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Immune dysregulation in long COVID patients uncovered in new study
Immune dysregulation in long COVID patients uncovered in new study
“The results showed that compared to COVID-19 patients who had fully recovered, long COVID patients showed evidence of immune dysregulation and systemic inflammation, with the distribution of T cells exhibiting global differences indicative of continued immune responses.”
The results showed that compared to COVID-19 patients who had fully recovered, long COVID patients showed evidence of immune dysregulation and systemic inflammation, with the distribution of T cells exhibiting global differences indicative of continued immune responses.
#Post-Acute Conditions#Immune system#T-cells#Immune dysregulation#Inflammation#Immune Deficiency
·news-medical.net·
Immune dysregulation in long COVID patients uncovered in new study
COVID-19 leads to long-term changes in the immune system, study shows
COVID-19 leads to long-term changes in the immune system, study shows

This is why there are so many pathogens repeatedly circulating in ways we didn’t see before Covid.

Immune systems can’t fight off the bugs because SarsCov2 damages the immune system.

“COVID-19 leads to considerable long-term changes in the immune system, even in mild cases. The findings could help to better understand the long-term consequences of an infection with SARS-CoV-2.”

COVID-19 leads to considerable long-term changes in the immune system, even in mild cases. The findings could help to better understand the long-term consequences of an infection with SARS-CoV-2.
#Immune system#Post-Acute Conditions#T-cells#Viral Persistence#Immune Deficiency#Immune dysregulation
·news-medical.net·
COVID-19 leads to long-term changes in the immune system, study shows
According to a NEW study, post COVID–19 patients showed immune dysregulation regardless of disease severity characterized mainly by altered expression of activation and functional markers in myeloid (CD39, CD64, CD85d, CD11b) and lymphoid cells (CD39, CD57, TIGIT). 1/
According to a NEW study, post COVID–19 patients showed immune dysregulation regardless of disease severity characterized mainly by altered expression of activation and functional markers in myeloid (CD39, CD64, CD85d, CD11b) and lymphoid cells (CD39, CD57, TIGIT). 1/
“According to a NEW study, post COVID–19 patients showed immune dysregulation regardless of disease severity characterized mainly by altered expression of activation and functional markers in myeloid (CD39, CD64, CD85d, CD11b) and lymphoid cells (CD39, CD57, TIGIT)”
#Immune system#Post-Acute Conditions#T-cells#Myeloid cells#Lymphoid cells#Immune dysregulation#Discussion#analysis
·x.com·
According to a NEW study, post COVID–19 patients showed immune dysregulation regardless of disease severity characterized mainly by altered expression of activation and functional markers in myeloid (CD39, CD64, CD85d, CD11b) and lymphoid cells (CD39, CD57, TIGIT). 1/
Research Reveals COVID-19's Body-Wide Impact
Research Reveals COVID-19's Body-Wide Impact

“Notably, we also found that activation of RAAS caused substantial damage to the lymph nodes, which hasn't been shown in COVID-19 before," said Beheshti, who is also director of McGowan's Center for Space Biomedicine . "This could explain the long-lasting immune dysregulation seen in survivors of COVID-19 and may contribute to long COVID."

It's also possible that damage to lymph nodes could impair the immune system's ability to detect and destroy cancerous cells, which could potentially help explain the post-pandemic increase in cancer cases.”

Notably, we also found that activation of RAAS caused substantial damage to the lymph nodes, which hasn't been shown in COVID-19 before," said Beheshti, who is also director of McGowan's Center for Space Biomedicine . "This could explain the long-lasting immune dysregulation seen in survivors of COVID-19 and may contribute to long COVID."It's also possible that damage to lymph nodes could impair the immune system's ability to detect and destroy cancerous cells, which could potentially help explain the post-pandemic increase in cancer cases.
#Long Covid#Post-Acute Conditions#Immune system#RAAS#Immune Deficiency#Immune dysregulation#cancer#lymph system dysfunction#organ damage
·miragenews.com·
Research Reveals COVID-19's Body-Wide Impact
Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2
Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2
“Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2”
Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2
#Immune system#Post-Acute Conditions#T-cells#inflammation#Immune Dysregulation#unccordinated adaptive immune response
·nature.com·
Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2
Chronic Viral Reactivation and Associated Host Immune Response and Clinical Outcomes in Acute COVID-19 and Post-Acute Sequelae of COVID-19
Chronic Viral Reactivation and Associated Host Immune Response and Clinical Outcomes in Acute COVID-19 and Post-Acute Sequelae of COVID-19

Study in the US followed 1,154 hospitalized COVID-19 patients for 12 months.

It found reactivation of latent viruses like EBV and CMV during acute COVID-19.

Persistent reactivation of certain viruses correlated with Long COVID symptoms.

#Immune system#reactivation of other viruses#EBV#CMV#opportunistic infections#Long Covid#Post-Acute Conditions
·biorxiv.org·
Chronic Viral Reactivation and Associated Host Immune Response and Clinical Outcomes in Acute COVID-19 and Post-Acute Sequelae of COVID-19
This is what a yeast infection in your blood looks like under the microscope. I don't have to tell you how bad this is. As more & more people are repeatedly infected by SARS-CoV-2, wreaking havoc on their immune systems, we will see more & more of these type of infections. 🚫🦠😷
This is what a yeast infection in your blood looks like under the microscope. I don't have to tell you how bad this is. As more & more people are repeatedly infected by SARS-CoV-2, wreaking havoc on their immune systems, we will see more & more of these type of infections. 🚫🦠😷
“This is what a yeast infection in your blood looks like under the microscope. I don't have to tell you how bad this is. As more & more people are repeatedly infected by SARS-CoV-2, wreaking havoc on their immune systems, we will see more & more of these type of infections.”
#Immune Deficiency#Immune Dysregulation#Immune system#David Christopher#Discussion#analysis#fungal infections#Post-Acute Conditions#inevitable effects of Forever Covid
·x.com·
This is what a yeast infection in your blood looks like under the microscope. I don't have to tell you how bad this is. As more & more people are repeatedly infected by SARS-CoV-2, wreaking havoc on their immune systems, we will see more & more of these type of infections. 🚫🦠😷
Looks like Yale school of public health has finally started to say what I have been repeatedly saying since 2020
Looks like Yale school of public health has finally started to say what I have been repeatedly saying since 2020

“Looks like Yale school of public health has finally started to say what I have been repeatedly saying since 2020

1) covid creates longlasting autoimmunity by harming t regs 2) harms adaptive immunity 3) causes immune dysregulation 4) persists etc”

#Long Covid#Post-Acute Conditions#Immune system#autoimmune#Viral Persistence#Immune Dysregulation#T-cell dysregulation#Adaptive Immunity#Immune Deficiency#Autoimmunity#AJ Leonardi#like minds
·x.com·
Looks like Yale school of public health has finally started to say what I have been repeatedly saying since 2020
SARS-CoV-2 can trigger an overactive immune response, leading to the release of large amounts of pro-inflammatory cytokines.
SARS-CoV-2 can trigger an overactive immune response, leading to the release of large amounts of pro-inflammatory cytokines.

“SARS-CoV-2 can trigger an overactive immune response, leading to the release of large amounts of pro-inflammatory cytokines.

This excessive cytokine release can cause widespread inflammation, leading to damage in various organs, including the lungs, heart, and kidneys.”

#immune dysregulation#Immune system#overactive immune response#Cytokines#Inflammation#organ damage#Post-Acute Conditions#acute Covid
·x.com·
SARS-CoV-2 can trigger an overactive immune response, leading to the release of large amounts of pro-inflammatory cytokines.
Rapid progression of CD8 and CD4 T cells to cellular exhaustion and senescence during SARS-CoV2 infection | Journal of Leukocyte Biology | Oxford Academic
Rapid progression of CD8 and CD4 T cells to cellular exhaustion and senescence during SARS-CoV2 infection | Journal of Leukocyte Biology | Oxford Academic

COVID-19 rapidly increases senescent and exhausted T cells, particularly CD4 and CD8 T cells.

Both mild and severe COVID-19 cases showed increased markers of T-cell exhaustion and senescence with more pronounced changes in severe cases.

#Immune system#T-cells#Post-Acute Conditions#immune dysregulation
·academic.oup.com·
Rapid progression of CD8 and CD4 T cells to cellular exhaustion and senescence during SARS-CoV2 infection | Journal of Leukocyte Biology | Oxford Academic
Getting COVID-19 Could Weaken Your Immune System
Getting COVID-19 Could Weaken Your Immune System
“Even relatively easy bouts with COVID-19 can still take a toll on the immune system, according to a paper published…in the journal Immunity—particularly on T-cells, which provide long term and durable protection against viruses.”
Even relatively easy bouts with COVID-19 can still take a toll on the immune system, according to a paper published Mar. 15 in the journal Immunity—particularly on T-cells, which provide long term and durable protection against viruses.
#Immune system#Long Covid#Post-Acute Conditions#T-cells
·time.com·
Getting COVID-19 Could Weaken Your Immune System
Immune Parallels: HIV/AIDS & Long COVID’s Lasting Impact
Immune Parallels: HIV/AIDS & Long COVID’s Lasting Impact

“Immune Parallels: HIV/AIDS & Long COVID’s Lasting Impact

HIV/AIDS & COVID-19, particularly long COVID, share several significant similarities, especially in terms of viral persistence, T cell damage, immune system dysfunction, & activation of other pathogens. These parallels are important for understanding the long-term effects of both infections and their impact on the immune system…” A thread:

#Immune system#Long Covid#Post-Acute Conditions#T-cells#Viral Persistence#HIV/AIDS#coV-AIDS#Discussion#analysis
·x.com·
Immune Parallels: HIV/AIDS & Long COVID’s Lasting Impact
Studies pinpoint immune cells and proteins linked to long COVID
Studies pinpoint immune cells and proteins linked to long COVID

“In the blood of the long COVID patients, the team [at the University of Alberta] found higher levels of various proteins related to systemic inflammation—especially galectin-9 and artemin.. higher levels of galectin-9 in patients are associated with increased inflammation and brain fog.. higher levels of artemin are associated with widespread pain, more severe pain and cognitive impairment.. galectin-9 is shed by stressed neutrophils—the most abundant white blood cells—in long COVID patients. This released galectin-9 can promote chronic inflammation by affecting various immune cells.. long COVID dysregulates the production of red blood cells, which results in an abundance of immature red blood cells in the blood of these patients. Normally, immature red blood cells are present in the bone marrow but not in the blood of healthy people. It is these immature red blood cells in the blood that suppress the immune system and contribute to the elevation of artemin in the plasma of long-COVID patients."

#Post-Acute Conditions#immune dysregulation#Inflammation#blood cell#artemin#galectin-9#Immune system#proteins#markers#Long Covid
·medicalxpress.com·
Studies pinpoint immune cells and proteins linked to long COVID
Over but not gone: lingering epigenetic effects of COVID-19
Over but not gone: lingering epigenetic effects of COVID-19

“Long COVID’ affects nearly one in five adults who have had coronavirus disease 2019 (COVID-19), yet the mechanisms underlying this disorder remain poorly understood. In a new study, Cheong et al. show that the epigenetic and transcriptional state of myeloid immune cells and their progenitors are durably altered in patients following severe COVID-19.”

#Immune system#immune dysregulation#T cells#Long Covid#autoimmune#autoimmunity#PASC#Post-Acute Conditions
·sciencedirect.com·
Over but not gone: lingering epigenetic effects of COVID-19
SARS-CoV-2 infection and persistence in the human body and brain at autopsy
SARS-CoV-2 infection and persistence in the human body and brain at autopsy
"We... conclusively demonstrate that SARS-CoV-2 is capable of infecting and replicating within [the heart, lymph nodes, small intestine, adrenal glands] and many other tissues, including brain... as late as 230 days following symptom onset..."
#organ damage#Immune system#Viral Persistence#Mortality#long covid#Post-Acute Conditions
·nature.com·
SARS-CoV-2 infection and persistence in the human body and brain at autopsy