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According to a NEW study, post COVID–19 patients showed immune dysregulation regardless of disease severity characterized mainly by altered expression of activation and functional markers in myeloid (CD39, CD64, CD85d, CD11b) and lymphoid cells (CD39, CD57, TIGIT). 1/
According to a NEW study, post COVID–19 patients showed immune dysregulation regardless of disease severity characterized mainly by altered expression of activation and functional markers in myeloid (CD39, CD64, CD85d, CD11b) and lymphoid cells (CD39, CD57, TIGIT). 1/
“According to a NEW study, post COVID–19 patients showed immune dysregulation regardless of disease severity characterized mainly by altered expression of activation and functional markers in myeloid (CD39, CD64, CD85d, CD11b) and lymphoid cells (CD39, CD57, TIGIT)”
#Immune system#Post-Acute Conditions#T-cells#Myeloid cells#Lymphoid cells#Immune dysregulation#Discussion#analysis
·x.com·
According to a NEW study, post COVID–19 patients showed immune dysregulation regardless of disease severity characterized mainly by altered expression of activation and functional markers in myeloid (CD39, CD64, CD85d, CD11b) and lymphoid cells (CD39, CD57, TIGIT). 1/
The identification of a SARs-CoV2 S1 protein derived peptide with super-antigen-like stimulatory properties on T-cells
The identification of a SARs-CoV2 S1 protein derived peptide with super-antigen-like stimulatory properties on T-cells

A peptide derived from the SARS-CoV-2 S1 spike protein, named P3, can stimulate a significant portion of human T cells.

This stimulation leads to increased production of inflammatory cytokines and granzyme B.

#Immune system#T-cells#Superantigens#S1 protein#Cytokines#inflammation#spike protein
·biorxiv.org·
The identification of a SARs-CoV2 S1 protein derived peptide with super-antigen-like stimulatory properties on T-cells
Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2
Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2
“Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2”
Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2
#Immune system#Post-Acute Conditions#T-cells#inflammation#Immune Dysregulation#unccordinated adaptive immune response
·nature.com·
Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2
Rapid progression of CD8 and CD4 T cells to cellular exhaustion and senescence during SARS-CoV2 infection | Journal of Leukocyte Biology | Oxford Academic
Rapid progression of CD8 and CD4 T cells to cellular exhaustion and senescence during SARS-CoV2 infection | Journal of Leukocyte Biology | Oxford Academic

COVID-19 rapidly increases senescent and exhausted T cells, particularly CD4 and CD8 T cells.

Both mild and severe COVID-19 cases showed increased markers of T-cell exhaustion and senescence with more pronounced changes in severe cases.

#Immune system#T-cells#Post-Acute Conditions#immune dysregulation
·academic.oup.com·
Rapid progression of CD8 and CD4 T cells to cellular exhaustion and senescence during SARS-CoV2 infection | Journal of Leukocyte Biology | Oxford Academic
Getting COVID-19 Could Weaken Your Immune System
Getting COVID-19 Could Weaken Your Immune System
“Even relatively easy bouts with COVID-19 can still take a toll on the immune system, according to a paper published…in the journal Immunity—particularly on T-cells, which provide long term and durable protection against viruses.”
Even relatively easy bouts with COVID-19 can still take a toll on the immune system, according to a paper published Mar. 15 in the journal Immunity—particularly on T-cells, which provide long term and durable protection against viruses.
#Immune system#Long Covid#Post-Acute Conditions#T-cells
·time.com·
Getting COVID-19 Could Weaken Your Immune System
Immune Parallels: HIV/AIDS & Long COVID’s Lasting Impact
Immune Parallels: HIV/AIDS & Long COVID’s Lasting Impact

“Immune Parallels: HIV/AIDS & Long COVID’s Lasting Impact

HIV/AIDS & COVID-19, particularly long COVID, share several significant similarities, especially in terms of viral persistence, T cell damage, immune system dysfunction, & activation of other pathogens. These parallels are important for understanding the long-term effects of both infections and their impact on the immune system…” A thread:

#Immune system#Long Covid#Post-Acute Conditions#T-cells#Viral Persistence#HIV/AIDS#coV-AIDS#Discussion#analysis
·x.com·
Immune Parallels: HIV/AIDS & Long COVID’s Lasting Impact
I’m sure everyone has seen it by now, but I suspect there is a lot of confusion about the paper and the information presented. This thread hopefully clears things up a bit.
I’m sure everyone has seen it by now, but I suspect there is a lot of confusion about the paper and the information presented. This thread hopefully clears things up a bit.

Excellent explanation of mechanism discussed in recent SarsCov2 causing AIDS paper.

“So, to recap: Researchers identified two genotypes of the SARS-CoV-2 nucleocapsid protein that are able to use CD147 on host lymphocytes to infect those cells, and explain how that could contribute to immune deficiency and viral persistence (by citing independent research).”

#AIDS#lymphopenia#T-cells#Immune system
·x.com·
I’m sure everyone has seen it by now, but I suspect there is a lot of confusion about the paper and the information presented. This thread hopefully clears things up a bit.
John Hess MD on Twitter
John Hess MD on Twitter

Case Study update: Update. 8 weeks since this patient's mild COVID infection. CD4 down 21 to 276. CD4/CD8 ratio down to 0.8. No idea the frequency and duration of this in the general population. All I can say is this is not the only patient I've seen this in.

#Immune system#T-cells
·twitter.com·
John Hess MD on Twitter
COVID-19: Study Suggests Long-term Damage to Immune System
COVID-19: Study Suggests Long-term Damage to Immune System
"findings suggest that SARS-CoV-2 infection damages the CD8+ T cell response, an effect akin to that observed in earlier studies showing long-term damage to the immune system after infection with viruses such as hepatitis C or HIV."
#Immune system#T-cells
·infectioncontroltoday.com·
COVID-19: Study Suggests Long-term Damage to Immune System
John Hess MD on Twitter
John Hess MD on Twitter

Case Study: 62 healthy, HIV neg. COVID 3/28/23 fully vaccinated, mild symptoms which resolved within a week. Since then 2 cases of shingles, sinusitis and periorbital cellulitis. CD4 297. <200 is AIDS It's not every patient or every infection but it's more common than people want to believe

#Immune system#opportunistic infections#T-cells
·twitter.com·
John Hess MD on Twitter
Accelerated T-Cell Immunosenescence in Cytomegalovirus-Seropositive Individuals After Severe Acute Respiratory Syndrome Coronavirus 2 Infection
Accelerated T-Cell Immunosenescence in Cytomegalovirus-Seropositive Individuals After Severe Acute Respiratory Syndrome Coronavirus 2 Infection
Accelerated T-Cell Immunosenescence in Cytomegalovirus-Seropositive Individuals After Severe Acute Respiratory Syndrome Coronavirus 2 Infection
#T-cells#opportunistic infections#Immune system
·academic.oup.com·
Accelerated T-Cell Immunosenescence in Cytomegalovirus-Seropositive Individuals After Severe Acute Respiratory Syndrome Coronavirus 2 Infection
Pnas
Pnas

Omicron SARSCOV2 is NOT a textbook coronavirus as many thought, it clearly has T-cell immune evading capabilities! ➡️"Immune evasion from CD8 T cells could allow infected cells to survive better in the host. The virus could establish a safe niche for prolonged replication" #LongCovid ➡️Remarks: -Question now, is this cumulative with further Omicron subvariant reinfections?

  • Some expert immunologists are tonight on the brink of developing a serious stomach ulcer, they were wrong! -Just comes to show that #SarsCoV2 is a totally new virus, outside any textbook😷
#Immune system#T-cells
·pnas.org·
Pnas
laurie allee on Twitter
laurie allee on Twitter
"The fact that they saw dramatically lower CD8 or killer T cell responses than everyone else indicated that there was some damage—something was happening after the infection in these people.”
#Immune system#T-cells#reinfection
·twitter.com·
laurie allee on Twitter
Tracking the clonal dynamics of SARS-CoV-2-specific T cells in children and adults with mild/asymptomatic COVID-19
Tracking the clonal dynamics of SARS-CoV-2-specific T cells in children and adults with mild/asymptomatic COVID-19
NEW STUDY shows impaired generation of T cell memory responses in children vs adults. The rapid elimination of virus by the immune system reduces the antigen availability and prolonged cytokine exposure needed to generate long-lived cellular immunity.
#Kids#Immune system#T-cells
·sciencedirect.com·
Tracking the clonal dynamics of SARS-CoV-2-specific T cells in children and adults with mild/asymptomatic COVID-19