Study in Catania, Italy, analyzed cranial ultrasounds of 278 newborns, 139 exposed to SARS-CoV-2 during pregnancy.
Exposed newborns had higher rates of minor brain abnormalities (23% vs 16.5%).
“Conclusions
in our experience, the incidence of minor intracranial abnormalities was higher in SARS-COV-2-exposed newborns.”
Study at UC Davis on 10 infants born to COVID-19 positive mothers found fecal shedding of the virus in 4 infants, even with negative nasal swabs.
Fecal shedding was linked to changes in the gut microbiome.
Detailed analysis thread on Twitter Volume 43, Issue 5, September–October 2022
All newborns whose mothers had COVID during pregnancy should be evaluated for hearing loss, according to this study. "The Hearing Loss in newborns caused by maternal SARS-CoV-2 infection is still not fully understood. Therefore, prospective, large-scale clinical studies need to be conducted in the future."
Anecdote This is what I’ve been saying. We are tracking multiple poor outcomes at work in our referrals to Infant Development for babies born to mothers who had COVID during pregnancy. Our biggest concerns stem from infection after 20 weeks gestation. This includes increased admissions to NICU immediately after birth, but also increased global developmental delays. It absolutely stands to reason that they are also then at increased risk for more severe outcomes when sick.
SARS CoV-2 detected in neonatal stool remote from maternal COVID-19 during pregnancy "Despite negative SARS CoV-2 nasal PCRs from all newborns, viral RNAs and Spike protein were detected in the stool of 11 out of 14 newborns as early as the first day of life and increased over time in 6."
Detailed analysis JAMA: Neurodevelopmental Outcomes at 1 Year in Infants of Mothers Who Tested Positive for SARS-CoV-2 During Pregnancy: were more likely to receive a neurodevelopmental diagnosis in the first 12 months after delivery even accounting for preterm delivery.
![Fecal shedding of SARS-CoV-2 in infants born to SARS-CoV-2 positive mothers: a pilot study [PeerJ]](https://rdl.ink/render/https%3A%2F%2Fdfzljdn9uc3pi.cloudfront.net%2F2024%2F17956%2F1%2Ffig-2-1x.jpg?width=350&height=&ar=16:9&mode=crop&format=avif&dpr=2)
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