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Prior human endemic coronavirus exposure does not affect humoral responses to SARS-CoV-2 protein vaccines
Prior human endemic coronavirus exposure does not affect humoral responses to SARS-CoV-2 protein vaccines
“We included measurement of pre-existing immunity to human endemic coronaviruses (HCoV) in a Phase I/II study of SARS-CoV-2 spike protein vaccine candidates. A Binding Antibody Multiplex Assay measured HCoV-specific IgG to the receptor binding domain or full-length spike of human coronaviruses HKU1, 229E, NL63, and OC43. We found no evidence for the impact of HCoV antibodies on neutralizing and binding antibody responses to the candidate SARS-CoV-2 vaccines.”
#Immune system#antibodies#vaccine#antigenic imprinting#immune system
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Prior human endemic coronavirus exposure does not affect humoral responses to SARS-CoV-2 protein vaccines
Study says original COVID-19 vaccination did not stop immune system from fighting variants
Study says original COVID-19 vaccination did not stop immune system from fighting variants
“Prior COVID-19 vaccination did not stop the immune system from mounting a protective response to the Delta and Omicron strains, though new mutation-specific antibody production dipped slightly, according to a study led by researchers at the University of Arizona Health Sciences and published in Nature Immunology.”
#Immune system#vaccine#antibodies#variants#Delta#Omicron#protective response#mutation-specific antibody
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Study says original COVID-19 vaccination did not stop immune system from fighting variants
Long lived antibodies can be made in the bone marrow, the holy grail of vaccination. This is what happens after different time intervals after flu, tetanus and mRNA Covid vaccines. The box in purple is SARS-CoV-2 in the bone marrow. At months 2.5 and 14 they are empty.🧵
Long lived antibodies can be made in the bone marrow, the holy grail of vaccination. This is what happens after different time intervals after flu, tetanus and mRNA Covid vaccines. The box in purple is SARS-CoV-2 in the bone marrow. At months 2.5 and 14 they are empty.🧵
“SARS-CoV-2-specific plasma cells are not durably established in the bone marrow long-lived compartment after mRNA vaccination”
#vaccine#reinfection#Covid Statistics#Discussion#analysis#Immune system
·x.com·
Long lived antibodies can be made in the bone marrow, the holy grail of vaccination. This is what happens after different time intervals after flu, tetanus and mRNA Covid vaccines. The box in purple is SARS-CoV-2 in the bone marrow. At months 2.5 and 14 they are empty.🧵