“Quick 🧵on the current state of Iota-carrageenan nasal sprays: Efficacy, safety, Betadine shortages, buying options for US & Can. markets.

I-C sprays are the only option on the market that have a real-world randomized, double-blind, placebo-controlled study backing them up. 1/14”

“Current nasal sprays offer limited protection against respiratory pathogens because they have a single mechanism of protection. They either neutralize pathogens or block their entry into the cells lining the nose, and they perform both tasks with limited efficacy.

‘We developed a drug-free formulation to block germs in three ways — the spray forms a gel-like matrix that enhances the capture of respiratory droplets, immobilizes the germs blocking their transport into the nasal lining, and effectively neutralizes them, preventing infection,’”

New, promising data on Profi Nasal Spray (aka PCANS) as prophylaxis for respiratory viruses:

“The researchers developed the formulation and studied its ability to capture respiratory droplets in a 3D-printed replica of a human nose. They showed that when sprayed in the nasal cavity replica, PCANS captured twice as many droplets as mucus alone.

April, 2023:

"These results show a potentially more rapid route to FDA approval, bringing a new commercial opportunity that could make the nasal sprays more readily available...not just potentially for COVID-19, but also for all respiratory viruses"

"Simple pH adjustment may enable a preventative Covid-19 nasal and throat spray

Higher pH makes a common metabolic inhibitor medication practical for nose and throat spray applications against COVID-19"

Starting thread on niclosamide:

"These researchers developed a prophylactic nasal spray and early treatment throat spray by repurposing niclosamide, a metabolic inhibitor previously used for 60 years for gut parasite infections." https://dukechronicle.com/article/2022/03/duke-university-scientist-coronavirus-covid-treatment-nasal-spray#:~:text=Niclosamide%20works%20by%20blocking%20three%20of%20the%20six,said.%20Formerly%2C%20niclosamide%20was%20FDA-approved%20in%20pill%20form.