Study in Catania, Italy, analyzed cranial ultrasounds of 278 newborns, 139 exposed to SARS-CoV-2 during pregnancy.
Exposed newborns had higher rates of minor brain abnormalities (23% vs 16.5%).
“Conclusions
in our experience, the incidence of minor intracranial abnormalities was higher in SARS-COV-2-exposed newborns.”
“COVID study reveals virus-induced inflammation during pregnancy, redefines vertical transmission A protein made by SARS-CoV-2 can pass through the placenta and cause serious inflammatory immune responses in the fetus for 66% of pregnancies.”
“New research is shedding light on what happens when a person becomes sick with COVID-19 during pregnancy. Our study finds a protein from the virus can pass through the placenta and cause serious inflammation.”
Study at UC Davis on 10 infants born to COVID-19 positive mothers found fecal shedding of the virus in 4 infants, even with negative nasal swabs.
Fecal shedding was linked to changes in the gut microbiome.
From a comparative study in USA and Brazil on the neurodevelopment in children born to mothers infected with SARS-CoV-2 during pregnancy, "results demonstrated that 12 of 128 exposed children (9.4%) had DD (developmental delay) versus 2 of 128 controls (1.6%). Eight of 44 additional exposed children had DD on ASQ-3 testing.. 20 of 172 exposed children (11.6%) and 2 of 128 control children (1.6%) had DD. In Rio, 12% of exposed children versus 2.6% of controls had DD. In LA, 5.7% of exposed children versus 0 controls had DD. Severe/critical maternal COVID-19 predicted below average neurodevelopment in the exposed cohort (OR 2.6). Children exposed to antenatal COVID-19 have a tenfold higher frequency of developmental delay as compared to controls.."
“Pregnant women with Covid face a sevenfold risk of dying compared with uninfected pregnant women…. The infection also makes it more likely that a woman will give birth prematurely and that the baby will require neonatal intensive care”
Detailed analysis thread with commentary Sars2/Covid:new study shows that the fetuses of those infected with virus have significant 'organ abnormalities' including brain lesions and liver 'alterations'
-Fetuses also found to have significantly restricted growth
-Virus infects placenta directly
Detailed analysis thread on Twitter Volume 43, Issue 5, September–October 2022
All newborns whose mothers had COVID during pregnancy should be evaluated for hearing loss, according to this study. "The Hearing Loss in newborns caused by maternal SARS-CoV-2 infection is still not fully understood. Therefore, prospective, large-scale clinical studies need to be conducted in the future."
Detailed analysis thread This is absolutely catastrophic placental failure from a condition called SARS-CoV-2-related histiocytic intervillositis. In other words, #CovidPlacenta 😔 1/ #GetVaccinatedInPregnancy #PathTwitter
Anecdote This is what I’ve been saying. We are tracking multiple poor outcomes at work in our referrals to Infant Development for babies born to mothers who had COVID during pregnancy. Our biggest concerns stem from infection after 20 weeks gestation. This includes increased admissions to NICU immediately after birth, but also increased global developmental delays. It absolutely stands to reason that they are also then at increased risk for more severe outcomes when sick.
![Fecal shedding of SARS-CoV-2 in infants born to SARS-CoV-2 positive mothers: a pilot study [PeerJ]](https://rdl.ink/render/https%3A%2F%2Fdfzljdn9uc3pi.cloudfront.net%2F2024%2F17956%2F1%2Ffig-2-1x.jpg?width=350&height=&ar=16:9&mode=crop&format=avif&dpr=2)
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