Unmasking Long COVID: How SARS-CoV-2 Plays Mind Tricks With Your Pain
"study...has revealed that SARS-CoV-2 infection can lead to lasting damage to the dorsal root ganglia, resulting in Post-COVID Conditions or Long COVID..."
Harry Spoelstra on Twitter
Interesting study: Inflammatory and mental health sequelae of COVID-19
"The COVID-19 pandemic has caused significant negative consequences to mental health. Increased inflammatory factors and neuropsychiatric symptoms, such as cognitive impairment (“brain fog”), depression, and anxiety are associated with long COVID [post-acute sequelae of SARS-CoV-2 infection (PASC), termed neuro-PASC]"
➡️Biomarker: MIG
"Growing evidence supporting the usefulness of circulating MIG(monokine induced by gamma interferon (IFN-γ) aka CXCL9) levels as a biomarker reflecting IFN-γ production, which is important because individuals with neuro-#PASC/ neuro-#Longcovid have elevated IFN-γ responses to internal SARS-CoV-2 proteins"
Study: COVID-19 Can Accelerate Brain Aging, Lead to Irreversible Neurological Conditions
“Tiny leakages of blood in crucial brain regions of patients infected with Covid-19 can accelerate brain aging and lead to irreversible neurodegenerative conditions, according to a Houston Methodist review study.”
Study found long-term brain damage associated with COVID-19, not vaccine | Fact check
"We have done zero experiments using the vaccine, and we have shown and claim zero side effects of the vaccine...Our work reports the presence of the spike protein in the skull of deceased individuals long after their COVID-19 infection"
laurie allee on Twitter
"This comprehensive analysis of patients with neuro-PASC revealed a disabling but difficult to characterize syndrome that develops even after relatively mild COVID-19. A common feature is memory impairment."
COVID-19 could put us at a greater risk of neurodegenerative diseases and stroke
"Analysis of nearly one million Danish health records has found patients who tested positive for COVID-19 were subsequently more likely to be diagnosed with Alzheimer’s disease, Parkinson’s disease and stroke."
'I thought my daughter had brain fog from long Covid but it was dementia'
Long COVID and Dementia: The Link Is Still Elusive | ALZFORUM
154,000 veterans who had COVID were 1.4 times likelier to have a neurologic condition--memory problems, stroke, neuropathy, mental health disorders, migraines, or seizures--in year following illness. This was true for all COVID cases, from mild to severe.
Millions of people have long COVID brain fog — and there's a shortage of answers
"COVID. That, too, can basically be a cause of a brain injury."
The ‘Brain Fog’ of Long COVID Is a Serious Medical Issue That Needs More Attention
"new research has shown that long COVID can result in neurological damage and neurocognitive dysfunction that may cause lifelong impairment."
One-two punch from pair of common viruses may trigger Alzheimer’s disease
Related: "potential future Alzheimer’s problems may arise from the COVID-19 pandemic as SARS-CoV-2 infections have been known to reactivate dormant VSV and HSV-1 infections...the pandemic could increase future rates of neurodegenerative disease"
Selective Neuronal Mitochondrial Targeting in SARS-CoV-2 Infection Affects Cognitive Processes to Induce ‘Brain Fog’ and Results in Behavioral Changes that Favor Viral Survival
"Selective Neuronal Mitochondrial Targeting in SARS-CoV-2 Infection Affects Cognitive Processes to Induce ‘Brain Fog’ and Results in Behavioral Changes that Favor Viral Survival"
Could long covid change brain activity
"Scientists report that brain scans of long COVID patients show abnormal activity in areas related to memory...likened the brain changes to what happens in HIV patients and in those with traumatic brain injury."
Long-COVID patients show abnormal brain activity on MRI while doing memory tasks
"Long-COVID patients with neuropsychiatric symptoms such as brain fog showed abnormal brain activity on magnetic resonance imaging (MRI) while completing memory tests,"
Post-COVID-19 Brain [18F] FDG-PET Findings: A Retrospective Single-Center Study in the United States
"patients with a history of COVID-19 infection exhibited focal areas of hypometabolism in the bilateral frontal, parietal, occipital, and posterior temporal lobes and cerebellum"
laurie allee on Twitter
Starting thread on Covid as a potential prion
Creutzfeldt-Jakob disease in a man with COVID-19: SARS-CoV-2-accelerated neurodegeneration? - PubMed
Related: "Drawing from recent data on prion disease pathogenesis and immune responses to SARS-CoV-2, we hypothesize that the cascade of systemic inflammatory mediators in response to the virus accelerated the pathogenesis of our patient's prion disease."
Prion-like domains in SARS-CoV-2 RBD and ACE2 play important functional roles in viral adhesion and entry
"The findings of this research are in line with previous studies that analyzed the pathological function of prions in humans"
SARS-CoV-2, long COVID, prion disease and neurodegeneration
SARS-CoV-2, long COVID, prion disease and neurodegeneration
Chris Turnbull on Twitter
Comprehensive thread on possible prion involvement with SarsCov2 Mad Cov-Disease? New study looks at the possibility that Covid is a prion (a type of protein that can cause degenerative brain diseases such as Creutzfeldt-Jakob disease (CJD) aka mad Cow disease
Is Long Covid a prion disease?
Potential Prion Involvement in Long COVID-19 Neuropathology, Including Behavior
"Potential Prion Involvement in Long COVID-19 Neuropathology, Including Behavior"
UCSD Scientists Find COVID Damages Brain Cell Synapses, But Propose Treatment
“an FDA-approved antiviral drug might be repurposed to restore infected brain cells to health.. sofosbuvir — already an approved treatment for hepatitis C – – effectively inhibited SARS-CoV-2 replication and reversed damages in infected brain organoids.”
Cognitive impairment in young adults with post COVID-19 syndrome
Covid cognitive impairment in young adults: concentration difficulties (87.85%), anomia/word-finding difficulties in speech (86.44%), processing speed/remembering recent events (76.16%), multitasking (75.23%) reading aloud/reading comprehension (69.62%).
Study: Parts of COVID-19 may stay in brain long after infection
"A recent study found parts of the COVID-19 virus may remain in the brain long after a person has recuperated from the infection."
Effects of post-acute COVID-19 syndrome on the functional brain networks of non-hospitalized individuals
"...physiological recovery from COVID-19 may extend well beyond the resolution of acute symptoms, with the persistence of post-COVID brain changes raising particular concerns about the cumulative effects of repeated infection on brain function"
Canadian neurocognitive disorder expert speaks to Global Workers Inquest into the Pandemic: “To say ‘they are old, they can die’—it’s criminal”
"The impact I am seeing on my clients post-COVID is something I hadn’t seen previously in the years I have worked in this field. The cognitive decline post-COVID infection is immense, thus confirming the impact this virus has on the brain..."
Mild Covid infection can shrink brain by up to 2%, reveals study | Hyderabad News - Times of India
Mild Covid infection can shrink brain by up to 2%
COVID-19 Strikes Again: Accelerating Dementia in the Most Vulnerable
"A study published in the Journal of Alzheimer’s Disease Reports reveals that infection with SARS-CoV-2 significantly impacts cognitive function in patients with preexisting dementia, causing rapidly progressive dementia."
Had COVID? Part of the Virus May Stick Around in Your Brain
"Had COVID? Part of the Virus May Stick Around in Your Brain
Researchers in Germany found that part of the virus, the spike protein, remains in the brain long after the virus clears out..."
Cerebral hypoperfusion in post-COVID-19 cognitively impaired subjects revealed by arterial spin labeling MRI
New paper comparing #LongCovid patients to matched controls found significantly reduced blood flow all over the brain - frontal, temporal, & parietal lobes.
Middle column in the picture below are healthy controls; red/warm colors = more blood flow. 1/