Frontiers | SARS-CoV-2 infection increases risk of intracranial hemorrhage
“SARS-CoV-2 infection increases risk of intracranial hemorrhage”
SARS-CoV-2 infection increases risk of intracranial hemorrhage
A case-control study of reaction time deficits in a 3D virtual reality in patients with Post-COVID syndrome
“A case-control study of reaction time deficits in a 3D virtual reality in patients with Post-COVID syndrome”
A case-control study of reaction time deficits in a 3D virtual reality in patients with Post-COVID syndrome
Serotonin reduction in post-acute sequelae of viral infection
Long COVID is linked to reduced serotonin levels, which are driven by viral RNA-induced type I interferons (IFNs).
Peripheral serotonin deficiency impairs cognition by reducing vagal nerve signaling, affecting hippocampal responses and memory.
Studies re Long Covid insist on stating the % of people who succumb to this sequelae. I’ve seen incident rates from 3.5% up to 38% (after 3rd infection).
“GreyBut what every single one of these studies fail to mention is that the reduction in grey matter occurs in 100% of individuals"
A thread with studies:
Covid damages the frontal lobe of the brain.
It’s not “empathy burnout.” It’s Covid brain damage. From neuropathologist: “Covid damages the frontal lobe of the brain.
Many areas of the frontal lobe are essential to the execution of empathy.
Most people are on their 3rd/4th+ infection/s already.
But it’s ‘empathy burnout”’
At least they’re recognising the loss of function I suppose. Many can’t.”
Limbic system damage following SARS-CoV2 infection | Brain Communications | Oxford Academic
Limbic system damage from Covid:
SARS-CoV-2 is a neurotropic virus that may cause long-term neurological symptoms by damaging the limbic system.
This research shows that COVID-19 can impair emotion recognition, memory, and olfactory abilities, with altered brain connectivity patterns.
The buddy from college I talk about every now and again.
“The buddy from college I talk about every now and again.
He’s prolly 50 or so. He posted this a few days ago. He has already had a rough go of it, he has a daughter he is devoted to, and who loves him immensely.
I am as sad as I am angry. “
Ugh. The more we learn about it, the uglier it looks.
“Ugh. The more we learn about it, the uglier it looks.
This, again, speaks to my point about tail risk in an emergent situation: it’s at least as bad as it looks. It may be worse.
We are badly underestimating the consequences of delayed risk. It’s a reckless approach. (1/)”
SARS-CoV-2 Invasion and Pathological Links to Prion Disease
Nearly half of those infected with SARS-CoV-2 experience long-term neurological problems, including brain fog and memory issues.
An infection may accelerate or exacerbate prion diseases like Creutzfeldt–Jakob disease, leading to rapid neurodegeneration.
Worse, most people don’t even notice it has happened to themselves.
“Worse, most people don’t even notice it has happened to themselves.
But I can tell you we who continue to mask and have many fewer COVID infections can see the growing cognitive damage in more and more people around us.
Memory problems, like recall and word finding delays. Weakness and fatigue and motor control impairment. Growing executive function and emotional regulation deficits.
More and more friends disables and forced out of work or school by Long COVID symptoms.
It’s scary to witness the broad societal decline, and dispiriting to see so many governments and Public Health agencies persist in minimizing the growing problem.”
Doctors struggle to treat long Covid patients in India; researchers point to inadequate studies
Dr. Arun Garg (The Medicity, Gurugram, India) said, "[I notice] a spike in stroke cases among young patients not suffering from known risk factors such as diabetes, hypertension and obesity.. Similarly, we are seeing more cases of encephalopathy, swelling of the brain, without reason and having a confused state of mind following one or two days of fever. Their MRI scans show no changes. These patients have increased significantly after Covid.. [Currently,] Other than routine blood tests that measure inflammation, we do antibody tests to look for direct markers. In many of these patients, we are finding rare antibodies which are very new to us and were not there pre-Covid."
Can I reassert that with SARS-CoV-2 induced brain damage, it won’t be a lessening of intellect that you’ll be seeing first, but behavioural changes such as disinhibition, emotional lability, risk taking & impulsivity.
“Can I reassert that with SARS-CoV-2 induced brain damage, it won’t be a lessening of intellect that you’ll be seeing first, but behavioural changes such as disinhibition, emotional lability, risk taking & impulsivity.
Frontal lobe damage impairs behavioural regulation.” Thread:
Cognitive profile following COVID-19 infection: Clinical predictors leading to neuropsychological impairment
Covid itself causes cognitive impairment. From 2020, prior to Covid vaccination of any kind:
“In our cohort of COVID-19 patients neurologic manifestations were frequent, including cognitive impairment.”
COVID survivors may develop dementia
“COVID-19 survivors show signs of significant cognitive deficits which could become dementia even a year after having the virus.. The team [in India] found that more than 80% of people tested reported at least one of four symptoms – depression, anxiety, stress and insomnia – ranging from mild to severe.. At least 6.1% of the patients were diagnosed with mild cognitive impairment and 4% developed dementia. More than 60% of the patients experienced a loss of taste and smell during the active phase of the infection. This could alter the function of brain areas linked to cognitive ability and emotional well-being.."
COVID-19 survivors show signs of significant cognitive deficits which could become dementia even a year after having the virus1. They also have an increased risk of depression, anxiety and disrupted sleep.
Advanced brain fMRI showed low glutathione : r/covidlonghaulers
“Hey all. I thought I would just throw this out there. I had an advanced brain fMRI that was able to show a bunch of brain biomarkers. The only significant finding was that I had low brain glutathione. I was at .56 mM and the normal range is 1-2 mM. He told me this is a large deficiency.
He said this would usually indicate CFS, brain fog, and low energy.”
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COVID Linked to Lower IQ, Poor Memory and Other Negative Impacts on Brain Health
“COVID-19 poses a serious risk to brain health, even in mild cases, and the effects are now being revealed at the population level,"
COVID-19 poses a serious risk to brain health, even in mild cases, and the effects are now being revealed at the population level,"
Recorded this video on the microscope yesterday. A single infected cell arrives on the brain inside a blood vessel. Don't underestimate how much neuroinflammation one infected cell can cause.
“Recorded this video on the microscope yesterday. A single #SARSCoV2 infected cell arrives on the brain inside a blood vessel. Don't underestimate how much neuroinflammation one infected cell can cause. Brain-vascular-immune interface is the future of neuroscience #NeuroCovid”
How long COVID could lift the fog on neurocognitive disorders
‘I’m a shell of myself. My physical issues aren’t half as bad as my brain problems. You can say brain fog, but that doesn’t come close to doing it justice.’”
Pioneering discovery and therapeutics at the brain-vascular-immune interface
A new paper in Cell, “Pioneering discovery and therapeutics at the brain-vascular-immune interface,” describes COVID-19 as a neurological disease alongside multiple sclerosis, Alzheimer’s, stroke and traumatic brain injury.
“COVID-19 can accelerate progression of dementia and induce BBB disruption and inflammatory blood clots causally linked with neuroinflammation and neuronal loss.8 In neurodevelopmental disorders, prematurity and perinatal hypoxia that trigger brain hemorrhage and BBB disruption are risk factors for cerebral palsy, intellectual disability, and autism. Collectively, these risk factors highlight the interconnected vascular and immune triggers of neurological diseases.”
Quantitative susceptibility mapping at 7 T in COVID-19: brainstem effects and outcome associations | Brain | Oxford Academic
“In COVID-19 survivors, the MR susceptibility increased in the medulla, pons and midbrain regions of the brainstem. Specifically, there was increased susceptibility in the inferior medullary reticular formation and the raphe pallidus and obscurus. In these regions, patients with higher tissue susceptibility had worse acute disease severity, higher acute inflammatory markers, and significantly worse functional recovery.”
In COVID-19 survivors, the MR susceptibility increased in the medulla, pons and midbrain regions of the brainstem. Specifically, there was increased susceptibility in the inferior medullary reticular formation and the raphe pallidus and obscurus. In these regions, patients with higher tissue susceptibility had worse acute disease severity, higher acute inflammatory markers, and significantly worse functional recovery.
COVID-19 related cognitive, structural and functional brain changes among Italian adolescents and young adults: a multimodal longitudinal case-control study
“COVID-19 related cognitive, structural and functional brain changes among Italian adolescents and young adults: a multimodal longitudinal case-control study”
Driving Under the Cognitive Influence of COVID-19: Exploring the Impact of Acute SARS-CoV-2 Infection on Road Safety | Neurology
"The study suggests that acute COVID-19, regardless of Long COVID status, is linked to an increased risk of car crashes presumably due to neurologic changes caused by SARS-CoV-2."
A 43% increase since 2019.
A 43% increase cognitive disabilities since 2019.
“This is tragic and horrifying. And it’s going to get progressively worse as we’re all systematically reinfected.”
Severe Covid infections can inflame brain’s ‘control centre’, research says
“Severe Covid infections can drive inflammation in the brain’s ‘control centre’ researchers say, leading to damage that may explain the long-term breathlessness, fatigue and anxiety some patients experience.
MRI scans reveal the damage long Covid does to your brain
“MRI scans reveal the damage long Covid does to your brain
Researchers suggested lasting Covid symptoms might be an indirect effect of brainstem inflammatory injury”
Whoopi Goldberg Commiserates With Fellow-Covid Sufferer Joe Biden: “Sometimes I Go For A Word And It’s Not There”
Whoopi Goldberg, who just had her 4th COVID infection, joked about her post infection brain damage on TV.
“I’m just getting over COVID – again – and I can barely remember anybody’s name. There are times when I go for a word and it’s not there.”
Emerging signs of Alzheimer‐like tau hyperphosphorylation and neuroinflammation in the brain post recovery from COVID‐19
Emerging signs of Alzheimer’s-like pathology in brains if people recovered from COVID-19, even though no direct SARS-CoV-2 invasion was detected
Study shows that COVID-19 causes cognitive decline among those without long COVID symptoms
“A new study in eClinicalMedicine has found that healthy volunteers infected with SARS-CoV-2 had measurably worse cognitive function for up to a year after infection when compared to uninfected controls. Significantly, infected controls did not report any symptoms related to these cognitive deficits, indicating that they were unaware of them.”
A new study in eClinicalMedicine has found that healthy volunteers infected with SARS-CoV-2 had measurably worse cognitive function for up to a year after infection when compared to uninfected controls. Significantly, infected controls did not report any symptoms related to these cognitive deficits, indicating that they were unaware of them. The net effect is that potentially billions of people worldwide with a his
French doctors warn that even mild COVID-19 can cause acute Cerebellitis that is difficult to diagnose - Thailand Medical News
French doctors warn that even mild COVID-19 can cause acute Cerebellitis that is difficult to diagnose and life-threatening
Covid Brain
“But this week 2 new publications have substantially added to our understanding of the extent that Covid can impair cognitive function across the full gamut— from young, healthy individuals with mild infections to older, hospitalized patients with severe Covid.”