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Maternal COVID-19 infection associated with offspring neurodevelopmental disorders
Maternal COVID-19 infection associated with offspring neurodevelopmental disorders
“Maternal COVID-19 infection changed the levels of CD4 proliferating T cells, leading to the alterations of astrocytes, endothelial cells, and excitatory neurons in offspring, contributing to the increased risk of neurodevelopmental disorders (NDDs) in these individuals."
·nature.com·
Maternal COVID-19 infection associated with offspring neurodevelopmental disorders
Neuronal progenitors of the dentate gyrus express the SARS-CoV-2 cell receptor during migration in the developing human hippocampus
Neuronal progenitors of the dentate gyrus express the SARS-CoV-2 cell receptor during migration in the developing human hippocampus
There’s a limited pool of neural stem cells below the hippocampus that gradually gets used up for memory consolidation throughout your life. In depression, they aren’t turning into neurons fast enough with disastrous consequences; SSRIs speed that back up. In schizophrenia, -
·ncbi.nlm.nih.gov·
Neuronal progenitors of the dentate gyrus express the SARS-CoV-2 cell receptor during migration in the developing human hippocampus
Janic Feth on Twitter
Janic Feth on Twitter

Anecdote This is what I’ve been saying. We are tracking multiple poor outcomes at work in our referrals to Infant Development for babies born to mothers who had COVID during pregnancy. Our biggest concerns stem from infection after 20 weeks gestation. This includes increased admissions to NICU immediately after birth, but also increased global developmental delays. It absolutely stands to reason that they are also then at increased risk for more severe outcomes when sick.

·twitter.com·
Janic Feth on Twitter
Roland Baker on Twitter
Roland Baker on Twitter

Detailed analysis JAMA: Neurodevelopmental Outcomes at 1 Year in Infants of Mothers Who Tested Positive for SARS-CoV-2 During Pregnancy: were more likely to receive a neurodevelopmental diagnosis in the first 12 months after delivery even accounting for preterm delivery.

·twitter.com·
Roland Baker on Twitter