Covid and the Immune System

Covid and the Immune System

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Evasion of NKG2D-mediated cytotoxic immunity by sarbecoviruses
Evasion of NKG2D-mediated cytotoxic immunity by sarbecoviruses
A NEW study shows that cells infected with SARS-CoV-2 downregulate important immune signals known as NKG2D ligands. These ligands play a crucial role in activating the immune system, particularly natural killer (NK) cells, which are central to fighting viral infections.
·cell.com·
Evasion of NKG2D-mediated cytotoxic immunity by sarbecoviruses
John Hess MD on Twitter
John Hess MD on Twitter

Case Study update: Update. 8 weeks since this patient's mild COVID infection. CD4 down 21 to 276. CD4/CD8 ratio down to 0.8. No idea the frequency and duration of this in the general population. All I can say is this is not the only patient I've seen this in.

·twitter.com·
John Hess MD on Twitter
COVID-19: Study Suggests Long-term Damage to Immune System
COVID-19: Study Suggests Long-term Damage to Immune System
"findings suggest that SARS-CoV-2 infection damages the CD8+ T cell response, an effect akin to that observed in earlier studies showing long-term damage to the immune system after infection with viruses such as hepatitis C or HIV."
·infectioncontroltoday.com·
COVID-19: Study Suggests Long-term Damage to Immune System
Amy Mitchell on Twitter
Amy Mitchell on Twitter

Anecdote: "My absolute lymphocytes count is below 1 again. My lymphocytes subsets are as bad or worse as they were in 2020. Numbers had normalized in 2022 with Evusheld. So far as I know, I haven't been reinfected. It's not #HIV, but it's acquired immune deficiency. #LongCOVID #AIDS"

·twitter.com·
Amy Mitchell on Twitter
John Hess MD on Twitter
John Hess MD on Twitter

Case Study: I’ve got another, mid 60s. In hospital 3 times for FUO. Finally gets Dx coccidioidomycosis septicemia. COVID in February. Persistent lymphocytopenia since then. CD4/CD8 pending but pretty sure what it’s going to show. Worried how often this is going to happen.

·twitter.com·
John Hess MD on Twitter
John Hess MD on Twitter
John Hess MD on Twitter

Case Study: 62 healthy, HIV neg. COVID 3/28/23 fully vaccinated, mild symptoms which resolved within a week. Since then 2 cases of shingles, sinusitis and periorbital cellulitis. CD4 297. <200 is AIDS It's not every patient or every infection but it's more common than people want to believe

·twitter.com·
John Hess MD on Twitter
Accelerated T-Cell Immunosenescence in Cytomegalovirus-Seropositive Individuals After Severe Acute Respiratory Syndrome Coronavirus 2 Infection
Accelerated T-Cell Immunosenescence in Cytomegalovirus-Seropositive Individuals After Severe Acute Respiratory Syndrome Coronavirus 2 Infection
Accelerated T-Cell Immunosenescence in Cytomegalovirus-Seropositive Individuals After Severe Acute Respiratory Syndrome Coronavirus 2 Infection
·academic.oup.com·
Accelerated T-Cell Immunosenescence in Cytomegalovirus-Seropositive Individuals After Severe Acute Respiratory Syndrome Coronavirus 2 Infection
Pnas
Pnas
"Enhanced inhibition of MHC-I expression by SARS-CoV-2 Omicron subvariants"
·pnas.org·
Pnas
I've had COVID and am constantly getting colds. Did COVID harm my immune system? Am I now at risk of other infectious diseases?
I've had COVID and am constantly getting colds. Did COVID harm my immune system? Am I now at risk of other infectious diseases?

From Sept. 2022: "...what impacts has COVID had on your overall immune system?

It’s early days yet. But growing evidence suggests there are changes to your immune system that may put you at risk of other infectious diseases.

Here’s what we know so far:

·theconversation.com·
I've had COVID and am constantly getting colds. Did COVID harm my immune system? Am I now at risk of other infectious diseases?
Pnas
Pnas

Omicron SARSCOV2 is NOT a textbook coronavirus as many thought, it clearly has T-cell immune evading capabilities! ➡️"Immune evasion from CD8 T cells could allow infected cells to survive better in the host. The virus could establish a safe niche for prolonged replication" #LongCovid ➡️Remarks: -Question now, is this cumulative with further Omicron subvariant reinfections?

  • Some expert immunologists are tonight on the brink of developing a serious stomach ulcer, they were wrong! -Just comes to show that #SarsCoV2 is a totally new virus, outside any textbook😷
·pnas.org·
Pnas
T. Ryan Gregory on Twitter
T. Ryan Gregory on Twitter

Detailed analysis thread of what we know so far about Covid and the immune system: You'd have to ignore a lot of research to say that SARS-CoV-2 infection has no effect on the immune system. So the scientific debate is about how severe, how often, for how long, how much more likely with repeated infections, and how it would manifest in different people.

·twitter.com·
T. Ryan Gregory on Twitter
laurie allee on Twitter
laurie allee on Twitter
"The fact that they saw dramatically lower CD8 or killer T cell responses than everyone else indicated that there was some damage—something was happening after the infection in these people.”
·twitter.com·
laurie allee on Twitter
Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses — are we our own worst enemy?
Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses — are we our own worst enemy?
"Analyses of patients have revealed marked dysregulation of the immune system in severe cases of human coronavirus infection, and there is ample evidence that aberrant immune responses to human coronaviruses are typified by impaired induction of..."
·nature.com·
Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses — are we our own worst enemy?
Tracking the clonal dynamics of SARS-CoV-2-specific T cells in children and adults with mild/asymptomatic COVID-19
Tracking the clonal dynamics of SARS-CoV-2-specific T cells in children and adults with mild/asymptomatic COVID-19
NEW STUDY shows impaired generation of T cell memory responses in children vs adults. The rapid elimination of virus by the immune system reduces the antigen availability and prolonged cytokine exposure needed to generate long-lived cellular immunity.
·sciencedirect.com·
Tracking the clonal dynamics of SARS-CoV-2-specific T cells in children and adults with mild/asymptomatic COVID-19