Opinion | Monica Bertagnolli: U.S. 'Ready' for Next Pandemic Threat
We see evidence of persistent live virus in humans in various tissue reservoirs, including surrounding nerves, the brain, the GI tract, to the lung.
Covid and the Immune System
Emmanuel on Twitter / X
SrsCov2 and T cells thread
Different roads, same destination: Study shows COVID variants evolve to suppress immunity
“We’ve figured out how this virus is going to behave as it goes forward, or at least a big part of it,” he said. “And what we need to do, just like we do with HIV, is fight it with a cocktail of therapies.”
Immune mechanisms underlying COVID-19 pathology and post-acute sequelae of SARS-CoV-2 infection (PASC)
A review of the complex immune system dysregulation in #LongCovid
John Hess MD on Twitter
Case Study update: Update. 8 weeks since this patient's mild COVID infection. CD4 down 21 to 276. CD4/CD8 ratio down to 0.8. No idea the frequency and duration of this in the general population. All I can say is this is not the only patient I've seen this in.
COVID-19: Study Suggests Long-term Damage to Immune System
"findings suggest that SARS-CoV-2 infection damages the CD8+ T cell response, an effect akin to that observed in earlier studies showing long-term damage to the immune system after infection with viruses such as hepatitis C or HIV."
Amy Mitchell on Twitter
Anecdote: "My absolute lymphocytes count is below 1 again. My lymphocytes subsets are as bad or worse as they were in 2020. Numbers had normalized in 2022 with Evusheld. So far as I know, I haven't been reinfected. It's not #HIV, but it's acquired immune deficiency. #LongCOVID #AIDS"
John Hess MD on Twitter
Case Study: I’ve got another, mid 60s. In hospital 3 times for FUO. Finally gets Dx coccidioidomycosis septicemia. COVID in February. Persistent lymphocytopenia since then. CD4/CD8 pending but pretty sure what it’s going to show. Worried how often this is going to happen.
John Hess MD on Twitter
Case Study: 62 healthy, HIV neg. COVID 3/28/23 fully vaccinated, mild symptoms which resolved within a week. Since then 2 cases of shingles, sinusitis and periorbital cellulitis. CD4 297. <200 is AIDS It's not every patient or every infection but it's more common than people want to believe
NIH study identifies features of Long COVID neurological symptoms
"people with Long COVID had lower levels of CD4+ and CD8+ T cells—immune cells involved in coordinating the immune system’s response to viruses—compared to healthy controls."
Accelerated T-Cell Immunosenescence in Cytomegalovirus-Seropositive Individuals After Severe Acute Respiratory Syndrome Coronavirus 2 Infection
Accelerated T-Cell Immunosenescence in Cytomegalovirus-Seropositive Individuals After Severe Acute Respiratory Syndrome Coronavirus 2 Infection
How the Coronavirus Short-Circuits the Immune System (Gift Article)
“In a disturbing parallel to HIV, the coronavirus can cause a depletion of important immune cells, recent studies found.”
Daniel Brittain Dugger on Twitter
Discussion related to Covid and Microglia: "Microglia enter the room."
Pnas
"Enhanced inhibition of MHC-I expression by SARS-CoV-2 Omicron subvariants"
I've had COVID and am constantly getting colds. Did COVID harm my immune system? Am I now at risk of other infectious diseases?
From Sept. 2022: "...what impacts has COVID had on your overall immune system?
It’s early days yet. But growing evidence suggests there are changes to your immune system that may put you at risk of other infectious diseases.
Here’s what we know so far:
Pnas
Omicron SARSCOV2 is NOT a textbook coronavirus as many thought, it clearly has T-cell immune evading capabilities! ➡️"Immune evasion from CD8 T cells could allow infected cells to survive better in the host. The virus could establish a safe niche for prolonged replication" #LongCovid ➡️Remarks: -Question now, is this cumulative with further Omicron subvariant reinfections?
- Some expert immunologists are tonight on the brink of developing a serious stomach ulcer, they were wrong! -Just comes to show that #SarsCoV2 is a totally new virus, outside any textbook😷
T. Ryan Gregory on Twitter
Detailed analysis thread of what we know so far about Covid and the immune system: You'd have to ignore a lot of research to say that SARS-CoV-2 infection has no effect on the immune system. So the scientific debate is about how severe, how often, for how long, how much more likely with repeated infections, and how it would manifest in different people.
laurie allee on Twitter
"The fact that they saw dramatically lower CD8 or killer T cell responses than everyone else indicated that there was some damage—something was happening after the infection in these people.”
Getting COVID-19 Could Weaken Your Immune System
"Even relatively easy bouts with COVID-19 can still take a toll on the immune system, according to a paper published Mar. 15 in the journal Immunity—particularly on T-cells, which provide long term and durable protection against viruses."
Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses — are we our own worst enemy?
"Analyses of patients have revealed marked dysregulation of the immune system in severe cases of human coronavirus infection, and there is ample evidence that aberrant immune responses to human coronaviruses are typified by impaired induction of..."
COVID left some with damaged immune response, study finds
"You have damage that, even in recovery from the infection, you haven't really recovered your ability to make those CD8+ cells. So something happened in the course of infection to prevent that, to damage your response,"
SARS-CoV-2 infection of thymus induces loss of function that correlates with disease severity
"Our data demonstrate that the human thymus is a target of SARS-CoV-2 and thymic function is altered following infection. These findings expand our current knowledge of the effects of SARS-CoV-2 infection on T-cell homeostasis..."
Longitudinal Analysis of COVID-19 Patients Shows Age-Associated T Cell Changes Independent of Ongoing Ill-Health
Longitudinal Analysis of COVID-19 Patients Shows Age-Associated T Cell Changes Independent of Ongoing Ill-Health
TONSILS ARE MAJOR SITES OF PROLONGED SARS-COV-2 INFECTION IN CHILDREN
TONSILS ARE MAJOR SITES OF PROLONGED SARS-COV-2 INFECTION IN CHILDREN
10815589221141841
COVID-19’s immuno-pathology and cardiovascular diseases
Tracking the clonal dynamics of SARS-CoV-2-specific T cells in children and adults with mild/asymptomatic COVID-19
NEW STUDY shows impaired generation of T cell memory responses in children vs adults. The rapid elimination of virus by the immune system reduces the antigen availability and prolonged cytokine exposure needed to generate long-lived cellular immunity.
Long COVID following mild SARS-CoV-2 infection: characteristic T cell alterations and response to antihistamines
Long COVID following mild SARS-CoV-2 infection: characteristic T cell alterations and response to antihistamines
Unexpected CD5+ B Cell Lymphocytosis during SARS-CoV-2 Infection: Relevance for the Pathophysiology of Chronic Lymphocytic Leukemia
Unexpected CD5+ B Cell Lymphocytosis during SARS-CoV-2 Infection:
SARS-CoV-2 escape from cytotoxic T cells during long-term COVID-19
SARS-CoV-2 escape from cytotoxic T cells during long-term COVID-19
SARS-CoV-2 infection of thymus induces loss of function that correlates with disease severity
ARS-CoV-2 infection of thymus induces loss of function that correlates with disease severity