Pioneering discovery and therapeutics at the brain-vascular-immune interface
A new paper in Cell, “Pioneering discovery and therapeutics at the brain-vascular-immune interface,” describes COVID-19 as a neurological disease alongside multiple sclerosis, Alzheimer’s, stroke and traumatic brain injury.
“COVID-19 can accelerate progression of dementia and induce BBB disruption and inflammatory blood clots causally linked with neuroinflammation and neuronal loss.8 In neurodevelopmental disorders, prematurity and perinatal hypoxia that trigger brain hemorrhage and BBB disruption are risk factors for cerebral palsy, intellectual disability, and autism. Collectively, these risk factors highlight the interconnected vascular and immune triggers of neurological diseases.”
Quantitative susceptibility mapping at 7 T in COVID-19: brainstem effects and outcome associations | Brain | Oxford Academic
“In COVID-19 survivors, the MR susceptibility increased in the medulla, pons and midbrain regions of the brainstem. Specifically, there was increased susceptibility in the inferior medullary reticular formation and the raphe pallidus and obscurus. In these regions, patients with higher tissue susceptibility had worse acute disease severity, higher acute inflammatory markers, and significantly worse functional recovery.”
In COVID-19 survivors, the MR susceptibility increased in the medulla, pons and midbrain regions of the brainstem. Specifically, there was increased susceptibility in the inferior medullary reticular formation and the raphe pallidus and obscurus. In these regions, patients with higher tissue susceptibility had worse acute disease severity, higher acute inflammatory markers, and significantly worse functional recovery.
COVID-19 related cognitive, structural and functional brain changes among Italian adolescents and young adults: a multimodal longitudinal case-control study
“COVID-19 related cognitive, structural and functional brain changes among Italian adolescents and young adults: a multimodal longitudinal case-control study”
Driving Under the Cognitive Influence of COVID-19: Exploring the Impact of Acute SARS-CoV-2 Infection on Road Safety | Neurology
"The study suggests that acute COVID-19, regardless of Long COVID status, is linked to an increased risk of car crashes presumably due to neurologic changes caused by SARS-CoV-2."
Severe Covid infections can inflame brain’s ‘control centre’, research says
“Severe Covid infections can drive inflammation in the brain’s ‘control centre’ researchers say, leading to damage that may explain the long-term breathlessness, fatigue and anxiety some patients experience.
Study shows that COVID-19 causes cognitive decline among those without long COVID symptoms
“A new study in eClinicalMedicine has found that healthy volunteers infected with SARS-CoV-2 had measurably worse cognitive function for up to a year after infection when compared to uninfected controls. Significantly, infected controls did not report any symptoms related to these cognitive deficits, indicating that they were unaware of them.”
A new study in eClinicalMedicine has found that healthy volunteers infected with SARS-CoV-2 had measurably worse cognitive function for up to a year after infection when compared to uninfected controls. Significantly, infected controls did not report any symptoms related to these cognitive deficits, indicating that they were unaware of them. The net effect is that potentially billions of people worldwide with a his
“But this week 2 new publications have substantially added to our understanding of the extent that Covid can impair cognitive function across the full gamut— from young, healthy individuals with mild infections to older, hospitalized patients with severe Covid.”
Long COVID is not the same for everyone: a hierarchical cluster analysis of Long COVID symptoms 9 and 12 months after SARS-CoV-2 test - BMC Infectious Diseases
“Our results suggest that Long COVID is not the same for everyone.”
Our results suggest that Long COVID is not the same for everyone.
Cognitive and psychiatric symptom trajectories 2–3 years after hospital admission for COVID-19: a longitudinal, prospective cohort study in the UK
“Participants had worse cognitive scores than would be expected on the basis of their sociodemographic characteristics across all cognitive domains tested (average score 0·71 SD below the mean [IQR 0·16–1·04]; p<0·0001). Most participants reported at least mild depression (263 [74·5%] of 353), anxiety (189 [53·5%] of 353), fatigue (220 [62·3%] of 353), or subjective cognitive decline (184 [52·1%] of 353), and more than a fifth reported severe depression (79 [22·4%] of 353), fatigue (87 [24·6%] of 353), or subjective cognitive decline (88 [24·9%] of 353). Depression, anxiety, and fatigue were worse at 2–3 years than at 6 months or 12 months, with evidence of both worsening of existing symptoms and emergence of new symptoms. Symptoms at 2–3 years were not predicted by the severity of acute COVID-19 illness, but were strongly predicted by the degree of recovery at 6 months”
Participants had worse cognitive scores than would be expected on the basis of their sociodemographic characteristics across all cognitive domains tested (average score 0·71 SD below the mean [IQR 0·16–1·04]; p<0·0001). Most participants reported at least mild depression (263 [74·5%] of 353), anxiety (189 [53·5%] of 353), fatigue (220 [62·3%] of 353), or subjective cognitive decline (184 [52·1%] of 353), and more than a fifth reported severe depression (79 [22·4%] of 353), fatigue (87 [24·6%] of 353), or subjective cognitive decline (88 [24·9%] of 353). Depression, anxiety, and fatigue were worse at 2–3 years than at 6 months or 12 months, with evidence of both worsening of existing symptoms and emergence of new symptoms. Symptoms at 2–3 years were not predicted by the severity of acute COVID-19 illness, but were strongly predicted by the degree of recovery at 6 months
Very comprehensive evaluation of known neurological damage from SarsCov2:
“The pathogenesis of neurological disorders caused by SARS-CoV-2 involves several mechanisms. First, SARS-CoV-2 could enter the brain through retrograde transmission & hematogenous routes & disrupt brain function & structure, thus
causing or exacerbating neurological disorders…”
Research Shows Severe COVID-19 Contributes to Long-Lasting Cognitive Impairment - InventUM
“We found persistent subjective and objective cognitive issues even two years after infection, including brain fog, word-finding problems, working memory deficits and reduced processing speed.”
“Most Patients Have Never Fully Recovered”
“We found persistent subjective and objective cognitive issues even two years after infection, including brain fog, word-finding problems, working memory deficits and reduced processing speed.”
“Most Patients Have Never Fully Recovered”
“Their research found patients who had COVID-19 were 60% more likely to suffer from mental health problems than those who were not infected. When hospitalized, the likelihood jumped to 86%.”
Another great thread by Laura Miers:
“Their research found patients who had COVID-19 were 60% more likely to suffer from mental health problems than those who were not infected. When hospitalized, the likelihood jumped to 86%.”
We are deliberately ignoring this & normalizing reinfection.”
One infection in ‘22, took Paxlovid. Still got TBI. Not recovered. Was ultra marathon runner, cyclist, executive. Fit, active. Everyone is at risk of poor outcome, even infants. Thanks for raising awareness.
“One infection in ‘22, took Paxlovid. Still got TBI. Not recovered. Was ultra marathon runner, cyclist, executive. Fit, active. Everyone is at risk of poor outcome, even infants.”
Long COVID patients have similar brain activity to those with dementia, UK researchers find
“Some patients with COVID see similar brain changes to people with such neurodegenerative disorders as Alzheimer’s, according to University of Kentucky researchers.”
Kentucky research links long COVID brain fog to Alzheimer’s | Lexingt…
“Some patients with COVID see similar brain changes to people with such neurodegenerative disorders as Alzheimer’s, according to University of Kentucky researchers.”
Some patients with COVID see similar brain changes to people with such neurodegenerative disorders as Alzheimer’s, according to University of Kentucky researchers.
SARS-CoV-2 evolves faster in the brain, shedding light on long COVID
“A new study published in Nature Microbiology has revealed that SARS-CoV-2, the virus responsible for COVID-19, evolves more rapidly in the brain than in the lungs, possibly explaining some of the neurological symptoms associated with the disease.”
Today, , decided to publish a story on a study purposefully designed to produce lies funded by with the intention of lying to the public to convince them that schools closing for a few weeks in 2020 caused changes in the brains of children.
“Today, @CNN, @UW decided to publish a story on a study purposefully designed to produce lies funded by @JeffBezos with the intention of lying to the public to convince them that schools closing for a few weeks in 2020 caused changes in the brains of children.”
Spike Mutations Help SARS-CoV-2 Infect the Brain - News Center
“It’s still not known if long COVID is caused by direct infection of cells in the brain or due to some adverse immune response that persists beyond the infection,”
Gray matter thickness may be reduced in specific brain areas after SARS-CoV-2 Omicron infection
Study on 61 men MRI scanned pre and post omicron covid. "Decrease in gray matter thickness in the left precuneus and right lateral occipital regions of the brain. Ratio of the right hippocampus volume to total brain volume decreased."
Alzheimer's-like brain changes found in long COVID patients
“New research from the University of Kentucky's Sanders-Brown Center on Aging shows compelling evidence that the cognitive impairments observed in long COVID patients share striking similarities with those seen in Alzheimer's disease and related dementias.”
