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Kids keep getting sicker as evidence for COVID immune damage builds
Kids keep getting sicker as evidence for COVID immune damage builds
“Through it all, governments and media grasped for any explanation that did not feature the collapse of public health and introduction of a novel virus that harms immune systems.”
·open.substack.com·
Kids keep getting sicker as evidence for COVID immune damage builds
In 2020 I claimed covid infections and reinfections would cause T cell exhaustion and harm to T cells Now, to my minimal surprise, the head of the american association of immunology has published the very hypothesis disparaged and called nonsense below; that covid harms the… https://t.co/NCx3OdDRh2 pic.twitter.com/4QC33RHiGE— AJ Leonardi, MBBS, PhD (@fitterhappierAJ) February 22, 2025
In 2020 I claimed covid infections and reinfections would cause T cell exhaustion and harm to T cells Now, to my minimal surprise, the head of the american association of immunology has published the very hypothesis disparaged and called nonsense below; that covid harms the… https://t.co/NCx3OdDRh2 pic.twitter.com/4QC33RHiGE— AJ Leonardi, MBBS, PhD (@fitterhappierAJ) February 22, 2025

“In 2020 I claimed covid infections and reinfections would cause T cell exhaustion and harm to T cells

Now, to my minimal surprise, the head of the american association of immunology has published the very hypothesis disparaged and called nonsense below; that covid harms the immune systems T cells and exhausts them.

I faced relentless attacks from many individuals. After two years of warning about immune harm and publishing opinions, my claim landed on the desk of Vincent Raccaniello, supposed “worlds virology professor” (a pretentious title) who dismissed it as Twitter nonsense in 2022

Vincent Rajkumar, the editor of blood, claimed it was nonsense.

Then Carlos Del Rio, the medical advisor to entities in the airline industry, said I could not even call myself an immunologist.

The abuse of me and my reputation continued.

Zeynep Tufekci, an editor at the new York times called me names and went as far as calling me crazy, saying “dolphins” whispered my opinions to me on covid’s immune harm.

She quotes, “Exhaustion? Not a thing.”

I faced utter disrespect and maliciousness.

“Someone” threatened a New York Times opinion editorial to the National Institutes of Health, where I was working at the time, claiming that I was a crank eroding trust in science for claiming covid harms the immune system. This is documented in emails.

They also went after Johns Hopkins. I was told I was no longer permitted to publish such opinions after the Dean was intimidated.

I hope they enjoy their reward. The reward is written testimony by their own hand of their wrongness to be displayed for all time on a matter of such great importance.

Their opinion wasn’t worthless, but rather it was the opposite of helpful. It was harmful. All their expertise only made the impact of an incorrect opinion greater.

I sacrificed career prospects and happiness. For some time, every Professor that wanted to downplay immunological harm from covid would virtue signal by attacking me. I say again, they say the T cells will save us, but who will save the t cells?”

·x.com·
In 2020 I claimed covid infections and reinfections would cause T cell exhaustion and harm to T cells Now, to my minimal surprise, the head of the american association of immunology has published the very hypothesis disparaged and called nonsense below; that covid harms the… https://t.co/NCx3OdDRh2 pic.twitter.com/4QC33RHiGE— AJ Leonardi, MBBS, PhD (@fitterhappierAJ) February 22, 2025
Immune damage in Long Covid
Immune damage in Long Covid
“Acute infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cause a respiratory illness that can be associated with systemic immune cell activation and inflammation, widespread multiorgan dysfunction, and thrombosis. Not everyone fully recovers from COVID-19, leading to Long Covid, the treatment of which is a major unmet clinical need”
Acute infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cause a respiratory illness that can be associated with systemic immune cell activation and inflammation, widespread multiorgan dysfunction, and thrombosis. Not everyone fully recovers from COVID-19, leading to Long Covid, the treatment of which is a major unmet clinical need
·science.org·
Immune damage in Long Covid
Doctors from Texas Warn That Post COVID-19 Individuals Are More Susceptible to Coccidioidomycosis Infections - Thailand Medical News
Doctors from Texas Warn That Post COVID-19 Individuals Are More Susceptible to Coccidioidomycosis Infections - Thailand Medical News
Doctors from Texas Warn That Post COVID-19 Individuals Are More Susceptible to Coccidioidomycosis Infections
·thailandmedical.news·
Doctors from Texas Warn That Post COVID-19 Individuals Are More Susceptible to Coccidioidomycosis Infections - Thailand Medical News
Immune dysregulation in long COVID patients uncovered in new study
Immune dysregulation in long COVID patients uncovered in new study
“The results showed that compared to COVID-19 patients who had fully recovered, long COVID patients showed evidence of immune dysregulation and systemic inflammation, with the distribution of T cells exhibiting global differences indicative of continued immune responses.”
The results showed that compared to COVID-19 patients who had fully recovered, long COVID patients showed evidence of immune dysregulation and systemic inflammation, with the distribution of T cells exhibiting global differences indicative of continued immune responses.
·news-medical.net·
Immune dysregulation in long COVID patients uncovered in new study
COVID-19 leads to long-term changes in the immune system, study shows
COVID-19 leads to long-term changes in the immune system, study shows

This is why there are so many pathogens repeatedly circulating in ways we didn’t see before Covid.

Immune systems can’t fight off the bugs because SarsCov2 damages the immune system.

“COVID-19 leads to considerable long-term changes in the immune system, even in mild cases. The findings could help to better understand the long-term consequences of an infection with SARS-CoV-2.”

COVID-19 leads to considerable long-term changes in the immune system, even in mild cases. The findings could help to better understand the long-term consequences of an infection with SARS-CoV-2.
·news-medical.net·
COVID-19 leads to long-term changes in the immune system, study shows
According to a NEW study, post COVID–19 patients showed immune dysregulation regardless of disease severity characterized mainly by altered expression of activation and functional markers in myeloid (CD39, CD64, CD85d, CD11b) and lymphoid cells (CD39, CD57, TIGIT). 1/
According to a NEW study, post COVID–19 patients showed immune dysregulation regardless of disease severity characterized mainly by altered expression of activation and functional markers in myeloid (CD39, CD64, CD85d, CD11b) and lymphoid cells (CD39, CD57, TIGIT). 1/
“According to a NEW study, post COVID–19 patients showed immune dysregulation regardless of disease severity characterized mainly by altered expression of activation and functional markers in myeloid (CD39, CD64, CD85d, CD11b) and lymphoid cells (CD39, CD57, TIGIT)”
·x.com·
According to a NEW study, post COVID–19 patients showed immune dysregulation regardless of disease severity characterized mainly by altered expression of activation and functional markers in myeloid (CD39, CD64, CD85d, CD11b) and lymphoid cells (CD39, CD57, TIGIT). 1/
In this first of the 2 part series of BBC Science in Action - 5 years of COVID, I discuss the importance of studying the immune responses to SARS-CoV-2 and mucosal vaccines with . With and others 👇🏼
In this first of the 2 part series of BBC Science in Action - 5 years of COVID, I discuss the importance of studying the immune responses to SARS-CoV-2 and mucosal vaccines with . With and others 👇🏼
“In this first of the 2 part series of BBC Science in Action - 5 years of COVID, I discuss the importance of studying the immune responses to SARS-CoV-2 and mucosal vaccines with @PeaseRoland. With @MarionKoopmans @c_drosten @dtsh2 and others 👇🏼”
·x.com·
In this first of the 2 part series of BBC Science in Action - 5 years of COVID, I discuss the importance of studying the immune responses to SARS-CoV-2 and mucosal vaccines with . With and others 👇🏼
Research Reveals COVID-19's Body-Wide Impact
Research Reveals COVID-19's Body-Wide Impact

“Notably, we also found that activation of RAAS caused substantial damage to the lymph nodes, which hasn't been shown in COVID-19 before," said Beheshti, who is also director of McGowan's Center for Space Biomedicine . "This could explain the long-lasting immune dysregulation seen in survivors of COVID-19 and may contribute to long COVID."

It's also possible that damage to lymph nodes could impair the immune system's ability to detect and destroy cancerous cells, which could potentially help explain the post-pandemic increase in cancer cases.”

Notably, we also found that activation of RAAS caused substantial damage to the lymph nodes, which hasn't been shown in COVID-19 before," said Beheshti, who is also director of McGowan's Center for Space Biomedicine . "This could explain the long-lasting immune dysregulation seen in survivors of COVID-19 and may contribute to long COVID."It's also possible that damage to lymph nodes could impair the immune system's ability to detect and destroy cancerous cells, which could potentially help explain the post-pandemic increase in cancer cases.
·miragenews.com·
Research Reveals COVID-19's Body-Wide Impact
COVID-19 progression and convalescence in common variable immunodeficiency patients show dysregulated adaptive immune responses and persistent type I interferon and inflammasome activation
COVID-19 progression and convalescence in common variable immunodeficiency patients show dysregulated adaptive immune responses and persistent type I interferon and inflammasome activation

“COVID-19 progression and convalescence in common variable immunodeficiency patients show dysregulated adaptive immune responses and persistent type I interferon and inflammasome activation.

…Our results show a broad dysregulation of both the innate and the adaptive immunity systems during SARS-CoV-2 infection and subsequent recovery in CVID patients, which gives us a unique insight into the effects of a viral challenge on the different immune cells”

·nature.com·
COVID-19 progression and convalescence in common variable immunodeficiency patients show dysregulated adaptive immune responses and persistent type I interferon and inflammasome activation
The identification of a SARs-CoV2 S1 protein derived peptide with super-antigen-like stimulatory properties on T-cells
The identification of a SARs-CoV2 S1 protein derived peptide with super-antigen-like stimulatory properties on T-cells

A peptide derived from the SARS-CoV-2 S1 spike protein, named P3, can stimulate a significant portion of human T cells.

This stimulation leads to increased production of inflammatory cytokines and granzyme B.

·biorxiv.org·
The identification of a SARs-CoV2 S1 protein derived peptide with super-antigen-like stimulatory properties on T-cells
How the XEC Variant Pushes the Boundaries of Immune Evasion—and What It Means for Our Health
How the XEC Variant Pushes the Boundaries of Immune Evasion—and What It Means for Our Health
“The recently published study on the XEC variant (November 22, 2024) provides fresh insights into how this virus is evolving. (1) Combining this with the broader history of immune evasion, we see a troubling pattern: the virus continues to find ways to evade the immune system and in many cases, persist, potentially leaving lasting impacts on our health even for those who experience only mild or asymptomatic infections.”
·open.substack.com·
How the XEC Variant Pushes the Boundaries of Immune Evasion—and What It Means for Our Health
Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2
Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2
“Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2”
Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2
·nature.com·
Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2