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Characteristic immune cell interactions in livers of children with acute hepatitis revealed by spatial single-cell analysis identify a possible postacute sequel of COVID-19
Characteristic immune cell interactions in livers of children with acute hepatitis revealed by spatial single-cell analysis identify a possible postacute sequel of COVID-19
"We identified a possible manifestation of an immune-mediated postacute sequel to COVID-19 associated with a characteristic immune infiltrate in children with AHUO. COVID-19 testing should be considered in paediatric AHUO"
#Immune dysregulation#Immune system#Kids#Liver#Post-Acute Conditions#hepatitis#inflammation
·gut.bmj.com·
Characteristic immune cell interactions in livers of children with acute hepatitis revealed by spatial single-cell analysis identify a possible postacute sequel of COVID-19
Characteristic immune cell interactions in livers of children with acute hepatitis revealed by spatial single-cell analysis identify a possible postacute sequel of COVID-19 | Gut
Characteristic immune cell interactions in livers of children with acute hepatitis revealed by spatial single-cell analysis identify a possible postacute sequel of COVID-19 | Gut

In a new study, children developed acute hepatitis around 2 months after COVID-19 infection.

They tested negative for acute COVID via PCR, but their livers told a different story.

SARS-CoV-2 proteins were still hiding inside, and their immune systems were trying to fight back.

Autoimmune response:

#hepatitis#Kids#Liver#Immune system#inflammation#young people#Post-Acute Conditions#Immune dysregulation#opportunistic infections#autoimmune#Autoimmune Diseases#autoimmunity#Immune Deficiency
·gut.bmj.com·
Characteristic immune cell interactions in livers of children with acute hepatitis revealed by spatial single-cell analysis identify a possible postacute sequel of COVID-19 | Gut
laurie allee on Twitter
laurie allee on Twitter
"Covid-19 induced hepatitis (CIH), definition and diagnostic criteria of a poorly understood new clinical syndrome"
#Liver#hepatitis
·twitter.com·
laurie allee on Twitter
Chronic hepatitis-C infection in COVID-19 patients is associated with in-hospital mortality - PubMed
Chronic hepatitis-C infection in COVID-19 patients is associated with in-hospital mortality - PubMed

Covid and Hepatitis C: "...history of HCV infection leads to an accentuated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virulence, irrespective of baseline comorbidities, admission laboratory variables, or COVID-19-induced liver injury"

#Liver#hepatitis
·pubmed.ncbi.nlm.nih.gov·
Chronic hepatitis-C infection in COVID-19 patients is associated with in-hospital mortality - PubMed
Pmc7927974
Pmc7927974
Case study: COVID-19 infection with hepatitis B co-infection "fever, catarrh, headaches, fatigue, and loss of smell...history of chronic hepatitis B infection which appeared to be inactive given a history of normal outpatient liver tests prior to Covid..."
#Liver#hepatitis
·ncbi.nlm.nih.gov·
Pmc7927974
2022
2022
preprint finds that a #SARSCoV2 variant mimics human liver protein that may trigger T-cell autoimmunity—thus might damage the liver. Authors suggest it could explain a surge in children hepatitis. Note: ORF-1 protein is not found in vaccines.
#autoimmune#T-cells#Liver#hepatitis#Kids
·biorxiv.org·
2022
Raina MacIntyre 😷💉💉💉💉 on Twitter
Raina MacIntyre 😷💉💉💉💉 on Twitter

Twitter thread: Let's talk about the mystery epidemic of #hepatitis in children. It's most likely a complication of #COVID19 but may take a while to be adjudicated as such. The syndrome has been seen in children <17, mostly unvaccinated kids <5 years. A thread.

#Liver#Kids#hepatitis
·twitter.com·
Raina MacIntyre 😷💉💉💉💉 on Twitter