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Some get encephalitis. I think there is a variety of possible causes & potentially these also can differ across the acute/ post acute/ #LongCovid timeline 0-2.5yrs +counting
COVID-19 brain fog | CityNews Toronto
"Bluntly and rather disconcertingly, Pirzada says if someone is dealing with significant brain fog, there isn’t much that can be done...
'We can refer you to a specialist that will see you in the long term, but they won’t know what to do either,'"
The Race to Unravel COVID’s Hidden Link to Alzheimer’s
"In some brains, COVID causes molecular changes that mirror those seen in the brains of people with Alzheimer’s, leading some scientists to believe that long COVID may be an atypical form of the memory-destroying disorder."
COVID-19 brain fog | CityNews Toronto
"Colin Furness, an epidemiologist in Toronto, says that EVERYBODY that gets COVID-19 deals with some brain tissue loss. The question, he says, is how much."
Patients at greater risk of dementia after COVID-19 pneumonia, study finds
Patients hospitalized with COVID-19 pneumonia have a higher risk of being diagnosed with dementia compared to those with other types of pneumonias, according to a new study from the University of Missouri.
Physical, psychological and cognitive profile of post-COVID condition in healthcare workers, Quebec, Canada
"Persistent cognitive and other professionally-disabling sequelae of COVID-19 in essential workers could have critical implications for quality healthcare delivery during and after the pandemic."
Nej mc2033369
Microvascular Injury in the Brains of Patients with Covid-19
David Lee, MD on Twitter
Non-specific white matter hyperintensities on MRI have often been considered benign by most physicians. In this NIH-led study of nine fatal COVID-19 cases, histopathology demonstrated that these punctate areas are indicative of microvascular injury.
laurie allee on Twitter
“This study confirms what we have also seen at Northwestern, that cognitive problems are persistent both in patients who were previously hospitalized and also in patients who had only mild respiratory symptoms,”
Memory loss and 'brain fog' may be side effects of COVID-19, new study shows
Study: Long-term COVID-19 side effects could include memory loss and other cognitive dysfunctions.
Most common cognitive deficits: memory encoding and memory recall, which showed up in 24% and 23% of the participants, respectively.
'They can’t think': Covid patients suffer memory problems months after recovering
"Even younger patients were affected by cognitive impairment and difficulty storing new memories."
Even mild cases of COVID-19 might result in brain shrinkage and impaired cognitive function
"Even mild cases of COVID-19 might result in brain shrinkage and impaired cognitive function"
Long COVID study indicates “something concerning is happening”
"The University of Cambridge-led research found many long COVID patients are experiencing significant and measurable memory or concentration impairments even after mild illness."
When COVID-19 Breaches the Brain
"In the post-COVID-19 participants, researchers found reductions in cognitive function, including greater difficulties in problem-solving, visual attention, and spatial working memory."
COVID-19 May Accelerate Alzheimer's and Other Cognitive Issues
There is no mild Covid.
"These new data point to disturbing trends showing COVID-19 infections leading to lasting cognitive impairment and even Alzheimer’s symptoms,”
What Drives Post-COVID Cognitive Changes?
Covid brain damage: Millions have persistent cognitive issues after SARS-CoV-2 due to vascular injury...even young & healthy who had mild case.
"However, there are not yet effective laboratory tests or treatments for COVID-associated cognitive changes."
SARS-CoV-2 spike protein induces cognitive deficit and anxiety-like behavior in mouse via non-cell autonomous hippocampal neuronal death
"Our behavioral study showed that administration of SARS-CoV-2 spike protein S1 subunit to mouse hippocampus induced cognitive deficit and anxiety-like behavior in vivo. These neurological symptoms were accompanied by neuronal cell death."
Mass cognitive test reveals COVID-19 impact on intellect - Science Museum Group
People who had recovered from COVID-19, including those free of symptoms, exhibited "significant cognitive deficits."
"When we first saw the results, we were quite alarmed..."
Reimer calls findings from COVID fog study 'alarming'
1 in 4 post-Covid have cognitive dysfunction: "...has persistent concentration difficulties, has problems with verbal or non-verbal learning, has short-term or working memory loss, & many other symptoms related to the brain"
'They can’t think': Covid patients suffer memory problems months after recovering
As many as 24% of people who have recovered from Covid-19 continue to experience cognitive difficulties, including problems w/memory, multitasking, processing speed & focusing, researchers at the Icahn School of Medicine at Mount Sinai reported Friday:
COVID-19-related encephalopathy presenting with aphasia resolving following tocilizumab treatment
"COVID-19-related encephalopathy may present with early language disturbances.
Cytokine-mediated neuroinflammation has been suggested as the underlying mechanism"
COVID-19-related encephalopathy presenting with aphasia:
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Life as a Long-Hauler: COVID Leaves Former English Professor at a Loss for Words
"This condition is called speech aphasia ...it’s being increasingly detected in Covid long-haulers like Heidenberg, including those who weren’t hospitalized."
Encephalopathy in COVID-19 Presenting With Acute Aphasia Mimicking Stroke
"reversible COVID-19-related encephalopathy presenting as acute aphasia, mimicking stroke or status epilepticus, eventually evolving into delirium...our case suggests that focal neurological deficits may occur as the earliest feature of encephalopathy"
laurie allee on Twitter
Starting thread on aphasia as related to Covid19
COVID-19 and Aphasia
"evidence of neurological and dysexecutive syndromes subsequent to interference of brain functions in acute patients with COVID-19, leading to variable aphasia-like symptoms."
laurie allee on Twitter
Read this thread. Any Covid infection can lead to Alzheimer’s-like brain damage.
There will be no herd immunity. Reinfection happens on average in 16 mos.
We also know it causes organ damage, clots & T-cell decrease.
We’ve barely begun to see what Covid infection means long term.
COVID-19 survivors may suffer from loss of gray matter over time: study
Gray matter is part of our central nervous system & essentially controls ALL our brain's functions...It enables us to control movement, memory, & emotions, so an abnormality in the gray matter of the brain can affect communication skills & brain cells.
Study links even mild Covid-19 to changes in the brain | CNN
"People who have even a mild case of Covid-19 may have accelerated aging of the brain and other changes to it...the brains of those who had Covid-19 had a greater loss of gray matter and abnormalities in the brain tissue compared with those who didn't:"
Even Mild Cases of COVID May Leave a Mark on the Brain
Team saw marked differences in gray matter between those who had gotten /COVID-19 & those who hadn't. Thickness of gray matter in frontal & temporal lobes was reduced in COVID-19 group, differing from typical patterns seen those that hadn’t had COVID-19.
laurie allee on Twitter
"A recent Nature study of 785 people ages 51 to 81 found those who had COVID-19 lost more grey matter and had more brain shrinkage than those who had not."