at 2–3 years were not predicted by the severity of acute COVID-19 illness, but were strongly predicted by the degree of recovery at 6 months”
Participants had worse cognitive scores than would be expected on the basis of their sociodemographic characteristics across all cognitive domains tested (average score 0·71 SD below the mean [IQR 0·16–1·04]; p<0·0001). Most participants reported at least mild depression (263 [74·5%] of 353), anxiety (189 [53·5%] of 353), fatigue (220 [62·3%] of 353), or subjective cognitive decline (184 [52·1%] of 353), and more than a fifth reported severe depression (79 [22·4%] of 353), fatigue (87 [24·6%] of 353), or subjective cognitive decline (88 [24·9%] of 353). Depression, anxiety, and fatigue were worse at 2–3 years than at 6 months or 12 months, with evidence of both worsening of existing symptoms and emergence of new symptoms. Symptoms at 2–3 years were not predicted by the severity of acute COVID-19 illness, but were strongly predicted by the degree of recovery at 6 months
Neurological complications caused by SARS-CoV-2
Very comprehensive evaluation of known neurological damage from SarsCov2:
“The pathogenesis of neurological disorders caused by SARS-CoV-2 involves several mechanisms. First, SARS-CoV-2 could enter the brain through retrograde transmission & hematogenous routes & disrupt brain function & structure, thus causing or exacerbating neurological disorders…”
Research Shows Severe COVID-19 Contributes to Long-Lasting Cognitive Impairment - InventUM
“We found persistent subjective and objective cognitive issues even two years after infection, including brain fog, word-finding problems, working memory deficits and reduced processing speed.” “Most Patients Have Never Fully Recovered”
“We found persistent subjective and objective cognitive issues even two years after infection, including brain fog, word-finding problems, working memory deficits and reduced processing speed.”
“Most Patients Have Never Fully Recovered”
“Their research found patients who had COVID-19 were 60% more likely to suffer from mental health problems than those who were not infected. When hospitalized, the likelihood jumped to 86%.”
Another great thread by Laura Miers:
“Their research found patients who had COVID-19 were 60% more likely to suffer from mental health problems than those who were not infected. When hospitalized, the likelihood jumped to 86%.”
We are deliberately ignoring this & normalizing reinfection.”
One infection in ‘22, took Paxlovid. Still got TBI. Not recovered. Was ultra marathon runner, cyclist, executive. Fit, active. Everyone is at risk of poor outcome, even infants. Thanks for raising awareness.
“One infection in ‘22, took Paxlovid. Still got TBI. Not recovered. Was ultra marathon runner, cyclist, executive. Fit, active. Everyone is at risk of poor outcome, even infants.”
Long COVID patients have similar brain activity to those with dementia, UK researchers find
“Some patients with COVID see similar brain changes to people with such neurodegenerative disorders as Alzheimer’s, according to University of Kentucky researchers.”
Kentucky research links long COVID brain fog to Alzheimer’s | Lexingt…
“Some patients with COVID see similar brain changes to people with such neurodegenerative disorders as Alzheimer’s, according to University of Kentucky researchers.”
Some patients with COVID see similar brain changes to people with such neurodegenerative disorders as Alzheimer’s, according to University of Kentucky researchers.
BLOOMBERG TWEETING OUT COVID has all sorts of cognitive issues and of a coming SURGE OF DEMENTIA?
Does Covid Lead to Dementia? Here's What the Virus May Have Done to Y…
Non paywall version of catalogued Bloomberg article
Scientists are worried that persisting cognitive issues may signal a coming surge of dementia and other mental conditions
What We Know About Covid’s Impact on Your Brain
“Scientists are worried that persisting cognitive issues may signal a coming surge of dementia and other mental conditions”
SARS-CoV-2 evolves faster in the brain, shedding light on long COVID
“A new study published in Nature Microbiology has revealed that SARS-CoV-2, the virus responsible for COVID-19, evolves more rapidly in the brain than in the lungs, possibly explaining some of the neurological symptoms associated with the disease.”
Writers and editors aren't even bothering to look at *their own articles* before publishing bad studies on lockdowns. It's disturbing.
Note author of both articles is same person. We are in age of ALMOST UNIVERSAL cognitive decline and memory loss.
“Writers and editors aren't even bothering to look at their own articles before publishing bad studies on lockdowns. It's disturbing.”
None of the 'lockdowns aged teen brains' media articles mention:
“None of the 'lockdowns aged teen brains' media articles mention:
- The study did not control for covid infection in a population where
- to QUOTE THE STUDY 'covid-19 was widespread'
- 100s of study show the covid virus infects the brain Off-the-scale journalistic malpractice”
Today, , decided to publish a story on a study purposefully designed to produce lies funded by with the intention of lying to the public to convince them that schools closing for a few weeks in 2020 caused changes in the brains of children.
“Today, @CNN, @UW decided to publish a story on a study purposefully designed to produce lies funded by @JeffBezos with the intention of lying to the public to convince them that schools closing for a few weeks in 2020 caused changes in the brains of children.”
A thread with multiple studies:
Spike Mutations Help SARS-CoV-2 Infect the Brain - News Center
“It’s still not known if long COVID is caused by direct infection of cells in the brain or due to some adverse immune response that persists beyond the infection,”