NYC man's fatal brain disease linked to COVID-19: 'Highly likely'
“Doctors from Mount Sinai Queens’ said it’s ‘highly likely’ COVID contributed to a New York City man developing fatal prion disease.”
Acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization
“we identified two distinct biomarker profiles measured during the acute admission, which predict cognitive outcomes 6 and 12 months after COVID-19.”
Severe acute respiratory syndrome coronavirus 2 infection leads to Tau pathological signature in neurons
“It is now evident that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection results in a wide range of long-term neurological symptoms and is worryingly associated with the aggravation of Alzheimer’s disease. Little is known about the molecular basis of these manifestations.”
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importance of neuropsychology in the early rehabilitation of patients with critical illness after acute COVID infection
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Neurological damages in COVID‐19 patients: Mechanisms and preventive interventions
Brain Pathology in COVID-19: Clinical Manifestations and Potential Mechanisms
Even though Omicron caused less severe disease than Delta, the incidence of neurological manifestations is similar. More than 30% of patients experienced 'brain fog', delirium, stroke, and cognitive impairment, and over half of these patients presented abnormal neuroimaging outcomes.. The most frequent imaging features (affecting >60% of patients) include ischemic infarcts, intracerebral hemorrhages, perfusion abnormalities, and leptomeningeal enhancement. Hypometabolism in the pons, cerebellum, bilateral insula, bilateral medial lobes, and prefrontal cortex indicates brain function dysregulation in COVID patients. The high incidence of cerebrovascular events such as ischemic stroke and intracerebral hemorrhage, indicates potential endothelial injury and coagulation dysfunction. Other investigations have also reported hypoxic alterations in the cerebellum and cerebrum, metabolic alterations of astrocytes, microglial activation, neuro-axonal damage, and neuronal loss.."
Alix Burack on Twitter
related:
Neuroinflammation After COVID-19 With Persistent Depressive and Cognitive Symptoms
Neuroinflammation After COVID-19 With Persistent Depressive and Cognitive Symptoms
Wes Wilson on Twitter
Study from CAMH found, via PET scans, elevated levels of the protein TSPO, a brain marker of inflammation, in patients with onset of depression in long covid
more than 200 million globally may experience lingering neurological symptoms from COVID, including depression, memory impairment, slower motor control, low motivation and energy, for months to even years due to brain inflammation from long COVID
this along side everything we have learned in the last 2.5 years ( much summarized in the lit review done by Stanford and Yale, linked in the comments ) moves us a step closer in understanding the underlying biological mechanisms behind these symptoms
The negative impact of COVID-19 on working memory revealed using a rapid online quiz
“Memory scores for all COVID groups combined were significantly reduced compared to the non-COVID group in every age category 25 years and over...”
Dutch Survey Data Shows Significant Increase In Memory And Concentration Problems Among Adults Since Start Of Covid-19 Pandemic
"Dutch Survey Data Shows Significant Increase In Memory And Concentration Problems Among Adults Since Start Of Covid-19 Pandemic"
CAMH study confirms ongoing brain inflammation associated with long COVID
"What’s new about this study is that it shows that inflammation is hanging around for a long time in the brains of people with long COVID even after only mild to moderate symptoms of active COVID-19,”
Nate Bear on Twitter
Thread on Twitter: New study documents the case of two previously healthy sisters - 11 and 13-years-old - with new-onset cognitive decline after mild covid. The ability of their brains to consume glucose had been impaired - an initiating factor for dementia, Parkinson's and Alzheimer's disease 🧵
Does COVID-19 damage the brain? - Harvard Health
"Even if people escape brain damage during the initial attack of COVID-19, they remain at considerably greater risk of various brain conditions, including strokes, depression, anxiety, and psychosis for the next several years."
Brain hypoxia, neurocognitive impairment, and quality of life in people post-COVID-19
"We report that there was brain hypoxia in approximately 24% of individuals who were at least 8 weeks post-COVID-19 infection, despite normal arterial saturation and no signs of fever."
Unmasking Long COVID: How SARS-CoV-2 Plays Mind Tricks With Your Pain
"study...has revealed that SARS-CoV-2 infection can lead to lasting damage to the dorsal root ganglia, resulting in Post-COVID Conditions or Long COVID..."
Harry Spoelstra on Twitter
Interesting study: Inflammatory and mental health sequelae of COVID-19
"The COVID-19 pandemic has caused significant negative consequences to mental health. Increased inflammatory factors and neuropsychiatric symptoms, such as cognitive impairment (“brain fog”), depression, and anxiety are associated with long COVID [post-acute sequelae of SARS-CoV-2 infection (PASC), termed neuro-PASC]"
➡️Biomarker: MIG
"Growing evidence supporting the usefulness of circulating MIG(monokine induced by gamma interferon (IFN-γ) aka CXCL9) levels as a biomarker reflecting IFN-γ production, which is important because individuals with neuro-#PASC/ neuro-#Longcovid have elevated IFN-γ responses to internal SARS-CoV-2 proteins"
Study: COVID-19 Can Accelerate Brain Aging, Lead to Irreversible Neurological Conditions
“Tiny leakages of blood in crucial brain regions of patients infected with Covid-19 can accelerate brain aging and lead to irreversible neurodegenerative conditions, according to a Houston Methodist review study.”
Study found long-term brain damage associated with COVID-19, not vaccine | Fact check
"We have done zero experiments using the vaccine, and we have shown and claim zero side effects of the vaccine...Our work reports the presence of the spike protein in the skull of deceased individuals long after their COVID-19 infection"
laurie allee on Twitter
"This comprehensive analysis of patients with neuro-PASC revealed a disabling but difficult to characterize syndrome that develops even after relatively mild COVID-19. A common feature is memory impairment."
COVID-19 could put us at a greater risk of neurodegenerative diseases and stroke
"Analysis of nearly one million Danish health records has found patients who tested positive for COVID-19 were subsequently more likely to be diagnosed with Alzheimer’s disease, Parkinson’s disease and stroke."
'I thought my daughter had brain fog from long Covid but it was dementia'
Long COVID and Dementia: The Link Is Still Elusive | ALZFORUM
154,000 veterans who had COVID were 1.4 times likelier to have a neurologic condition--memory problems, stroke, neuropathy, mental health disorders, migraines, or seizures--in year following illness. This was true for all COVID cases, from mild to severe.
Millions of people have long COVID brain fog — and there's a shortage of answers
"COVID. That, too, can basically be a cause of a brain injury."
The ‘Brain Fog’ of Long COVID Is a Serious Medical Issue That Needs More Attention
"new research has shown that long COVID can result in neurological damage and neurocognitive dysfunction that may cause lifelong impairment."
One-two punch from pair of common viruses may trigger Alzheimer’s disease
Related: "potential future Alzheimer’s problems may arise from the COVID-19 pandemic as SARS-CoV-2 infections have been known to reactivate dormant VSV and HSV-1 infections...the pandemic could increase future rates of neurodegenerative disease"
Selective Neuronal Mitochondrial Targeting in SARS-CoV-2 Infection Affects Cognitive Processes to Induce ‘Brain Fog’ and Results in Behavioral Changes that Favor Viral Survival
"Selective Neuronal Mitochondrial Targeting in SARS-CoV-2 Infection Affects Cognitive Processes to Induce ‘Brain Fog’ and Results in Behavioral Changes that Favor Viral Survival"
Could long covid change brain activity
"Scientists report that brain scans of long COVID patients show abnormal activity in areas related to memory...likened the brain changes to what happens in HIV patients and in those with traumatic brain injury."
Long-COVID patients show abnormal brain activity on MRI while doing memory tasks
"Long-COVID patients with neuropsychiatric symptoms such as brain fog showed abnormal brain activity on magnetic resonance imaging (MRI) while completing memory tests,"
Post-COVID-19 Brain [18F] FDG-PET Findings: A Retrospective Single-Center Study in the United States
"patients with a history of COVID-19 infection exhibited focal areas of hypometabolism in the bilateral frontal, parietal, occipital, and posterior temporal lobes and cerebellum"