Glycan recognition by collectin-11 drives SARS-CoV-2 infectivity and membrane injury of respiratory epithelial cells
“These insights provide a strong rationale for CL-11 blockade to reduce SARS-CoV-2 infection and injury of the respiratory tract.”
The Kaposi’s Sarcoma Spike
Frontiers | Distinct characteristics of T cell receptor repertoire associated with the SARS-CoV-2 reinfection
New research shows SARS2 reinfection doesn’t “boost” your immunity - it narrows it. Each infection further imprints and restricts your T-cell diversity, making your immune response less adaptable over time.
In vitro complement activation via nucleocapsid and spike proteins of SARS-CoV-2 in COVID-19 patients
The N protein may play a larger role than spike in severe immune overreactions.
Thread by @AbudBakri on Thread Reader App
“You’re going to see a lot of immune failure and weird infections in young people over the next 5-10 years
It will start to pickup significantly in 2026”
You’re going to see a lot of immune failure and weird infections in young people over the next 5-10 years
It will start to pickup significantly in 2026
Postacute COVID-19 is Characterized by Gut Viral Antigen Persistence in Inflammatory Bowel Diseases
SARS-COV2 COVID at least temporarily causes lymphocytopenia (including T cells) immune suppression. The virus has been found to infect CD8 T cells. HIV AIDS is typically defined by CD4 T cell destruction. This study found COVID infected CD8 T cells.
Autoantibodies in long COVID: a systematic review
Plan for a world of post-COVID immune effects
“The average person’s immune system looks different than it did in 2019. We’re walking around with more inflammation, and with immune systems that don’t work quite as well as they did in the beforetimes”
Why scientists are rethinking the immune effects of SARS-CoV-2
Covid weakens your immune system. You are less likely to fight off pathogens and that is why you are “always sick”. '“There has definitely been a change in the character of the immune response since 2019,” says Tim Henrich, immunologist and senior author of the study. “It’s certainly impacting our immune health, and probably our overall health as well.”'
SARS-CoV-2 infection induces ZBP1-dependent PANoptosis in bystander cells | PNAS
SARS-CoV-2 and HIV-1: So Different yet so Alike. Immune Response at the Cellular and Molecular Level
SARS-CoV-2 and HIV-1 both cause CD4⁺ T cell loss, cytokine storms, and immune exhaustion.
Shared mechanisms—like pyroptosis and inhibitory receptor upregulation—suggest overlapping therapeutic targets.
Prior human endemic coronavirus exposure does not affect humoral responses to SARS-CoV-2 protein vaccines
“We included measurement of pre-existing immunity to human endemic coronaviruses (HCoV) in a Phase I/II study of SARS-CoV-2 spike protein vaccine candidates. A Binding Antibody Multiplex Assay measured HCoV-specific IgG to the receptor binding domain or full-length spike of human coronaviruses HKU1, 229E, NL63, and OC43. We found no evidence for the impact of HCoV antibodies on neutralizing and binding antibody responses to the candidate SARS-CoV-2 vaccines.”
Why Some People Are Naturally Immune to COVID-19 and Other Viruses - discoverwildscience
“In the midst of the global pandemic, a curious phenomenon has emerged: some individuals seem to evade the grips of COVID-19 entirely, even when exposed. This mysterious resilience has sparked a wave of scientific curiosity and investigation. Could it be that some people are naturally immune to COVID-19 and other viruses? As we delve into this intriguing topic, we unravel the complex interplay of genetics, environment, and immune system dynamics that may hold the key to this enigma.”
emClinical & Translational Immunology/em | ASI Journal | Wiley Online Library
“In conclusion, our findings demonstrate that immunomodulatory changes in both myeloid and lymphoid cells can persist for up to 17 months following COVID-19, even in individuals who experienced only MILD illness.”m
Transfer of SARS-CoV-2 nucleocapsid protein to uninfected epithelial cells induces antibody-mediated complement deposition
does covid damage your immune system
“COVID-19 disrupts immune system function, leading to both acute damage and long-term dysregulation.
The infection is associated with severe lymphopenia, particularly affecting T cells and natural killer cells, which can persist long after recovery.”
Thread by @drseanmullen on Thread Reader App
“I’ve been accused of being ‘hyperbolic’ for comparing Covid to AIDS. So let’s talk immune damage. With citations. 🧵”
Study says original COVID-19 vaccination did not stop immune system from fighting variants
“Prior COVID-19 vaccination did not stop the immune system from mounting a protective response to the Delta and Omicron strains, though new mutation-specific antibody production dipped slightly, according to a study led by researchers at the University of Arizona Health Sciences and published in Nature Immunology.”
Research: COVID Virus Turns Fighters Into Suppressors
New research from Johns Hopkins finds that white blood cells may be altered by SARS2 to cease their normal function of destroying pathogens in the body and, instead, significantly inhibit other immune cells critical for fighting the virus
Quarterly epidemiological commentary: mandatory Gram-negative bacteraemia, MRSA, MSSA and C. difficile infections (data up to October to December 2024)
Here's really strong evidence of immune damage from COVID among bacterial infections with no vaccines. Look at the sharp climbs in all since 2020.
COVID virus 'reprograms' infection fighters into immune system suppressors, study shows
“COVID virus 'reprograms' infection fighters into immune system suppressors, study shows”
COVID virus 'reprograms' infection fighters into immune system suppressors, study shows
SARS-CoV-2 induces neutrophil degranulation and differentiation into myeloid-derived suppressor cells associated with severe COVID-19
A study new finds that neutrophils—the most abundant white blood cells in humans—may be altered by SARS-CoV-2 virus to cease their normal function of destroying pathogens in the body and, instead, significantly inhibit other immune cells critical for fighting the virus.
Spike proteins of coronaviruses activate mast cells for degranulation via stimulating Src/PI3K/AKT/Ca2+ intracellular signaling cascade | Journal of Virology
New study shows that SARS-CoV2 Spike Proteins induces Mast Cell Activation and MCAS
The Proof of Immune Harm Is In The Pudding
“Nevertheless, we know how covid harms the immune system to the extent to have predicted the immune harm, to the surprise of everyone who believed it was like the common cold or influenza.”
Nevertheless, we know how covid harms the immune system to the extent to have predicted the immune harm, to the surprise of everyone who believed it was like the common cold or influenza.
The immunology of long COVID
Is COVID quietly sabotaging our immune systems?
“Experts are increasingly coalescing around the view that COVID has weakened our immune systems, leaving us vulnerable to other infections”
Experts are increasingly coalescing around the view that COVID has weakened our immune systems, leaving us vulnerable to other infections
Impact of antigenic evolution and original antigenic sin on SARS-CoV-2 immunity
TikTok · jaydo 🍉
How COVID dysregulates the immune system and affects blood vessels * CBC interview with Dr David Putrino of Mt Sinai Long COVID Clinic
Rates of infection with other pathogens after a positive COVID-19 test versus a negative test in US veterans (November, 2021, to December, 2023): a retrospective cohort study
Covid and the immune system
A large-scale sample of Covid survivors and controls with a negative Covid test, showed Covid survivors were more prone to infections like bacterial infections and herpesviruses reactivation in the 12 month post Covid
COVID-19 may put patients at risk for other infections for at least 1 year | CIDRAP
“a positive test for COVID-19 is associated with increased rates of diagnosis of various non–SARS-CoV-2 infections in the 12 months following an acute SARS-CoV-2 infection, even if the initial infection is mild to moderate.”