Fibrin drives thromboinflammation and neuropathology in COVID-19
Just published @Nature How fibrin drives brain inflammation in acute and #LongCovid and that a monoclonal antibody to fibrin protects against microglial activation
Blood–brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment
Covid can disrupt the blood brain barrier, the shield that protects the nervous system making it ‘leaky’.
Inflammation may link COVID-19 severity to the onset of neurological symptoms
“neuroinflammation is independent of disease severity and may be one of the main causes of neurological disorders associated with COVID-19. She points out that even patients with milder cases showed significant changes in the CSF, suggesting that the body's inflammatory response may affect the brain in ways not yet fully understood.”
neuroinflammation is independent of disease severity and may be one of the main causes of neurological disorders associated with COVID-19. She points out that even patients with milder cases showed significant changes in the CSF, suggesting that the body's inflammatory response may affect the brain in ways not yet fully understood.
COVID-related loss of smell tied to changes in the brain | CIDRAP
“On MRI conducted during the game, loss of smell was associated with decreased functional activity during decision-making, loss of white-matter integrity, and thinning of the outer layer of the cerebrum in the parietal regions (responsible for processing sensory input, understanding spatial relationships, and how to navigate).”
Brain effects of mild COVID-19 in healthy young adults: A pilot study
“Our pilot data suggests that mild COVID-19 may result in brain pathology and impact neurocognitive function in younger adults in a manner parallel to prior findings in older individuals. Though findings may not generalize to other SARS-CoV-2 variants, larger longitudinal studies of mild COVID-19 should be undertaken to understand the potential clinical implications of these findings over the longer term.”
Our pilot data suggests that mild COVID-19 may result in brain pathology and impact neurocognitive function in younger adults in a manner parallel to prior findings in older individuals. Though findings may not generalize to other SARS-CoV-2 variants, larger longitudinal studies of mild COVID-19 should be undertaken to understand the potential clinical implications of these findings over the longer term.
Study uncovers the basis of COVID-19-related brain fog | University of Minnesota
EXTREME and incomplete oversimplification of the many complex neurological issues caused by SarsCov2, but important facet of the vaguely defined “brain fog” of Long Covid and post-acute Covid lingering symptoms.
“Neurological symptoms have been widely observed in COVID-19 patients, with many survivors exhibiting persistent neurological and cognitive impairment. New research from the University of Minnesota found that COVID-19 triggers inflammation in the brain, which is linked to many COVID-related symptoms such as fatigue and ‘brain fog.’”
Patients recovering from COVID-19 who presented with anosmia during their acute episode have behavioral, functional, and structural brain alterations
“Patients recovering from COVID-19 who presented with anosmia during their acute episode have behavioral, functional, and structural brain alterations”
Neuroinflammation After COVID-19 With Persistent Depressive and Cognitive Symptoms
Neuroinflammation After COVID-19 With Persistent Depressive and Cognitive Symptoms
Wes Wilson on Twitter
Study from CAMH found, via PET scans, elevated levels of the protein TSPO, a brain marker of inflammation, in patients with onset of depression in long covid
more than 200 million globally may experience lingering neurological symptoms from COVID, including depression, memory impairment, slower motor control, low motivation and energy, for months to even years due to brain inflammation from long COVID
this along side everything we have learned in the last 2.5 years ( much summarized in the lit review done by Stanford and Yale, linked in the comments ) moves us a step closer in understanding the underlying biological mechanisms behind these symptoms
CAMH study confirms ongoing brain inflammation associated with long COVID
"What’s new about this study is that it shows that inflammation is hanging around for a long time in the brains of people with long COVID even after only mild to moderate symptoms of active COVID-19,”
Harry Spoelstra on Twitter
Interesting study: Inflammatory and mental health sequelae of COVID-19
"The COVID-19 pandemic has caused significant negative consequences to mental health. Increased inflammatory factors and neuropsychiatric symptoms, such as cognitive impairment (“brain fog”), depression, and anxiety are associated with long COVID [post-acute sequelae of SARS-CoV-2 infection (PASC), termed neuro-PASC]"
➡️Biomarker: MIG
"Growing evidence supporting the usefulness of circulating MIG(monokine induced by gamma interferon (IFN-γ) aka CXCL9) levels as a biomarker reflecting IFN-γ production, which is important because individuals with neuro-#PASC/ neuro-#Longcovid have elevated IFN-γ responses to internal SARS-CoV-2 proteins"
SARS-CoV-2 Spike protein alters microglial purinergic signaling
"Evidence demonstrates that SARS-CoV-2 Spike protein can reach different brain regions, irrespective of viral brain replication resulting in activation of pattern recognition receptors (PRRs) and neuroinflammation."
laurie allee on Twitter
"Evidence demonstrates that SARS-CoV-2 Spike protein can reach different brain regions, irrespective of viral brain replication resulting in activation of pattern recognition receptors (PRRs) and neuroinflammation."
Like a "fire in the brain": COVID can cause brain inflammation
"A new study in the journal Molecular Psychiatry shows for the first time that SARS-2 can trigger the same inflammatory processes seen in patients with Alzheimer's or Parkinson's."
'A silent killer': COVID-19 shown to trigger inflammation in the brain
Another study showing that metabolic pathways activated in brain by covid are similar to the ones that happen in Alzheimer & Parkinson diseases. While the drugs to stop this inflammation are being tested, the inflammation is affecting millions of ppl.
Brain imaging before and after COVID-19 in UK Biobank
"These brain imaging result...hallmarks of a degenerative spread of the disease — or of the virus itself — via olfactory pathways...or of neuroinflammatory events due to the infection, or of the loss of sensory input due to anosmia."
COVID-19 Virus Infects Neurons, Induces Inflammation in the Brains of Rhesus Macaques
"A new study in rhesus macaques shows how the COVID-19 virus can enter the brain and cause inflammation of brain cells"
Brain injury a common consequence of both COVID-19 and influenza
"The present study demonstrated elevated concentrations of brain injury biomarkers in COVID-19 patients...correlated with the presence of autoantibodies and proinflammatory cytokines...(and) evidence of dysregulated immune response even after four months"
Larger gray matter volumes in neuropsychiatric long-COVID syndrome
"Significantly enlarged GMV (gray matter volumes) in long-COVID patients was present in several clusters (spanning fronto-temporal areas, insula, hippocampus, amygdala, basal ganglia, and thalamus in both hemispheres) when compared to controls."
Long COVID is associated with extensive in-vivo neuroinflammation on [18F]DPA-714 PET
COVID-19: Long COVID Neuroinflammation shown in PET scan
A study shows positron emission tomography (PET) scan imaging of two Long COVID patients compared with controls (
Neurovascular injury with complement activation and inflammation in COVID-19
The microvascular injury and inflammation of the brain, with immune complex formation, that can occur from Covid, from in-depth assessment of 9 patient autopsies and controls.
Dr K Fearnley on Twitter
Attention medics. Does your patient have new-onset psychosis? hallucinations? personality changes post Covid?
They have neuro inflammation Encephalitis is not uncommon in #LongCovid, esp in the first months post infection. Psych is not appropriate. #MedTwitter #MedEd #TeamGP
Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation
"Mild respiratory COVID causes prominent neuroinflammation..."