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Prior human endemic coronavirus exposure does not affect humoral responses to SARS-CoV-2 protein vaccines
Prior human endemic coronavirus exposure does not affect humoral responses to SARS-CoV-2 protein vaccines
“We included measurement of pre-existing immunity to human endemic coronaviruses (HCoV) in a Phase I/II study of SARS-CoV-2 spike protein vaccine candidates. A Binding Antibody Multiplex Assay measured HCoV-specific IgG to the receptor binding domain or full-length spike of human coronaviruses HKU1, 229E, NL63, and OC43. We found no evidence for the impact of HCoV antibodies on neutralizing and binding antibody responses to the candidate SARS-CoV-2 vaccines.”
·flip.it·
Prior human endemic coronavirus exposure does not affect humoral responses to SARS-CoV-2 protein vaccines
Why Some People Are Naturally Immune to COVID-19 and Other Viruses - discoverwildscience
Why Some People Are Naturally Immune to COVID-19 and Other Viruses - discoverwildscience
“In the midst of the global pandemic, a curious phenomenon has emerged: some individuals seem to evade the grips of COVID-19 entirely, even when exposed. This mysterious resilience has sparked a wave of scientific curiosity and investigation. Could it be that some people are naturally immune to COVID-19 and other viruses? As we delve into this intriguing topic, we unravel the complex interplay of genetics, environment, and immune system dynamics that may hold the key to this enigma.”
·flip.it·
Why Some People Are Naturally Immune to COVID-19 and Other Viruses - discoverwildscience
emClinical & Translational Immunology/em | ASI Journal | Wiley Online Library
emClinical & Translational Immunology/em | ASI Journal | Wiley Online Library
“In conclusion, our findings demonstrate that immunomodulatory changes in both myeloid and lymphoid cells can persist for up to 17 months following COVID-19, even in individuals who experienced only MILD illness.”m
·onlinelibrary.wiley.com·
emClinical & Translational Immunology/em | ASI Journal | Wiley Online Library
Comprehensive molecular characterization of post-COVID condition: immunoglobulin suppression and persistent SARS-CoV-2 antigens as key pathophysiological drivers
Comprehensive molecular characterization of post-COVID condition: immunoglobulin suppression and persistent SARS-CoV-2 antigens as key pathophysiological drivers
Study analyzed blood from 65 Long COVID patients & found reduced immunoglobulin levels and persistent SARS‑CoV‑2 antigens (spike and nucleocapsid proteins). They used targeted mass spectrometry to measure SARS‑CoV‑2 spike & nucleocapsid proteins in plasma specifically
·sciencedirect.com·
Comprehensive molecular characterization of post-COVID condition: immunoglobulin suppression and persistent SARS-CoV-2 antigens as key pathophysiological drivers
Study says original COVID-19 vaccination did not stop immune system from fighting variants
Study says original COVID-19 vaccination did not stop immune system from fighting variants
“Prior COVID-19 vaccination did not stop the immune system from mounting a protective response to the Delta and Omicron strains, though new mutation-specific antibody production dipped slightly, according to a study led by researchers at the University of Arizona Health Sciences and published in Nature Immunology.”
·flip.it·
Study says original COVID-19 vaccination did not stop immune system from fighting variants
Research: COVID Virus Turns Fighters Into Suppressors
Research: COVID Virus Turns Fighters Into Suppressors
New research from Johns Hopkins finds that white blood cells may be altered by SARS2 to cease their normal function of destroying pathogens in the body and, instead, significantly inhibit other immune cells critical for fighting the virus
·miragenews.com·
Research: COVID Virus Turns Fighters Into Suppressors
Quarterly epidemiological commentary: mandatory Gram-negative bacteraemia, MRSA, MSSA and C. difficile infections (data up to October to December 2024)
Quarterly epidemiological commentary: mandatory Gram-negative bacteraemia, MRSA, MSSA and C. difficile infections (data up to October to December 2024)
Here's really strong evidence of immune damage from COVID among bacterial infections with no vaccines. Look at the sharp climbs in all since 2020.
·gov.uk·
Quarterly epidemiological commentary: mandatory Gram-negative bacteraemia, MRSA, MSSA and C. difficile infections (data up to October to December 2024)
SARS-CoV-2 induces neutrophil degranulation and differentiation into myeloid-derived suppressor cells associated with severe COVID-19
SARS-CoV-2 induces neutrophil degranulation and differentiation into myeloid-derived suppressor cells associated with severe COVID-19
A study new finds that neutrophils—the most abundant white blood cells in humans—may be altered by SARS-CoV-2 virus to cease their normal function of destroying pathogens in the body and, instead, significantly inhibit other immune cells critical for fighting the virus.
·science.org·
SARS-CoV-2 induces neutrophil degranulation and differentiation into myeloid-derived suppressor cells associated with severe COVID-19
(PDF) MCAS activated by Long COVID or PACS or by MIS-C and, MCAS activated by COVID Vaccines or by Post-Vaccination Syndrome (PVS): CRITERIA FOR CLINICAL DIAGNOSIS
(PDF) MCAS activated by Long COVID or PACS or by MIS-C and, MCAS activated by COVID Vaccines or by Post-Vaccination Syndrome (PVS): CRITERIA FOR CLINICAL DIAGNOSIS

Diagnostic Criteria for MCAS activated by LongCOVID & Post-Vaccination Syndrome PVS

·researchgate.net·
(PDF) MCAS activated by Long COVID or PACS or by MIS-C and, MCAS activated by COVID Vaccines or by Post-Vaccination Syndrome (PVS): CRITERIA FOR CLINICAL DIAGNOSIS
Spike proteins of coronaviruses activate mast cells for degranulation via stimulating Src/PI3K/AKT/Ca2+ intracellular signaling cascade | Journal of Virology
Spike proteins of coronaviruses activate mast cells for degranulation via stimulating Src/PI3K/AKT/Ca2+ intracellular signaling cascade | Journal of Virology

New study shows that SARS-CoV2 Spike Proteins induces Mast Cell Activation and MCAS

·journals.asm.org·
Spike proteins of coronaviruses activate mast cells for degranulation via stimulating Src/PI3K/AKT/Ca2+ intracellular signaling cascade | Journal of Virology
The Proof of Immune Harm Is In The Pudding
The Proof of Immune Harm Is In The Pudding
“Nevertheless, we know how covid harms the immune system to the extent to have predicted the immune harm, to the surprise of everyone who believed it was like the common cold or influenza.”
Nevertheless, we know how covid harms the immune system to the extent to have predicted the immune harm, to the surprise of everyone who believed it was like the common cold or influenza.
·easychair.info·
The Proof of Immune Harm Is In The Pudding
Is COVID quietly sabotaging our immune systems?
Is COVID quietly sabotaging our immune systems?
“Experts are increasingly coalescing around the view that COVID has weakened our immune systems, leaving us vulnerable to other infections”
Experts are increasingly coalescing around the view that COVID has weakened our immune systems, leaving us vulnerable to other infections
·canadianaffairs.news·
Is COVID quietly sabotaging our immune systems?
Rates of infection with other pathogens after a positive COVID-19 test versus a negative test in US veterans (November, 2021, to December, 2023): a retrospective cohort study
Rates of infection with other pathogens after a positive COVID-19 test versus a negative test in US veterans (November, 2021, to December, 2023): a retrospective cohort study

Covid and the immune system

A large-scale sample of Covid survivors and controls with a negative Covid test, showed Covid survivors were more prone to infections like bacterial infections and herpesviruses reactivation in the 12 month post Covid

·thelancet.com·
Rates of infection with other pathogens after a positive COVID-19 test versus a negative test in US veterans (November, 2021, to December, 2023): a retrospective cohort study
COVID-19 may put patients at risk for other infections for at least 1 year | CIDRAP
COVID-19 may put patients at risk for other infections for at least 1 year | CIDRAP
“a positive test for COVID-19 is associated with increased rates of diagnosis of various non–SARS-CoV-2 infections in the 12 months following an acute SARS-CoV-2 infection, even if the initial infection is mild to moderate.”
·cidrap.umn.edu·
COVID-19 may put patients at risk for other infections for at least 1 year | CIDRAP
Kids keep getting sicker as evidence for COVID immune damage builds
Kids keep getting sicker as evidence for COVID immune damage builds
“Through it all, governments and media grasped for any explanation that did not feature the collapse of public health and introduction of a novel virus that harms immune systems.”
·open.substack.com·
Kids keep getting sicker as evidence for COVID immune damage builds
In 2020 I claimed covid infections and reinfections would cause T cell exhaustion and harm to T cells Now, to my minimal surprise, the head of the american association of immunology has published the very hypothesis disparaged and called nonsense below; that covid harms the… https://t.co/NCx3OdDRh2 pic.twitter.com/4QC33RHiGE— AJ Leonardi, MBBS, PhD (@fitterhappierAJ) February 22, 2025
In 2020 I claimed covid infections and reinfections would cause T cell exhaustion and harm to T cells Now, to my minimal surprise, the head of the american association of immunology has published the very hypothesis disparaged and called nonsense below; that covid harms the… https://t.co/NCx3OdDRh2 pic.twitter.com/4QC33RHiGE— AJ Leonardi, MBBS, PhD (@fitterhappierAJ) February 22, 2025

“In 2020 I claimed covid infections and reinfections would cause T cell exhaustion and harm to T cells

Now, to my minimal surprise, the head of the american association of immunology has published the very hypothesis disparaged and called nonsense below; that covid harms the immune systems T cells and exhausts them.

I faced relentless attacks from many individuals. After two years of warning about immune harm and publishing opinions, my claim landed on the desk of Vincent Raccaniello, supposed “worlds virology professor” (a pretentious title) who dismissed it as Twitter nonsense in 2022

Vincent Rajkumar, the editor of blood, claimed it was nonsense.

Then Carlos Del Rio, the medical advisor to entities in the airline industry, said I could not even call myself an immunologist.

The abuse of me and my reputation continued.

Zeynep Tufekci, an editor at the new York times called me names and went as far as calling me crazy, saying “dolphins” whispered my opinions to me on covid’s immune harm.

She quotes, “Exhaustion? Not a thing.”

I faced utter disrespect and maliciousness.

“Someone” threatened a New York Times opinion editorial to the National Institutes of Health, where I was working at the time, claiming that I was a crank eroding trust in science for claiming covid harms the immune system. This is documented in emails.

They also went after Johns Hopkins. I was told I was no longer permitted to publish such opinions after the Dean was intimidated.

I hope they enjoy their reward. The reward is written testimony by their own hand of their wrongness to be displayed for all time on a matter of such great importance.

Their opinion wasn’t worthless, but rather it was the opposite of helpful. It was harmful. All their expertise only made the impact of an incorrect opinion greater.

I sacrificed career prospects and happiness. For some time, every Professor that wanted to downplay immunological harm from covid would virtue signal by attacking me. I say again, they say the T cells will save us, but who will save the t cells?”

·x.com·
In 2020 I claimed covid infections and reinfections would cause T cell exhaustion and harm to T cells Now, to my minimal surprise, the head of the american association of immunology has published the very hypothesis disparaged and called nonsense below; that covid harms the… https://t.co/NCx3OdDRh2 pic.twitter.com/4QC33RHiGE— AJ Leonardi, MBBS, PhD (@fitterhappierAJ) February 22, 2025
Immune damage in Long Covid
Immune damage in Long Covid
“Acute infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cause a respiratory illness that can be associated with systemic immune cell activation and inflammation, widespread multiorgan dysfunction, and thrombosis. Not everyone fully recovers from COVID-19, leading to Long Covid, the treatment of which is a major unmet clinical need”
Acute infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cause a respiratory illness that can be associated with systemic immune cell activation and inflammation, widespread multiorgan dysfunction, and thrombosis. Not everyone fully recovers from COVID-19, leading to Long Covid, the treatment of which is a major unmet clinical need
·science.org·
Immune damage in Long Covid