“In 2020 I claimed covid infections and reinfections would cause T cell exhaustion and harm to T cells
Now, to my minimal surprise, the head of the american association of immunology has published the very hypothesis disparaged and called nonsense below; that covid harms the immune systems T cells and exhausts them.
I faced relentless attacks from many individuals. After two years of warning about immune harm and publishing opinions, my claim landed on the desk of Vincent Raccaniello, supposed “worlds virology professor” (a pretentious title) who dismissed it as Twitter nonsense in 2022
Vincent Rajkumar, the editor of blood, claimed it was nonsense.
Then Carlos Del Rio, the medical advisor to entities in the airline industry, said I could not even call myself an immunologist.
The abuse of me and my reputation continued.
Zeynep Tufekci, an editor at the new York times called me names and went as far as calling me crazy, saying “dolphins” whispered my opinions to me on covid’s immune harm.
She quotes, “Exhaustion? Not a thing.”
I faced utter disrespect and maliciousness.
“Someone” threatened a New York Times opinion editorial to the National Institutes of Health, where I was working at the time, claiming that I was a crank eroding trust in science for claiming covid harms the immune system. This is documented in emails.
They also went after Johns Hopkins. I was told I was no longer permitted to publish such opinions after the Dean was intimidated.
I hope they enjoy their reward. The reward is written testimony by their own hand of their wrongness to be displayed for all time on a matter of such great importance.
Their opinion wasn’t worthless, but rather it was the opposite of helpful. It was harmful. All their expertise only made the impact of an incorrect opinion greater.
I sacrificed career prospects and happiness. For some time, every Professor that wanted to downplay immunological harm from covid would virtue signal by attacking me. I say again, they say the T cells will save us, but who will save the t cells?”
Here is a hypothesis that Covid harms NK cells
These cells kill circulating cancer cells and precancerous cells
NK dysfunction limit immune system control of precancer and cancer cells.
SARS-CoV-2 infects human CD4+ T helper cells by binding its spike glycoprotein to the CD4 molecule, impairing cell function and potentially causing cell death.
This mechanism involves the interaction of the virus with both CD4 and ACE2 receptors.
This is why there are so many pathogens repeatedly circulating in ways we didn’t see before Covid.
Immune systems can’t fight off the bugs because SarsCov2 damages the immune system.
“COVID-19 leads to considerable long-term changes in the immune system, even in mild cases. The findings could help to better understand the long-term consequences of an infection with SARS-CoV-2.”
Mucormycosis is a flesh eating fungus, nearly impossible to treat.
Virtually never seen in the immunocompetent........ Until 2022-Present
“Notably, we also found that activation of RAAS caused substantial damage to the lymph nodes, which hasn't been shown in COVID-19 before," said Beheshti, who is also director of McGowan's Center for Space Biomedicine . "This could explain the long-lasting immune dysregulation seen in survivors of COVID-19 and may contribute to long COVID."
It's also possible that damage to lymph nodes could impair the immune system's ability to detect and destroy cancerous cells, which could potentially help explain the post-pandemic increase in cancer cases.”
“COVID-19 progression and convalescence in common variable immunodeficiency patients show dysregulated adaptive immune responses and persistent type I interferon and inflammasome activation.
…Our results show a broad dysregulation of both the innate and the adaptive immunity systems during SARS-CoV-2 infection and subsequent recovery in CVID patients, which gives us a unique insight into the effects of a viral challenge on the different immune cells”
“This is an excellent series of graphics from @YaleSPH explaining what we do (and don’t) know about Covid’s effect on the immune system.
Much of this is informed by the work of Dr. Akiko Iwasaki (@VirusesImmunity).”
“Part 1 of 2 LaughterinLight PhD is a biomedical researcher, immunologist
- Answering: Can you explain the difference between how COVID affects your immune system vs how HIV affects it? * Feb 2024”
“Looks like Yale school of public health has finally started to say what I have been repeatedly saying since 2020
1) covid creates longlasting autoimmunity by harming t regs 2) harms adaptive immunity 3) causes immune dysregulation 4) persists etc”
COVID-19 can cause a severe immune response known as a cytokine storm, leading to poor prognosis and potentially fatal outcomes.
The virus triggers excessive infiltration of immune cells, such as macrophages and T-helper 17 cells.
“SARS-CoV-2 can trigger an overactive immune response, leading to the release of large amounts of pro-inflammatory cytokines.
This excessive cytokine release can cause widespread inflammation, leading to damage in various organs, including the lungs, heart, and kidneys.”
COVID-19 rapidly increases senescent and exhausted T cells, particularly CD4 and CD8 T cells.
Both mild and severe COVID-19 cases showed increased markers of T-cell exhaustion and senescence with more pronounced changes in severe cases.