EXTREME and incomplete oversimplification of the many complex neurological issues caused by SarsCov2, but important facet of the vaguely defined “brain fog” of Long Covid and post-acute Covid lingering symptoms.

“Neurological symptoms have been widely observed in COVID-19 patients, with many survivors exhibiting persistent neurological and cognitive impairment. New research from the University of Minnesota found that COVID-19 triggers inflammation in the brain, which is linked to many COVID-related symptoms such as fatigue and ‘brain fog.’”

“The most helpful #MECFS #LongCovid educational series out there right now is Dr. Jarred Youngers video series on "Neuroinflammation, Pain, and Fatigue".

Start at the beginning or jump in as your interest is piqued. There are now 28 shortish videos (most under 15min) and this series will provide an incredible grounding in all things neuroinflammation.

Dr. Younger is all about the 'tools' and 'interventions' and patient education and has done more to educate us about available interventions for neuroinflammation than any other researcher.”

Study from CAMH found, via PET scans, elevated levels of the protein TSPO, a brain marker of inflammation, in patients with onset of depression in long covid

more than 200 million globally may experience lingering neurological symptoms from COVID, including depression, memory impairment, slower motor control, low motivation and energy, for months to even years due to brain inflammation from long COVID

this along side everything we have learned in the last 2.5 years ( much summarized in the lit review done by Stanford and Yale, linked in the comments ) moves us a step closer in understanding the underlying biological mechanisms behind these symptoms

Interesting study: Inflammatory and mental health sequelae of COVID-19

"The COVID-19 pandemic has caused significant negative consequences to mental health. Increased inflammatory factors and neuropsychiatric symptoms, such as cognitive impairment (“brain fog”), depression, and anxiety are associated with long COVID [post-acute sequelae of SARS-CoV-2 infection (PASC), termed neuro-PASC]"

➡️Biomarker: MIG

"Growing evidence supporting the usefulness of circulating MIG(monokine induced by gamma interferon (IFN-γ) aka CXCL9) levels as a biomarker reflecting IFN-γ production, which is important because individuals with neuro-#PASC/ neuro-#Longcovid have elevated IFN-γ responses to internal SARS-CoV-2 proteins"

COVID-19: Long COVID Neuroinflammation shown in PET scan

A study shows positron emission tomography (PET) scan imaging of two Long COVID patients compared with controls (

Attention medics. Does your patient have new-onset psychosis? hallucinations? personality changes post Covid?

They have neuro inflammation Encephalitis is not uncommon in #LongCovid, esp in the first months post infection. Psych is not appropriate. #MedTwitter #MedEd #TeamGP