Acquired Immune Deficiency Syndrome correlation with SARS-CoV-2 N genotypes
Covid and the Immune System
How (multiple) COVID infections impact your immune system
Researchers discover new cause of cytokine storm in COVID-19
“RAAS, a hormone system that normally turns on and off to help regulate blood pressure, body fluids and electrolytes, is the spark that pushes the immune response into overdrive.”
Research Reveals COVID-19's Body-Wide Impact
“Notably, we also found that activation of RAAS caused substantial damage to the lymph nodes, which hasn't been shown in COVID-19 before," said Beheshti, who is also director of McGowan's Center for Space Biomedicine . "This could explain the long-lasting immune dysregulation seen in survivors of COVID-19 and may contribute to long COVID."
It's also possible that damage to lymph nodes could impair the immune system's ability to detect and destroy cancerous cells, which could potentially help explain the post-pandemic increase in cancer cases.”
Notably, we also found that activation of RAAS caused substantial damage to the lymph nodes, which hasn't been shown in COVID-19 before," said Beheshti, who is also director of McGowan's Center for Space Biomedicine . "This could explain the long-lasting immune dysregulation seen in survivors of COVID-19 and may contribute to long COVID."It's also possible that damage to lymph nodes could impair the immune system's ability to detect and destroy cancerous cells, which could potentially help explain the post-pandemic increase in cancer cases.
COVID-19 progression and convalescence in common variable immunodeficiency patients show dysregulated adaptive immune responses and persistent type I interferon and inflammasome activation
“COVID-19 progression and convalescence in common variable immunodeficiency patients show dysregulated adaptive immune responses and persistent type I interferon and inflammasome activation.
…Our results show a broad dysregulation of both the innate and the adaptive immunity systems during SARS-CoV-2 infection and subsequent recovery in CVID patients, which gives us a unique insight into the effects of a viral challenge on the different immune cells”
The identification of a SARs-CoV2 S1 protein derived peptide with super-antigen-like stimulatory properties on T-cells
A peptide derived from the SARS-CoV-2 S1 spike protein, named P3, can stimulate a significant portion of human T cells.
This stimulation leads to increased production of inflammatory cytokines and granzyme B.
How the XEC Variant Pushes the Boundaries of Immune Evasion—and What It Means for Our Health
“The recently published study on the XEC variant (November 22, 2024) provides fresh insights into how this virus is evolving. (1) Combining this with the broader history of immune evasion, we see a troubling pattern: the virus continues to find ways to evade the immune system and in many cases, persist, potentially leaving lasting impacts on our health even for those who experience only mild or asymptomatic infections.”
COVID’S EFFECT ON THE IMMUNE SYSTEM
“This is an excellent series of graphics from @YaleSPH explaining what we do (and don’t) know about Covid’s effect on the immune system.
Much of this is informed by the work of Dr. Akiko Iwasaki (@VirusesImmunity).”
Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2
“Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2”
Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2
SARS-CoV-2 hijacks cholesterol trafficking to fuel infection and evade immune responses
SARS-CoV-2 hijacks cholesterol trafficking to fuel infection and evade immune responses
SARS-CoV-2 hijacks cholesterol trafficking to fuel infection and evade immune responses
Part 1 of 2
“Part 1 of 2 LaughterinLight PhD is a biomedical researcher, immunologist
- Answering: Can you explain the difference between how COVID affects your immune system vs how HIV affects it? * Feb 2024”
Chronic Viral Reactivation and Associated Host Immune Response and Clinical Outcomes in Acute COVID-19 and Post-Acute Sequelae of COVID-19
Study in the US followed 1,154 hospitalized COVID-19 patients for 12 months.
It found reactivation of latent viruses like EBV and CMV during acute COVID-19.
Persistent reactivation of certain viruses correlated with Long COVID symptoms.
This is what a yeast infection in your blood looks like under the microscope. I don't have to tell you how bad this is. As more & more people are repeatedly infected by SARS-CoV-2, wreaking havoc on their immune systems, we will see more & more of these type of infections. 🚫🦠😷
“This is what a yeast infection in your blood looks like under the microscope. I don't have to tell you how bad this is. As more & more people are repeatedly infected by SARS-CoV-2, wreaking havoc on their immune systems, we will see more & more of these type of infections.”
Looks like Yale school of public health has finally started to say what I have been repeatedly saying since 2020
“Looks like Yale school of public health has finally started to say what I have been repeatedly saying since 2020
1) covid creates longlasting autoimmunity by harming t regs 2) harms adaptive immunity 3) causes immune dysregulation 4) persists etc”
Frontiers | Cytokine Storm in COVID-19: The Current Evidence and Treatment Strategies
COVID-19 can cause a severe immune response known as a cytokine storm, leading to poor prognosis and potentially fatal outcomes.
The virus triggers excessive infiltration of immune cells, such as macrophages and T-helper 17 cells.
SARS-CoV-2 can trigger an overactive immune response, leading to the release of large amounts of pro-inflammatory cytokines.
“SARS-CoV-2 can trigger an overactive immune response, leading to the release of large amounts of pro-inflammatory cytokines.
This excessive cytokine release can cause widespread inflammation, leading to damage in various organs, including the lungs, heart, and kidneys.”
SARS-CoV-2 'steals' our proteins to protect itself from the immune system, study reveals
SARS-CoV-2 'steals' our proteins to protect itself from the immune system, study reveals
This is happening. Even in mild cases. My last infection in March my only symptoms were migraines. I had mild Covid and my CD8 T cells are hyper-activated and my CD4 are on the low end of normal
“This is happening. Even in mild cases. My last infection in March my only symptoms were migraines. I had mild Covid and my CD8 T cells are hyper-activated and my CD4 are on the low end of normal”
Severe COVID-19 may lead to long-term innate immune system changes
Severe COVID-19 can cause persistent alterations in the innate immune system, leading to high levels of inflammation even after recovery.
Changes in gene expression in blood-forming stem cells were found, which were passed down to immune cells.
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accelerated immunosenescence in CD4 and especially CD8 T-cell compartments may represent a common and unique outcome of SARS-CoV2 infection", not seen in the flu-like illnesses analysed in the same study
Rapid progression of CD8 and CD4 T cells to cellular exhaustion and senescence during SARS-CoV2 infection | Journal of Leukocyte Biology | Oxford Academic
COVID-19 rapidly increases senescent and exhausted T cells, particularly CD4 and CD8 T cells.
Both mild and severe COVID-19 cases showed increased markers of T-cell exhaustion and senescence with more pronounced changes in severe cases.
Getting COVID-19 Could Weaken Your Immune System
“Even relatively easy bouts with COVID-19 can still take a toll on the immune system, according to a paper published…in the journal Immunity—particularly on T-cells, which provide long term and durable protection against viruses.”
Even relatively easy bouts with COVID-19 can still take a toll on the immune system, according to a paper published Mar. 15 in the journal Immunity—particularly on T-cells, which provide long term and durable protection against viruses.
Immune Parallels: HIV/AIDS & Long COVID’s Lasting Impact
“Immune Parallels: HIV/AIDS & Long COVID’s Lasting Impact
HIV/AIDS & COVID-19, particularly long COVID, share several significant similarities, especially in terms of viral persistence, T cell damage, immune system dysfunction, & activation of other pathogens. These parallels are important for understanding the long-term effects of both infections and their impact on the immune system…” A thread:
Coronavirus Disease 2019 and Mycobacterium tuberculosis... : Journal of Preventive, Diagnostic and Treatment Strategies in Medicine
“the COVID-19 pandemic may lead to a spike in the incidence of active TB.”tuber
the COVID-19 pandemic may lead to a spike in the incidence of active TB.
Studies pinpoint immune cells and proteins linked to long COVID
“In the blood of the long COVID patients, the team [at the University of Alberta] found higher levels of various proteins related to systemic inflammation—especially galectin-9 and artemin.. higher levels of galectin-9 in patients are associated with increased inflammation and brain fog.. higher levels of artemin are associated with widespread pain, more severe pain and cognitive impairment.. galectin-9 is shed by stressed neutrophils—the most abundant white blood cells—in long COVID patients. This released galectin-9 can promote chronic inflammation by affecting various immune cells.. long COVID dysregulates the production of red blood cells, which results in an abundance of immature red blood cells in the blood of these patients. Normally, immature red blood cells are present in the bone marrow but not in the blood of healthy people. It is these immature red blood cells in the blood that suppress the immune system and contribute to the elevation of artemin in the plasma of long-COVID patients."
Thread by @Friesein on Thread Reader App
“COVID increases the risk of secondary infections by impairing mucosal clearance.”
COVID increases the risk of secondary infections by impairing mucosal clearance.
How Covid virus defeats body’s immune response - Yes Punjab News
Japanese researchers discovered that SARS-CoV-2, carries an enzyme that can act against a cell’s innate defence mechanism against viruses making it more infectious than previous SARS and MERS causing viruses.
This is the 5th year of the pandemic in the Let It Rip Kingdom of Sweden. Everyone is constantly reinfected with the immune damaging SARS-CoV-2.
“This is the 5th year of the pandemic in the Let It Rip Kingdom of Sweden. Everyone is constantly reinfected with the immune damaging SARS-CoV-2.
Respiratory virus/bacteria infections like Rhino/Enterovirus, Adenovirus, Mycoplasma pneumoniae or Pertussis are skyrocketing.
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An important paper!
“An important paper!
We keep focusing on Spike protein-only vaccines -> to our peril
It’s the 1 protein w the #1 MOST reasons to mutate!
Many parts of the virus also drive robust immune protection
Tmrws vaccines should focus on non-Spike to reduce variant immune evasion”
Missing immune cells may explain why COVID-19 vaccine protection quickly wanes
“Neither vaccinations nor immunity from infections seem to thwart SARS-CoV-2 for long. The frequency of new infections within a few months of a previous bout or a shot is one of COVID-19’s most vexing puzzles. Now, scientists have learned that a little-known type of immune cell in the bone marrow may play a major role in this failure.
The study, which appeared last month in Nature Medicine, found that people who received repeated doses of vaccine, and in some cases also became infected with SARS-CoV-2, largely failed to make special antibody-producing cells called long-lived plasma cells (LLPCs). “
Neither vaccinations nor immunity from infections seem to thwart SARS-CoV-2 for long. The frequency of new infections within a few months of a previous bout or a shot is one of COVID-19’s most vexing puzzles. Now, scientists have learned that a little-known type of immune cell in the bone marrow may play a major role in this failure.
The study, which appeared last month in Nature Medicine, found that people who received repeated doses of vaccine, and in some cases also became infected with SARS-CoV-2, largely failed to make special antibody-producing cells called long-lived plasma cells (LLPCs).