Covid and Pregnancy

Covid and Pregnancy

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Neurodevelopmental delay in children exposed to maternal SARS-CoV-2 in-utero
Neurodevelopmental delay in children exposed to maternal SARS-CoV-2 in-utero

From a comparative study in USA and Brazil on the neurodevelopment in children born to mothers infected with SARS-CoV-2 during pregnancy, "results demonstrated that 12 of 128 exposed children (9.4%) had DD (developmental delay) versus 2 of 128 controls (1.6%). Eight of 44 additional exposed children had DD on ASQ-3 testing.. 20 of 172 exposed children (11.6%) and 2 of 128 control children (1.6%) had DD. In Rio, 12% of exposed children versus 2.6% of controls had DD. In LA, 5.7% of exposed children versus 0 controls had DD. Severe/critical maternal COVID-19 predicted below average neurodevelopment in the exposed cohort (OR 2.6). Children exposed to antenatal COVID-19 have a tenfold higher frequency of developmental delay as compared to controls.."

·nature.com·
Neurodevelopmental delay in children exposed to maternal SARS-CoV-2 in-utero
The COVID-19 Pandemic Period, SARS-CoV-2 Infection, and Perinatal Health
The COVID-19 Pandemic Period, SARS-CoV-2 Infection, and Perinatal Health
“connections of COVID-19 with adverse perinatal outcomes have been documented in large population studies and meta-analyses,”
connections of COVID-19 with adverse perinatal outcomes have been documented in large population studies and meta-analyses,
·jamanetwork.com·
The COVID-19 Pandemic Period, SARS-CoV-2 Infection, and Perinatal Health
TACT on Twitter
TACT on Twitter

Detailed analysis thread on Twitter Volume 43, Issue 5, September–October 2022

All newborns whose mothers had COVID during pregnancy should be evaluated for hearing loss, according to this study. "The Hearing Loss in newborns caused by maternal SARS-CoV-2 infection is still not fully understood. Therefore, prospective, large-scale clinical studies need to be conducted in the future."

·twitter.com·
TACT on Twitter
Janic Feth on Twitter
Janic Feth on Twitter

Anecdote This is what I’ve been saying. We are tracking multiple poor outcomes at work in our referrals to Infant Development for babies born to mothers who had COVID during pregnancy. Our biggest concerns stem from infection after 20 weeks gestation. This includes increased admissions to NICU immediately after birth, but also increased global developmental delays. It absolutely stands to reason that they are also then at increased risk for more severe outcomes when sick.

·twitter.com·
Janic Feth on Twitter
Covid-19 And Preeclampsia
Covid-19 And Preeclampsia
"INTERCOVID study... pregnant individuals with COVID-19 had almost two-fold higher risk of preeclampsia, as well as other adverse outcomes including maternal mortality, severe infection, and preterm birth compared to pregnant individuals without COVID-19."
·preeclampsia.org·
Covid-19 And Preeclampsia
SARS CoV-2 detected in neonatal stool remote from maternal COVID-19 during pregnancy
SARS CoV-2 detected in neonatal stool remote from maternal COVID-19 during pregnancy

SARS CoV-2 detected in neonatal stool remote from maternal COVID-19 during pregnancy "Despite negative SARS CoV-2 nasal PCRs from all newborns, viral RNAs and Spike protein were detected in the stool of 11 out of 14 newborns as early as the first day of life and increased over time in 6."

·nature.com·
SARS CoV-2 detected in neonatal stool remote from maternal COVID-19 during pregnancy
Roland Baker on Twitter
Roland Baker on Twitter

Detailed analysis JAMA: Neurodevelopmental Outcomes at 1 Year in Infants of Mothers Who Tested Positive for SARS-CoV-2 During Pregnancy: were more likely to receive a neurodevelopmental diagnosis in the first 12 months after delivery even accounting for preterm delivery.

·twitter.com·
Roland Baker on Twitter
Mrs Marzipan on Twitter
Mrs Marzipan on Twitter

Analysis thread on Twitter Placental abnormalities in #SarsCov19 infection were associated with significant higher incidence of unexplained stillbirths, and lower Apgar scores.

The placental pathology in #Covid19 infected mothers and its impact on pregnancy outcome…

#COVIDinpregnancy #CovidIsNotOver

·twitter.com·
Mrs Marzipan on Twitter
Fulltext
Fulltext
In pregnant women who tested positive for SARS-CoV-2, normalised fetal lung volume was significantly reduced compared with age-adjusted reference values,4 in the absence of structural abnormalities or organ infarction, and was unexplained by differences in somatic growth (84% vs 24% of 50th percentile reference; p<0·0001; figure). The timepoint of infection showed significant effects on fetal lung growth, with reduced lung volumes observed with SARS-CoV-2 infections acquired during the third trimester (69% vs 91% of 50th percentile reference in the first or second trimester;
·thelancet.com·
Fulltext