laurie allee on Twitter
How #SARSCoV2 infects/affects brain astrocytes https://pnas.org/doi/10.1073/pnas.2122236119 @PNASNews by @Andrews_MG
@tmturkee
@TheOttolab
@Kriegsteinlab and colleagues
Pnas
How #SARSCoV2 infects/affects brain astrocytes
Mild to moderate COVID causes inflammation of white matter in brain ten months later
"...results of this study suggest that mild to moderate COVID-19 infection is associated with mild microstructural abnormalities in cerebral white matter after acute infection."
COVID Brain Problems May Stem From Attack on Endothelial Cells
"COVID Brain Problems May Stem From Attack on Endothelial Cells — Findings could have implications for treating long COVID"
Neurovascular injury with complement activation and inflammation in COVID-19
"All patients had multifocal vascular damage as determined by leakage of serum proteins into the brain parenchyma. This was accompanied by widespread endothelial cell activation...microthrombi were found adherent to the endothelial cells..."
40% of Older Adults: Newly Identified Form of Dementia Is Shockingly Common
A recent study indicates the prevalence of #brain changes from #limbic-predominant age-related TDP-43 #encephalopathy (#LATE) might be approximately 40% in older adults and as high as 50% in people with #Alzheimer’s disease..."
SARS-CoV-2 is associated with changes in brain structure in UK Biobank
UK researchers scanned the brains of 400 people before and after mild covid, compared them with controls and found:
- greater reduction in grey matter thickness
- greater reduction in global brain size
- greater cognitive decline
- greater change to primary olfactory cortex
COVID-19 Linked to Significant Brain Changes, Shrinkage
Covid linked to significant brain shrinkage: "Even a mild COVID-19 infection can change the brain. People infected had a greater reduction in brain volume and performed worse on cognitive tests than those who did not contract COVID-19."
COVID-19 and neurodegenerative diseases
"many patients with COVID-19 experience a variety of neurological complications...possible mechanisms between COVID-19 and several typical neurodegenerative diseases, particularly Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis"
Selective visuoconstructional impairment following mild COVID-19 with inflammatory and neuroimaging correlation findings
"investigate adults at least four months after recovering from mild COVID-19...In approximately 1/4 of mild-COVID-19 individuals, we detected a specific visuoconstructive deficit, which was associated with changes in molecular and structural brain imaging"
Hiroshi Yasuda (保田浩志) on Twitter
According to a systematic review on the COVID-19 survivors, "Seventy-nine percent of COVID-19 survivors at 1 months and 75% at 3- and 6-month follow-up showed cognitive impairment.."
3 in 4 is a quite high ratio.
S0092 8674(22)00713 9#
"Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation"
S41467 022 30932 1
Neurotoxic amyloidogenic peptides in the proteome of SARS-COV2: potential implications for neurological symptoms in COVID-19
Comprehensive clinical assessment identifies specific neurocognitive deficits in working-age patients with long-COVID
Comprehensive clinical assessment identifies specific neurocognitive deficits in working-age patients with long-COVID
Similarities between Alzheimer’s and long COVID found in new study
New research from Australia: proteins generated by SARSCoV2 can form into aggregations similar to those found in the brains of patients with Alzheimer’s...this mechanism may underpin persistent neurological symptoms such as brain fog seen in long COVID.
The Impact of COVID-19 Infection on Cognitive Function and the Implication for Rehabilitation: A Systematic Review and Meta-Analysis
A new review and meta-analysis finds that #LongCovid substantially impacts cognitive functions but that the effect size depends on the type of function.
You're not imagining 'COVID brain' — here's the latest evidence
COVID cognitive decline more widespread than thought say researchers at Australia's first long-COVID clinic Some sort of cognitive decline was recorded in almost all of the participants, regardless of the severity of the initial infection.
Andrew Ewing on Twitter
Comprehensive thread on Twitter 1/36 Update of the covid and the brain talk I recently gave to Drs at Select Medical Better quality figures More on references to look up: Lancet, NEJM, Nature, Neurology, etc Some new material dispersed and at end Some thoughts on possible treatments (not my expertise)
Rapid vigilance and episodic memory decrements in COVID-19 survivors
Excellent study from Oxford💥💥 This is the first report describing deficits in sustained attention & episodic memory amongst mildly-affected #COVID19 survivors long after the acute illness, in people who were not complaining of long-COVID symptoms
Cognitive impairment from long COVID equivalent to aging 20 years, study finds
"A new study says that cognitive impairment due to long COVID is the equivalent of aging 20 years or losing 10 IQ points."
Covid-19: Long Term Brain Injury
"A series of recent studies document long term brain-damage in as many as one quarter of all those infected regardless of the severity of the initial disease."
Viral respiratory infections and psychosis: A review of the literature and the implications of COVID-19
"Several human coronaviruses (HCoVs) have been associated with psychotic disorders and increasing reports of the neuropsychiatric manifestations of COVID-19 suggest it has neuroinvasive properties similar to those of other HCoVs."
Covid-19 And Parkinson’s Disease Can Be A Dangerous Combination: Expert Tips For Caregivers | TheHealthSite.com
Covid-19 And Parkinson’s Disease Can Be A Dangerous Combination:
The viral disease has affected the brain to quite an extent. The immune response in the brain is what gets affected first and then there is the direct invasion of the coronavirus.
Severe cases of COVID causing cognitive impairment equivalent to ageing 20 years, new study finds
Severe cases of COVID causing cognitive impairment equivalent to ageing 20 years, new study finds
"It is very possible that some of these individuals will never fully recover,"
Tom Andrews on Twitter
Comprehensive thread on Twitter: sleepiness, ophthalmoplegia, Parkinsonism, spontaneous movements, dysuria & constipation which we consider characteristic of lethargic encephalitis, due to the position of the lesions in the brainstem THE OCULAR COMPLICATIONS OF ENCEPHALITIS LETHARGICA
SARS-CoV-2 causes brain inflammation and induces Lewy body formation in macaques
“SARS-CoV-2 causes brain inflammation and Lewy bodies, a hallmark for Parkinson, after an asymptomatic infection in macaques.”
Chris Turnbull on Twitter
Comprehensive thread on Twitter: 1/ Covid New Study Shows bleeding on the brain, neuron death & damage, severe inflammation including the 'mild': cases virus found in cells that line the Brain and brainstem—new insight into Long Covid, strokes and other brain disease
How Effects on the Brain Can Produce Long COVID - Neuroscience News
"Even with mild cases, COVID-19 can cause confusion, delirium, sleepiness, poor cognitive function, intense headaches, and uncomfortable skin sensations. In more severe cases, patients have suffered complications as serious as strokes."
Coronavirus effects linger in once-healthy brains. Long COVID's toll feared in Louisiana.
“‘My great concern is that there could be a wave of dementia cases over the next 5 to 10 years that can be directly traced back to this pandemic…It is a vascular virus…It does bad things to blood vessels in our bodies.’”
Increased incidence of COVID-19 breakthrough cases associated with psychiatric disorders
"In a recent study published in JAMA Network Open, researchers investigated the relationship between past psychiatric disorder diagnoses and breakthrough cases of coronavirus disease 2019 (COVID-19) in fully vaccinated people."