Detailed analysis thread This is absolutely catastrophic placental failure from a condition called SARS-CoV-2-related histiocytic intervillositis. In other words, #CovidPlacenta 😔 1/ #GetVaccinatedInPregnancy #PathTwitter
Anecdote This is what I’ve been saying. We are tracking multiple poor outcomes at work in our referrals to Infant Development for babies born to mothers who had COVID during pregnancy. Our biggest concerns stem from infection after 20 weeks gestation. This includes increased admissions to NICU immediately after birth, but also increased global developmental delays. It absolutely stands to reason that they are also then at increased risk for more severe outcomes when sick.
SARS CoV-2 detected in neonatal stool remote from maternal COVID-19 during pregnancy "Despite negative SARS CoV-2 nasal PCRs from all newborns, viral RNAs and Spike protein were detected in the stool of 11 out of 14 newborns as early as the first day of life and increased over time in 6."
Detailed analysis JAMA: Neurodevelopmental Outcomes at 1 Year in Infants of Mothers Who Tested Positive for SARS-CoV-2 During Pregnancy: were more likely to receive a neurodevelopmental diagnosis in the first 12 months after delivery even accounting for preterm delivery.
Analysis thread on Twitter Placental abnormalities in #SarsCov19 infection were associated with significant higher incidence of unexplained stillbirths, and lower Apgar scores.
The placental pathology in #Covid19 infected mothers and its impact on pregnancy outcome…
#COVIDinpregnancy #CovidIsNotOver
