Spike proteins of coronaviruses activate mast cells for degranulation via stimulating Src/PI3K/AKT/Ca2+ intracellular signaling cascade | Journal of Virology
New study shows that SARS-CoV2 Spike Proteins induces Mast Cell Activation and MCAS
The identification of a SARs-CoV2 S1 protein derived peptide with super-antigen-like stimulatory properties on T-cells
A peptide derived from the SARS-CoV-2 S1 spike protein, named P3, can stimulate a significant portion of human T cells.
This stimulation leads to increased production of inflammatory cytokines and granzyme B.
An important paper!
“An important paper!
We keep focusing on Spike protein-only vaccines -> to our peril
It’s the 1 protein w the #1 MOST reasons to mutate!
Many parts of the virus also drive robust immune protection
Tmrws vaccines should focus on non-Spike to reduce variant immune evasion”