COVID-19 & Carcinogenesis:
The relationship between COVID-19 and cancer development is a complex interaction of immune suppression, chronic inflammation, genetic and epigenetic changes, and possible direct viral effects.
Disturbing trends: Rampant COVID-19 increases deaths from the pre-pandemic baseline.
'Disentangling the relationship between cancer mortality and COVID-19 in the US'
“The Kralls are among a growing number of people who had COVID and then developed rare kinds of cancer, often more than one kind.
‘We started noticing some very unusual patterns,’ said the Kralls’ physician, Dr. Kashyap Patel. He and his colleagues at Carolina Blood and Cancer Care Associates have documented some very concerning links between COVID and cancer”
SARS-CoV-2 down-regulates p53 cancer suppressor gene expression for at least 6 months.
I don’t even want to think about what repeated infections every few months could do to the cancer rate.
Yet another reason to avoid infection. #BringBackMasks
“Our findings suggest that SARS-CoV-2 can be considered a potential risk factor for increasing the probability of developing cancer.”
💥💥💥💥💥💥💥💥💥
Told you it was ONCOGENIC!!!!!!!!!!!!!!!!!!!!
Long AGO!!!!!!!!!!!!!!!!!!!!!!!!
A hard but necessary read for scientists and policy makers | cancer as a perspective sequelae of #LongCovid. We know already viruses like EBV (Epstein Barr) are triggers or drivers of many kinds of cancers. Would SARS-CoV-2 be any different?
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Can a COVID-19 Infection Increase Your Risk of Developing Leukemia? “It’s plausible that Covid-19 could predispose your body to cancer and accelerate cancer progression.”
Related: “As CMV meddles in those processes for its own ends, it could be disrupting our body’s ability to repair its own DNA as it interacts with our cells over decades. When we lose the stability of our own genome, ‘that’s when cancer occurs.’”
Some viruses are cancer-causing ("oncogenic"). HPV and anogenital and head and neck cancers, Hepatitis B and C viruses and liver cancer; Epstein Barr virus and lymphomas etc…
I'd be surprised if SARS-CoV-2 doesn't join the list.
“EBV is found in the bone marrow of 90% of people, CMV in 60% of people and herpes simplex in 50% of individuals in the dormant state. Herpes and CMV are found in various body parts.”
This seems important.
T cells die and get depleted
If you dysregulate this you can get things like lymphoproliferation or cancers with too little death, and depletion with too much
Don't annoy me with people in denial about T cell death signatures
The findings are robust in Covid-19
What if Covid leads to cancer later? What will we do when we already infected everyone?
Perhaps that’s why mass infection with a novel virus isn’t advisable. Some countries understand this aspect, and some countries don’t.